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Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes
Open accessAbstract
Significance: Fetal extravillous trophoblasts (EVT) invade uterine tissue and interact with maternal immune cells during pregnancy. EVT express human leukocyte antigen-C (HLA-C) and -G (HLA-G). Although polymorphic HLA-C can elicit a maternal immune response, HLA-G has been associated with induction of immune tolerance. We have succeeded in isolating all maternal immune cell types as well as EVT from human placental tissue. These methods were used to elucidate the unique charateristics of EVT as well as their interaction with maternal immune cells. We demonstrate that EVT are specialized cells whose properties are not imitated by HLA‐G–expressing surrogate cell lines. Studies using primary EVT are crucial for understanding maternal–fetal tolerance and development of pregnancy complications such as preeclampsia and miscarriages.
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Cited by
The unique immunological and microbial aspects of pregnancy
Mor, G., Aldo, P., & Alvero, A. B. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.64 · Cited by 1,041
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Self-citationRegulatory T cells in embryo implantation and the immune response to pregnancy
Robertson, S. A., Care, A. S., & Moldenhauer, L. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122182 · Cited by 462
Metadata
- Authors
- Tilburgs, T., Crespo, Â. C., van der Zwan, A., Rybalov, B., Raj, T., Stranger, B., Gardner, L., Moffett, A., & Strominger, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-05-26
- Volume
- 112
- Issue
- 23
- Pages
- 7219-7224
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1533471141
- Cited by
- 199
- References
- 0
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. https://app.cochat.ai/papers/10.1073/pnas.1507977112
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- Tilburgs, T., Crespo, Â. C., van der Zwan, A., Rybalov, B., Raj, T., Stranger, B., Gardner, L., Moffett, A., & Strominger, J. L. (2015). Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1507977112
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