The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer
Open accessAbstract
Significance: In humans and genetically engineered mouse models (GEMs), the development of pancreatic ductal adenocarcinoma (PDAC) is accompanied by intimate neural–tumor interactions. Using a PDAC GEM that phenocopies the human disease, we found that many changes in peripheral and central nervous systems, indicative of injury and inflammation, arise at time points prior to overt tumor formation. Ablation of sensory neurons that innervate the pancreas, via neonatal capsaicin treatment, prevented neurogenic inflammation and delayed tumor formation. The slowing of PDAC in capsaicin-treated mice suggests the nervous system is not a bystander with respect to disease progression. Further studies are warranted to examine nervous system–tumor interactions and to identify potential targets for early detection, prevention, and treatment.
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Cites
EMT and Dissemination Precede Pancreatic Tumor Formation
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Self-citationAutonomic nerve development contributes to prostate cancer progression
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EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
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Cited by
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Adrenergic nerves activate an angio-metabolic switch in prostate cancer
Zahalka, A. H., Arnal-Estapé, A., Maryanovich, M., Nakahara, F., Cruz, C. D., Finley, L. W. S., & Frenette, P. S. (2017) · Science · doi:10.1126/science.aah5072 · Cited by 548
β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
Renz, B. W., Takahashi, R., Tanaka, T., Macchini, M., Hayakawa, Y., Dantes, Z., Maurer, H. C., Chen, X., Jiang, Z., Westphalen, C. B., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.11.007 · Cited by 543
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Nociceptor neurons affect cancer immunosurveillance
Balood, M., Ahmadi, M., Eichwald, T., Ahmadi, A., Majdoubi, A., Roversi, K., Roversi, K., Lucido, C. T., Restaino, A. C., Huang, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05374-w · Cited by 369
Metadata
- Authors
- Saloman, J. L., Albers, K. M., Li, D., Hartman, D. J., Crawford, H. C., Muha, E. A., Rhim, A. D., & Davis, B. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-02-29
- Volume
- 113
- Issue
- 11
- Pages
- 3078-3083
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2291931403
- Cited by
- 408
- References
- 70
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Saloman, J. L., Albers, K. M., Li, D., Hartman, D. J., Crawford, H. C., Muha, E. A., Rhim, A. D., & Davis, B. M. (2016). Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1512603113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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