The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
CREB pathway links PGE2 signaling with macrophage polarization
Open accessAbstract
Significance: The second messenger cAMP exerts potent immunosuppressive effects on the innate immune system, in part by activating class IIa histone deacetylases, and thereby inhibiting NF-κB–dependent transcription. We found that cAMP also promotes M2 macrophage polarization by stimulating the cyclic AMP-responsive element binding (CREB)/cAMP-regulated transcriptional coactivators TORC1 pathway. In the setting of acute overnutrition, macrophage CREB inhibits the production of inflammatory mediators and contributes to the maintenance of insulin sensitivity.
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Metadata
- Authors
- Luan, B., Yoon, Y.-S., Le Lay, J., Kaestner, K. H., Hedrick, S., & Montminy, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-12-07
- Volume
- 112
- Issue
- 51
- Pages
- 15642-15647
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2190420537
- Cited by
- 280
- References
- 9
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- green
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