The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
CD11b+Ly6G−myeloid cells mediate mechanical inflammatory pain hypersensitivity
Open accessAbstract
Significance: Inflammatory mediators can activate and sensitize nociceptors, specialized high-threshold nerve fibers that relay noxious signals to the spinal cord and brain to initiate pain. However, the contribution of specific immune cell types to pain in animal models of inflammation remains largely unknown. We therefore characterized the immune response in two widely used preclinical models of inflammatory pain: intraplantar injection of complete Freund’s adjuvant and plantar incisional wound. Cell-depletion strategies investigated the contribution of neutrophils, myeloid cells (including monocytes and macrophages), and T cells to pain behavior outcomes. Our results show that these two models induced quite different inflammatory processes and that targeted elimination of a subpopulation of nonneutrophil myeloid cells blocked development of mechanical hypersensitivity following incisional wounds.
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Cites
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649
Yang, J., Zhang, L., Yu, C., Yang, X.-F., & Wang, H. (2014) · Biomarker Research · doi:10.1186/2050-7771-2-1 · Cited by 1,099
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Willenborg, S., Lucas, T., van Loo, G., Knipper, J. A., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A., Ferrara, N., et al. (2012) · Blood · doi:10.1182/blood-2012-01-403386 · Cited by 534 · cited 1×
“Nonneutrophil myeloid cells are primarily responsible for the phagocytosis of debris and invading pathogens in incisional wounds, and, although they are not required for tissue repair, they do play important roles in vascularization, fibrosis, and scarring (37, 68, 69).”
BackgroundAccelerated wound closure in neutrophil-depleted mice
Dovi, J. V., He, L.-K., & DiPietro, L. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802406 · Cited by 525
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
Kim, J. V., Kang, S. S., Dustin, M. L., & McGavern, D. B. (2009) · Nature · doi:10.1038/nature07591 · Cited by 326
Cited by
Pain regulation by non-neuronal cells and inflammation
Ji, R.-R., Chamessian, A., & Zhang, Y.-Q. (2016) · Science · doi:10.1126/science.aaf8924 · Cited by 1,314
The microbiome and host behavior
Vuong, H. E., Yano, J. M., Fung, T. C., & Hsiao, E. Y. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031347 · Cited by 537
Putative roles of SLC7A5 (LAT1) transporter in pain
Alles, S. R. A., Gomez, K., Moutal, A., & Khanna, R. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100050 · Cited by 16
Metadata
- Authors
- Ghasemlou, N., Chiu, I. M., Julien, J.-P., & Woolf, C. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-11-23
- Volume
- 112
- Issue
- 49
- Pages
- E6808-17
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2177933255
- Cited by
- 188
- References
- 9
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ghasemlou, N., Chiu, I. M., Julien, J.-P., & Woolf, C. J. (2015). CD11b+Ly6G−myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1501372112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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