The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets
Open accessAbstract
Significance: In activated platelets, a scramblase(s) scrambles phospholipids at plasma membranes and exposes phosphatidylserine (PtdSer) to the surface. PtdSer on activated platelets serves as a scaffold for the tenase and prothrombinase complexes for blood coagulation. Among five transmembrane protein 16 (TMEM16) members that support Ca 2+ -dependent phospholipid scrambling, TMEM16F is highly expressed in mouse platelets, and is indispensable for activation-induced PtdSer exposure and microparticle shedding. Thus, the rate of platelet-induced thrombin generation is severely reduced by the TMEM16F deficiency. The role of TMEM16F in PtdSer exposure on aggregated platelets is also shown in vivo with laser-induced thrombus formation. The phenotypes of TMEM16F -null mice resemble those of patients with Scott syndrome, a mild bleeding disorder, indicating that these mice provide a good model for this disease.
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Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781
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Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401
Self-citation
Cited by
Exposure of phosphatidylserine on the cell surface
Nagata, S., Suzuki, J., Segawa, K., & Fujii, T. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2016.7 · Cited by 512
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Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459
Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane
Bevers, E. M., & Williamson, P. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00020.2015 · Cited by 447
Marcoux, G., Magron, A., Sut, C., Laroche, A., Laradi, S., Hamzeh‐Cognasse, H., Allaeys, I., Cabon, O., Julien, A., Garraud, O., et al. (2019) · Transfusion · doi:10.1111/trf.15300 · Cited by 87
Metadata
- Authors
- Fujii, T., Sakata, A., Nishimura, S., Eto, K., & Nagata, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-09-28
- Volume
- 112
- Issue
- 41
- Pages
- 12800-12805
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2197048458
- Cited by
- 252
- References
- 2
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Fujii, T., Sakata, A., Nishimura, S., Eto, K., & Nagata, S. (2015). TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1516594112
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