The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
CREB pathway links PGE2 signaling with macrophage polarization
Open accessAbstract
Significance: The second messenger cAMP exerts potent immunosuppressive effects on the innate immune system, in part by activating class IIa histone deacetylases, and thereby inhibiting NF-κB–dependent transcription. We found that cAMP also promotes M2 macrophage polarization by stimulating the cyclic AMP-responsive element binding (CREB)/cAMP-regulated transcriptional coactivators TORC1 pathway. In the setting of acute overnutrition, macrophage CREB inhibits the production of inflammatory mediators and contributes to the maintenance of insulin sensitivity.
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Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
A central role for JNK in obesity and insulin resistance
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Transcriptional regulation of macrophage polarization: enabling diversity with identity
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IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038
Krüppel-like factor 4 regulates macrophage polarization
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The cancer metabolic reprogramming and immune response
Xia, L., Oyang, L., Lin, J., Tan, S., Han, Y., Wu, N., Yi, P., Tang, L., Pan, Q., Rao, S., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01316-8 · Cited by 1,312
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
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Musso, G., Cassader, M., Paschetta, E., & Gambino, R. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.031 · Cited by 332
Wu, J., Zhang, L., Shi, J., He, R., Yang, W., Habtezion, A., Niu, N., Lu, P., & Xue, J. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102920 · Cited by 189
Metadata
- Authors
- Luan, B., Yoon, Y.-S., Le Lay, J., Kaestner, K. H., Hedrick, S., & Montminy, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-12-07
- Volume
- 112
- Issue
- 51
- Pages
- 15642-15647
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2190420537
- Cited by
- 280
- References
- 9
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
