The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Identification of tissue-specific cell death using methylation patterns of circulating DNA
Open accessAbstract
Significance: We describe a blood test for detection of cell death in specific tissues based on two principles: ( i ) dying cells release fragmented DNA to the circulation, and ( ii ) each cell type has a unique DNA methylation pattern. We have identified tissue-specific DNA methylation markers and developed a method for sensitive detection of these markers in plasma or serum. We demonstrate the utility of the method for identification of pancreatic β-cell death in type 1 diabetes, oligodendrocyte death in relapsing multiple sclerosis, brain cell death in patients after traumatic or ischemic brain damage, and exocrine pancreas cell death in pancreatic cancer or pancreatitis. The approach allows minimally invasive monitoring of tissue dynamics in humans in multiple physiological and pathological conditions.
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Cites
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
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Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
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International trial of the Edmonton protocol for islet transplantation
Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942
Self-citationNon-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
Murtaza, M., Dawson, S.-J., Tsui, D. W. Y., Gale, D., Forshew, T., Piskorz, A. M., Parkinson, C., Chin, S.-F., Kingsbury, Z., Wong, A. S. C., et al. (2013) · Nature · doi:10.1038/nature12065 · Cited by 1,624
Role of the Blood–Brain Barrier in Multiple Sclerosis
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“Both are autoimmune diseases in which oligodendrocyte and astrocyte cell death occurs and in which the blood–brain barrier is disrupted (28, 29).”
BackgroundRandall, J., Mörtberg, E., Provuncher, G. K., Fournier, D. R., Duffy, D. C., Rubertsson, S., Blennow, K., Zetterberg, H., & Wilson, D. H. (2013) · Resuscitation · doi:10.1016/j.resuscitation.2012.07.027 · Cited by 230 · cited 1×
“Following cardiac arrest, patients with documented ischemic brain damage sampled at multiple time points (n = 10 patients, 60 samples) (31) all had high levels of unmethylated Brain1 in serum (Fig.”
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Cited by
A view on drug resistance in cancer
Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770
Liquid biopsies come of age: Towards implementation of circulating tumour DNA
Wan, J. C. M., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J. D., Caldas, C., Pacey, S., Baird, R., & Rosenfeld, N. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.7 · Cited by 2,809
Current and future perspectives of liquid biopsies in genomics-driven oncology
Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0071-5 · Cited by 1,557
Sensitive tumour detection and classification using plasma cell-free DNA methylomes
Shen, S. Y., Singhania, R., Fehringer, G., Chakravarthy, A., Roehrl, M. H. A., Chadwick, D., Zuzarte, P. C., Borgida, A., Wang, T. T., Li, T., et al. (2018) · Nature · doi:10.1038/s41586-018-0703-0 · Cited by 983
Origins, structures, and functions of circulating DNA in oncology
Thierry, A. R., El Messaoudi, S., Gahan, P. B., Anker, P., & Stroun, M. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9629-x · Cited by 818
Metadata
- Authors
- Lehmann-Werman, R., Neiman, D., Zemmour, H., Moss, J., Magenheim, J., Vaknin-Dembinsky, A., Rubertsson, S., Nellgård, B., Blennow, K., Zetterberg, H., Spalding, K., Haller, M. J., Wasserfall, C. H., Schatz, D. A., Greenbaum, C. J., Dorrell, C., Grompe, M., Zick, A., Hubert, A., Maoz, M., Fendrich, V., Bartsch, D. K., Golan, T., Ben Sasson, S. A., Zamir, G., Razin, A., Cedar, H., Shapiro, A. M. J., Glaser, B., Shemer, R., & Dor, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-03-14
- Volume
- 113
- Issue
- 13
- Pages
- E1826-34
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2298824325
- Cited by
- 610
- References
- 9
- FWCI
- 25.60
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Lehmann-Werman, R., Neiman, D., Zemmour, H., Moss, J., Magenheim, J., Vaknin-Dembinsky, A., Rubertsson, S., Nellgård, B., Blennow, K., Zetterberg, H., Spalding, K., Haller, M. J., Wasserfall, C. H., Schatz, D. A., Greenbaum, C. J., Dorrell, C., Grompe, M., Zick, A., Hubert, A., . . . Dor, Y. (2016). Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1519286113
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
