The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
Open accessAbstract
Barrier-to-autointegration factor (BAF) is a highly conserved cellular protein that was identified by its activity in protecting retroviral DNA against autointegration. We show that BAF has the property of bridging double-stranded DNA in a highly ordered nucleoprotein complex. Whereas BAF protein alone is a dimer in solution, upon binding DNA, BAF forms a dodecamer with DNA bound at multiple discrete sites in the complex. The interactions between BAF and DNA are entirely nonspecific with respect to DNA sequence. The dual interaction of BAF with DNA and LAP2, a protein associated with the nuclear lamina, suggests a role for LAP2 in chromosome organization. Consistent with this idea, RNA interference experiments with Caenorhabditis elegans reveal a defect in mitosis.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
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Caenorhabditis elegans : modern biological analysis of an organism
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PERKINS, S. J. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09653.x · Cited by 582
TARGET SITE SELECTION IN TRANSPOSITION
Craig, N. L. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.437 · Cited by 290
A previously unidentified host protein protects retroviral DNA from autointegration
Lee, M. S., & Craigie, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1528 · Cited by 281
Self-citationLAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction
Furukawa, K. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.15.2485 · Cited by 232
The nuclear envelope, muscular dystrophy and gene expression
Wilson, K. L. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01708-0 · Cited by 222
The barrier-to-autointegration protein is a host factor for HIV type 1 integration
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Cited by
Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940
The nuclear lamina comes of age
Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K., & Wilson, K. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1550 · Cited by 834
Nuclear Lamins: Laminopathies and Their Role in Premature Ageing
Broers, J. L. V., Ramaekers, F. C. S., Bonne, G., Yaou, R. B., & Hutchison, C. J. (2006) · Physiological Reviews · doi:10.1152/physrev.00047.2005 · Cited by 578
Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
Sridharan, S., Kurzawa, N., Werner, T., Günthner, I., Helm, D., Huber, W., Bantscheff, M., & Savitski, M. M. (2019) · Nature Communications · doi:10.1038/s41467-019-09107-y · Cited by 267
Host factors exploited by retroviruses
Goff, S. P. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1541 · Cited by 247
Metadata
- Authors
- Zheng, R., Ghirlando, R., Lee, M. S., Mizuuchi, K., Krause, M., & Craigie, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-07-25
- Volume
- 97
- Issue
- 16
- Pages
- 8997-9002
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2025286269
- Cited by
- 274
- References
- 17
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, R., Ghirlando, R., Lee, M. S., Mizuuchi, K., Krause, M., & Craigie, R. (2000). Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.150240197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
