HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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A key driver to promote HCC: Cellular crosstalk in tumor microenvironment

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N6-methyladenosine (m6A) in cancer stem cell: From molecular mechanisms to therapeutic implications

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Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice

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The regulation of CD47-SIRPα signaling axis by microRNAs in combination with conventional cytotoxic drugs together with the help of nano-delivery: a choice for therapy?

Beizavi, Z., Hayat, S. M. G., Moghadasian, H., Zare, H., Yeganeh, B. S., Askari, H., Vakili, S., Tajbakhsh, A., & Savardashtaki, A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06547-y · Cited by 23

Oncolytic vaccinia virus armed with anti-CD47 nanobody elicit potent antitumor effects on multiple tumor models via enhancing innate and adoptive immunity

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Paraquat treatment modulates integrin associated protein (CD47) and basigin (CD147) expression and mitochondrial potential on erythroid cells in mice

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MicroRNA‐200a Promotes Phagocytosis of Macrophages and Suppresses Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma by Targeting CD47

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Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells

Chang, C., Wu, C.-C., Hsu, Y.-T., & Hsu, Y. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1803530 · Cited by 22

Pharmacological targets of breast cancer stem cells: a review

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Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

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CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions

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Co-expression of PD-L1 and HIF-1α predicts poor prognosis in Patients with Non-small Cell Lung Cancer after surgery

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Knockdown of LMNB1 Inhibits the Proliferation of Lung Adenocarcinoma Cells by Inducing DNA Damage and Cell Senescence

Li, J., Sun, Z., Cui, Y., Qin, L., Wu, F., Li, Y., Du, N., & Li, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.913740 · Cited by 23

Complex interaction and heterogeneity among cancer stem cells in head and neck squamous cell carcinoma revealed by single-cell sequencing

Xiao, M., Zhang, X., Zhang, D., Deng, S., Zheng, A., Du, F., Shen, J., Lin, Y., Yi, T., Xiao, Z., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1050951 · Cited by 22

Biomimetic Nanobomb for Synergistic Therapy with Inhibition of Cancer Stem Cells

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Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)

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CD47 as a potent target in cancer immunotherapy: A review

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Roles of TSP1-CD47 signaling pathway in senescence of endothelial cells: cell cycle, inflammation and metabolism

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RNA m6A modifications regulate crosstalk between tumor metabolism and immunity

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CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells

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Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer

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Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer

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CpG‐Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2‐Mediated Remodeling of Tumor‐Associated Macrophages

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Targeting the CD47-SIRPα signaling axis: current studies on B-cell lymphoma immunotherapy

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Novel immunotherapy for gastric cancer: targeting the CD47–SIRPα axis

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The Role of Metabolism in Tumor Immune Evasion: Novel Approaches to Improve Immunotherapy

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Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

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Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

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Hypoxia: Intriguing Feature in Cancer Cell Biology

Chowdhury, M., & Das, P. K. (2024) · ChemMedChem · doi:10.1002/cmdc.202300551 · Cited by 18

The Physiological and Therapeutic Role of CD47 in Macrophage Function and Cancer

Bess, S. N., Igoe, M. J., & Muldoon, T. J. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2415409 · Cited by 18

The Expression Pattern of Hypoxia-Related Genes Predicts the Prognosis and Mediates Drug Resistance in Colorectal Cancer

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Targeting Myeloid Checkpoint Molecules in Combination With Antibody Therapy: A Novel Anti-Cancer Strategy With IgA Antibodies?

Chan, C., Lustig, M., Baumann, N., Valerius, T., van Tetering, G., & Leusen, J. H. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932155 · Cited by 17

Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata

Erdem, N., Chen, K.-T., Qi, M., Zhao, Y., Wu, X., Garcia, I., Ku, H. T., Montero, E., Al-Abdullah, I. H., KANDEEL, F. R., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00221.2022 · Cited by 17

Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases

Dou, M., Chen, Y., Hu, J., Ma, D., & Xing, Y. (2020) · BioMed Research International · doi:10.1155/2020/4749135 · Cited by 17

Immunotherapeutic strategies for the treatment of ovarian cancer: current status and future direction

Duwa, R., Jeong, J., & Yook, S. (2020) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2020.11.015 · Cited by 17

UCA1 Overexpression Promotes Hypoxic Breast Cancer Cell Proliferation and Inhibits Apoptosis via HIF-1α Activation

Choudhry, H. (2021) · Journal of Oncology · doi:10.1155/2021/5512156 · Cited by 17

The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality?

Janji, B., & Chouaı̈b, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.880810 · Cited by 18

Genetically engineered nanomodulators elicit potent immunity against cancer stem cells by checkpoint blockade and hypoxia relief

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Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response

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miR-222 enhances radiosensitivity of cancer cells by inhibiting the expression of CD47.

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Blockade of CD47 enhances the antitumor effect of macrophages in renal cell carcinoma through trogocytosis

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The molecular basis of immuno-radiotherapy

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BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells

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Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer

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Sonodynamic Therapy Promotes Efferocytosis via CD47 Down-Regulation in Advanced Atherosclerotic Plaque

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The role of hypoxia-inducible factors in breast cancer stem cell specification

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Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation

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Conducive target range of breast cancer: Hypoxic tumor microenvironment

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Exploring the interplay between triple‐negative breast cancer stem cells and tumor microenvironment for effective therapeutic strategies

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Targeting immune checkpoints on myeloid cells: current status and future directions

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Hypoxia-Related Signature Is a Prognostic Biomarker of Pancreatic Cancer

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Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses

Li, S., Chen, Y., Ma, R., Du, Y., & Han, B. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1142374 · Cited by 14

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

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Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3

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Associations between HIFs and tumor immune checkpoints: mechanism and therapy

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Blocking CD47 Shows Superior Anti-tumor Therapeutic Effects of Bevacizumab in Gastric Cancer

Shi, C., Li, J., Fan, G., & Liu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.880139 · Cited by 13

Therapeutic modulation of the CD47-SIRPα axis in the pediatric tumor microenvironment: working up an appetite

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Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy

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RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

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Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche

de Oliveira, K. G., Bång-Rudenstam, A., Beyer, S., Boukredine, A., Hugo Talbot, A., Governa, V., Johansson, M. C., Månsson, A., Forsberg‐Nilsson, K., Bengzon, J., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01740-z · Cited by 12

Smart multi‐functional aggregates reoxygenate tumor microenvironment through a two‐pronged strategy to revitalize cancer immunotherapy

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A perspective on tumor radiation resistance following high-LET radiation treatment

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Prognostic implications of combined high expression of CD47 and MCT1 in breast cancer: a retrospective study during a 10-year period

Sun, Y., Liang, S., Li, T., Peng, C., Yang, Y., Lin, Y., Ma, Y., & Dong, C. (2022) · Translational Cancer Research · doi:10.21037/tcr-21-1951 · Cited by 12

Tailoring therapies to counter the divergent immune landscapes of breast cancer

Attalla, S. S., Taifour, T., & Muller, W. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1111796 · Cited by 13

Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

Maralbashi, S., Aslan, C., Kahroba, H., Asadi, M., Soltani‐Zangbar, M. S., Haghnavaz, N., Jadidi, F., Salari, F., & Kazemi, T. (2024) · BMC Nutrition · doi:10.1186/s40795-024-00844-y · Cited by 11

Emerging Immunotherapy Targets in Early Drug Development

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Development of Novel CD47-Specific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo

Chiang, Z.-C., Fang, S., Shen, Y., Cui, D., Weng, H., Wang, D., Zhao, Y., Lin, J., & Chen, Q. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.857927 · Cited by 11

CD47 expression and tumor-associated immune cells in breast cancer and their correlation with molecular subtypes and prognostic factors

Çelepli, P., Karabulut, Ş., BİGAT, İ., Celepli, S., & Hücümenoğlu, S. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154107 · Cited by 12

Preparation and evaluation of dabrafenib-loaded, CD47-conjugated human serum albumin-based nanoconstructs for chemoimmunomodulation

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Each pregnancy linearly changes immune gene expression in the blood of healthy women compared with breast cancer patients

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Role of CD47 gene expression in colorectal cancer: a comprehensive molecular profiling study

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Cancer stem cells: advances in biology and clinical translation—a Keystone Symposia report

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Improving the synergistic combination of programmed death‐1/programmed death ligand‐1 blockade and radiotherapy by targeting the hypoxic tumour microenvironment

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Merkel Cell Carcinoma and Immune Evasion: Merkel Cell Polyomavirus Small T-Antigen‒Induced Surface Changes Can Be Reverted by Therapeutic Intervention

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Fate decisions of breast cancer stem cells in cancer progression

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Role of Hypoxia and Rac1 Inhibition in the Metastatic Cascade

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The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis

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The pivotal role of cytotoxic NK cells in mediating the therapeutic effect of anti-CD47 therapy in mycosis fungoides

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缺氧诱导因子（HIF）与肝癌发展预后的综述

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Modulating macrophage-mediated programmed cell removal: An attractive strategy for cancer therapy

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Cancer stem cells: Masters of all traits

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Tumor hypoxia shapes natural killer cell anticancer activities

Retamal, M. A., Salazar‐Onfray, F., González, F. E., & Tittarelli, A. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02557-6 · Cited by 10

Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy

Semenza, G. L. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100075 · Cited by 10

In Vitro Assays of Breast Cancer Stem Cells

Samanta, D., & Semenza, G. L. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7665-2_21 · Cited by 9

A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment

Chen, A., Yang, F., Kuang, J., Xiong, Y., Mi, B., Zhou, Y., Hu, J., Song, S., Wan, T. Y., Wan, Z., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c15025 · Cited by 9

Identification of Immune-Related Breast Cancer Chemotherapy Resistance Genes via Bioinformatics Approaches

Du, Y., Han, Y., Wang, X., Wang, H., Qu, Y., Guo, K., Ma, W., & Fu, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.772723 · Cited by 9

Prognostic significance of CKS2 and CD47 expression in patients with gastric cancer who underwent radical gastrectomy

Zhou, Y., Zeng, J., Zhou, W., Wu, K., Tian, Z., & Shen, W. (2022) · Scandinavian Journal of Immunology · doi:10.1111/sji.13198 · Cited by 9

NDR1 activates CD47 transcription by increasing protein stability and nuclear location of ASCL1 to enhance cancer stem cell properties and evasion of phagocytosis in small cell lung cancer

Wang, L., Wan, X.-Y., Wang, T.-L., Liu, C.-Q., & Zheng, F.-M. (2022) · Medical Oncology · doi:10.1007/s12032-022-01859-w · Cited by 8

Are Cancer Stem Cells a Suitable Target for Breast Cancer Immunotherapy?

Ruiu, R., Lorenzo, A. D., Cavallo, F., & Conti, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.877384 · Cited by 9

Tristetraprolin regulates phagocytosis through interaction with CD47 in head and neck cancer

Lee, W., Kim, S. Y., An, J.-J., Kim, T.-K., Cha, H. J., Chang, H., Kim, S. Y., Kim, S. M., & Han, M. W. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11478 · Cited by 9

Understanding the regulation of “Don’t Eat-Me” signals by inflammatory signaling pathways in the tumor microenvironment for more effective therapy

Karizak, A. Z., Salmasi, Z., Hayat, S. M. G., Asadi, M., Ghasemi, Y., Tajbakhsh, A., & Savardashtaki, A. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04452-w · Cited by 9

Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance

Malik, S., Sikander, M., Wahid, M., Dhasmana, A., Sarwat, M., Khan, S., Cobos, E., Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10177-8 · Cited by 9

Restoration of miR ‐299‐3p promotes efferocytosis and ameliorates atherosclerosis via repressing CD47 in mice

Zhu, Y., Ren, S., Huang, H., Wu, J., You, X., Gao, J., Ren, Y., Wang, R., Zhao, W., & Tan, S. (2024) · The FASEB Journal · doi:10.1096/fj.202400639r · Cited by 8

Decoding the Tumor Microenvironment: Insights and New Targets from Single-Cell Sequencing and Spatial Transcriptomics

Pattabiram, S., Gangadaran, P., Dhayalan, S., Chatterjee, G., Reyaz, D., Prakash, K., Arun, R., Rajendran, R. L., Ahn, B., & ArulJothi, K. N. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090730 · Cited by 11

ICAM‐1‐Expressing Extracellular Vesicles Enable Sequential Delivery Barrier‐Breaking and Microenvironment Modulating for Glioblastoma Stem Cell Inhibition

Liang, F., You, Q., Wang, H., Liu, J., Yang, Q., Lu, D., Ma, X., Wang, C., He, Z., Yang, Y., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202408006 · Cited by 8

Multiple Dynamics in Tumor Microenvironment Under Radiotherapy

Huang, J., & Li, J. J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-44518-8_10 · Cited by 9

CD47 is highly expressed in gliomas and targeting CD47 is a promising therapeutic strategy

Yang, J., Yao, Y., Li, T., Zhu, Z., Wang, L., & Yang, J.-J. (2021) · European Journal of Inflammation · doi:10.1177/20587392211000899 · Cited by 8

ID: 1077 Overexpress of CD47 does not alter stemness of MCF-7 breast cancer cells

Nguyen, O. T.-K., Bui, A. N.-T., Vu, N. B., & Pham, P. V. (2017) · Biomedical Research and Therapy · doi:10.15419/bmrat.v4is.351

Overexpress of CD47 does not alter the stemness of MCF-7 breast cancer cells

Nguyen, O. T.-K., Bui, A. N.-T., Vu, N. B., & Pham, P. V. (2016) · Biomedical Research and Therapy · doi:10.7603/s40730-016-0044-2 · Cited by 2

HIF-2α regulates CD44 to promote cancer stem cell activation in triple-negative breast cancer via PI3K/AKT/mTOR signaling

Bai, J., Chen, W., Zhang, X., Kang, X.-N., Jin, L., Zhang, H., & Wang, Z. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i1.87 · Cited by 74

Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)

Wu, F., Pang, H., Li, F., Hua, M., Song, C., & Tang, J. (2024) · Oncology Letters · doi:10.3892/ol.2024.14389 · Cited by 22

Expression of Concern: Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors

Semenza, G. L. (2026) · Clinical Science · doi:10.1042/cs20150451_eoc