The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Periodic retinoic acid–STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis
Open accessAbstract
Significance: As male sex cells mature into sperm, two pivotal transitions are spermatogonial differentiation (exit from the stem cell pool) and meiotic initiation. These transitions occur in physical proximity, with 8.6-d periodicity. We report that the gene Stra8 , essential for meiotic initiation, also promotes (but is not required for) spermatogonial differentiation. Moreover, injected RA induces both transitions to occur precociously. We conclude that a periodic RA signal, acting instructively through the common target Stra8 , coordinates these transitions. This RA signal intersects with two distinct windows of sex-cell competency, which both begin while RA levels are low; sex cells respond quickly to rising RA. These mechanisms help account for the elaborate organization of sperm production, and its prodigious output.
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Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
limma: Linear Models for Microarray Data
Smyth, G. K. (2005) · Statistics for Biology and Health · doi:10.1007/0-387-29362-0_23 · Cited by 5,796
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
Cited by
Spermatogenesis: The Commitment to Meiosis
Griswold, M. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00013.2015 · Cited by 825
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq
Green, C. D., Ma, Q., Manske, G. L., Shami, A. N., Zheng, X., Marini, S., Moritz, L., Sultan, C., Gurczynski, S. J., Moore, B. B., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.025 · Cited by 521
The nature and dynamics of spermatogonial stem cells
de Rooij, D. G. (2017) · Development · doi:10.1242/dev.146571 · Cited by 313
Self-citationEffects of Growth Factors on In Vitro Culture of Neonatal Piglet Testicular Tissue Fragments
Ibtisham, F., Cham, T.-C., Fayaz, M. A., & Honaramooz, A. (2023) · Cells · doi:10.3390/cells12182234 · Cited by 12
Metadata
- Authors
- Endo, T., Romer, K. A., Anderson, E. L., Baltus, A. E., de Rooij, D. G., & Page, D. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-04-20
- Volume
- 112
- Issue
- 18
- Pages
- E2347-56
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2091028885
- Cited by
- 230
- References
- 3
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Endo, T., Romer, K. A., Anderson, E. L., Baltus, A. E., de Rooij, D. G., & Page, D. C. (2015). Periodic retinoic acid–STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1505683112
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