The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Open accessAbstract
Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“hypoxic tumor cells evade innate immune recognition through the up-regulation of CD47, a cell surface molecule that interacts with signal regulatory protein alpha (SIRP α) on the surface of macrophages to block phagocytosis”
From Hypoxic control of metastasis (2016) · cites this paper as [58]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
7 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
RetractedSamanta, D., Gilkes, D. M., Chaturvedi, P., Xiang, L., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421438111 · Cited by 460
Self-citationRetractedRETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
Lee, K., Zhang, H., Qian, D. Z., Rey, S., Liu, J. O., & Semenza, G. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909353106 · Cited by 451
Self-citationRetractedZhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., et al. (2012) · Oncogene · doi:10.1038/onc.2011.365 · Cited by 326
Self-citationRetractedRETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296
Self-citationRetractedProcollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252
Self-citationRetractedGilkes, D. M., Xiang, L., Lee, S. J., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321510111 · Cited by 184
Self-citationRetractedPD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,239
Comprehensive molecular portraits of human breast tumours
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129
Cited by
Sorted by citations
Items 101–200 of 425
Hypoxia as a Modulator of Inflammation and Immune Response in Cancer
Castillo‐Rodríguez, R. A., Trejo‐Solís, C., Cabrera‐Cano, A., Gómez‐Manzo, S., & Dávila‐Borja, V. M. (2022) · Cancers · doi:10.3390/cancers14092291 · Cited by 70
Liang, J., Jin, X., Luo, G., Zhang, S., Huang, Q., Lin, Y.-T., Deng, X., Wang, J., Chen, W., & Zhang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c05093 · Cited by 69
How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia
Mirchandani, A. S., Sánchez-García, M. A., & Walmsley, S. R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01087-5 · Cited by 77
Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development
Cheu, J. W.-S., Chiu, D. K.-C., Kwan, K. K.-L., Yang, C., Yuen, V. W.-H., Goh, C. C., Chui, N. N.-Q., Shen, W., Law, C.-T., Li, Q., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade5111 · Cited by 65
Tan, W., Tang, H., Jiang, X., Ye, F., Huang, L., Shi, D., Li, L., Huang, X., Li, L., Xie, X., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14462 · Cited by 65
Alvey, C. M., & Discher, D. E. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.4ri1216-516r · Cited by 65
Mapping the topography of spatial gene expression with interpretable deep learning
Chitra, U., Arnold, B. J., Sarkar, H., Sanno, K., Ma, C., Lopez-Darwin, S. L., & Raphael, B. J. (2025) · Nature Methods · doi:10.1038/s41592-024-02503-3 · Cited by 64
Hu, L., Zhuang, W., Chen, M.-J., Liao, J., Wu, D., Zhang, Y., Pang, L., Huang, Y., Mao, T.-Q., Yang, M., et al. (2024) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2024.03.019 · Cited by 64
Leptin signaling and cancer chemoresistance: Perspectives
Candelaria, P. V., Rampoldi, A., Harbuzariu, A., & Gonzalez-Perez, R. R. (2017) · World Journal of Clinical Oncology · doi:10.5306/wjco.v8.i2.106 · Cited by 61
Jiang, Z., Hsu, J. L., Li, Y., Hortobágyi, G. N., & Hung, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01197 · Cited by 62
Long non-coding RNAs in cancer stem cells
Schwerdtfeger, M., Desiderio, V., Kobold, S., Regad, T., Zappavigna, S., & Caraglia, M. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101134 · Cited by 58
Du, L., Su, Z., Wang, S., Meng, Y., Xiao, F., Xu, D., Li, X., Qian, X., Lee, S. B., Lee, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202206380 · Cited by 61
Feliz‐Mosquea, Y. R., Christensen, A. A., Wilson, A. S., Westwood, B. M., Varagić, J., Meléndez, G. C., Schwartz, A. L., Chen, Q., Griner, L. A. M., Guha, R., et al. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4884-x · Cited by 58
Ghosh, R., Samanta, P., Sarkar, R., Biswas, S., Saha, P., Hajra, S., & Bhowmik, A. (2022) · Molecules · doi:10.3390/molecules27165192 · Cited by 65
Liu, Y., Xu, D., Liu, Y., Zheng, X. W., Zang, J., Ye, W., Zhao, Y., He, R., Ruan, S., Zhang, T., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121516 · Cited by 55
Hypoxia-Regulated Tumor-Derived Exosomes and Tumor Progression: A Focus on Immune Evasion
Shao, X., Hua, S., Feng, T., Ocansey, D. K. W., & Yin, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911789 · Cited by 60
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes
Kosaka, A., Ishibashi, K., Nagato, T., Kitamura, H., Fujiwara, Y., Yasuda, S., Nagata, M., Harabuchi, S., Hayashi, R., Yajima, Y., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200792 · Cited by 58
Luo, S., Yang, G., Ye, P., Cao, N., Chi, X., Yang, W., & Yan, X. (2022) · Biomolecules · doi:10.3390/biom12060850 · Cited by 54
CD47 Promotes Human Glioblastoma Invasion Through Activation of the PI3K/Akt Pathway
Liu, X., Wu, X., Wang, Y., Li, Y., Chen, X., Yang, W., & Jiang, L. (2018) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504018x15155538502359 · Cited by 53
Hypoxic Signalling in Tumour Stroma
Laitala, A., & Erler, J. T. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00189 · Cited by 55
The CD47-SIRPα axis is a promising target for cancer immunotherapies
Hao, Y., Zhou, X., Li, Y., Li, B., & Lei, C. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110255 · Cited by 54
Glioblastoma Immunotherapy Targeting the Innate Immune Checkpoint CD47-SIRPα Axis
Hu, J., Xiao, Q., Dong, M., Guo, D., Wu, X., & Wang, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.593219 · Cited by 51
Stirling, E. R., Terabe, M., Wilson, A. S., Kooshki, M., Yamaleyeva, L. M., Alexander‐Miller, M. A., Zhang, W., Miller, L. D., Triozzi, P. L., & Soto‐Pantoja, D. R. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004712 · Cited by 52
Giatromanolaki, A. N., Harris, A. L., Banham, A. H., Contrafouris, C., & Koukourakis, M. I. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0756-3 · Cited by 51
Martori, C., Sánchez-Moral, L., Paul, T., Pardo, J. C., Pous, A. F., de Porras, V. R., & Sarrias, M. (2022) · Cancers · doi:10.3390/cancers14020440 · Cited by 49
Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients
Yuan, J., He, H., Chen, C., Wu, J., Rao, J., & Yan, H. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0957-0 · Cited by 52
Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells
Alhabbab, R. Y. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00312 · Cited by 51
Intratumoral hypoxia and mechanisms of immune evasion mediated by hypoxia-inducible factors
Semenza, G. L. (2021) · Physiology · doi:10.1152/physiol.00034.2020 · Cited by 64
Self-citationRole of HIF-1α in the Responses of Tumors to Radiotherapy and Chemotherapy
Song, C. W., Kim, H., Kim, M.-S., Park, H. J., Paek, S.-H., Terezakis, S. A., & Cho, L. C. (2024) · Cancer Research and Treatment · doi:10.4143/crt.2024.255 · Cited by 58
BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma
Liu, F., Jiang, C. C., Yan, X. G., Tseng, H., Wang, C. Y., Zhang, Y. Y., Yari, H., La, T., Farrelly, M. L., Guo, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17704 · Cited by 50
Role of Tumor Microenvironment in Cancer Stem Cells Resistance to Radiotherapy
Taeb, S., Ashrafizadeh, M., Zarrabi, A., Rezapoor, S., Musa, A. E., Farhood, B., & Najafi, M. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009622666211224154952 · Cited by 49
Guo, Z., Liu, Y., Zhou, H., Zheng, K., Wang, D., Jia, M., Xu, P., Ma, K., Cui, C., & Wang, L. (2019) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2019.110546 · Cited by 48
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes
Roberts, D. D., & Isenberg, J. S. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00175.2021 · Cited by 50
Jiang, C., Sun, H., Jiang, Z., Tian, W., Cang, S., & Yu, J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1378647 · Cited by 48
Bridging angiogenesis and immune evasion in the hypoxic tumor microenvironment
Schito, L. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00209.2018 · Cited by 49
Gui, C., Wei, J., Chen, Y., Fu, L., Tang, Y., Cao, J., Chen, W., & Luo, J. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab173 · Cited by 46
Metabolic Reprogramming in the Tumor Microenvironment With Immunocytes and Immune Checkpoints
Xu, Y., He, L., Fu, Q., & Hu, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.759015 · Cited by 51
Wang, X., Ren, H., Zhao, T., Ma, W., Dong, J., Zhang, S., Xin, W., Yang, S., Jia, L., & Hao, J. (2016) · Oncotarget · doi:10.18632/oncotarget.7263 · Cited by 46
The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation
Trivanović, D. I., Krstić, J., Djordjević, I. O., Mojsilović, S. B., Santibanez, J. F., Bugarski, D. S., & Jauković, A. (2016) · Mediators of Inflammation · doi:10.1155/2016/7314016 · Cited by 51
Luteolin impairs hypoxia adaptation and progression in human breast and colon cancer cells
Monti, E., Marras, E., Prini, P., & Gariboldi, M. B. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173210 · Cited by 47
Targeting the Tumor Microenvironment: A Close Up of Tumor-Associated Macrophages and Neutrophils
Russo, M., & Nastasi, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.871513 · Cited by 45
Targeting intratumoral hypoxia to enhance anti-tumor immunity
Semenza, G. L. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.09.002 · Cited by 47
Self-citationImmunotargeting of Cancer Stem Cells
Köseer, A. S., Gaetano, S. D., Arndt, C., Bachmann, M. P., & Dubrovska, A. (2023) · Cancers · doi:10.3390/cancers15051608 · Cited by 47
Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications
Wang, L., Jin, Z., Master, R. P., Maharjan, C. K., Carelock, M. E., Reccoppa, T. B. A., Kim, M., Kolb, R. H., & Zhang, W. (2022) · Cancers · doi:10.3390/cancers14133287 · Cited by 46
Redox regulation of cancer stem cells: Biology and therapeutic implications
Du, M., Zhang, J., Wicha, M. S., & Luo, M. (2024) · MedComm – Oncology · doi:10.1002/mog2.70005 · Cited by 45
Anticancer effects of anti-CD47 immunotherapy in vivo
Iribarren, K., Buqué, A., Mondragón, L., Xie, W., Lévesque, S., Pol, J. G., Zitvogel, L., Kepp, O., & Kroemer, G. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1550619 · Cited by 46
Regulation of CD47 expression by interferon-gamma in cancer cells
Ye, Z.-H., Jiang, X., Huang, M., Xu, Y., Chen, Y., Yuan, L., Huang, C.-Y., Yu, W., Chen, X., & Lu, J. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101162 · Cited by 45
Kanamori, A., Matsubara, D., Saitoh, Y., Fukui, Y., Gotoh, N., Kaneko, S., Seiki, M., Murakami, Y., Inoue, J., & Sakamoto, T. (2020) · Oncogene · doi:10.1038/s41388-020-01423-8 · Cited by 44
Targeting hypoxia-inducible factors for breast cancer therapy: A narrative review
Luo, S., Jiang, Y., Zheng, A., Zhao, Y., Wu, X., Li, M., Du, F., Chen, Y., Deng, S., Chen, M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1064661 · Cited by 50
Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling
Kaur, S., & Roberts, D. D. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.05.005 · Cited by 43
Bhattacharya, S., Calar, K., Evans, C. M., Petrasko, M., & de la Puente, P. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.01040 · Cited by 39
Inflammation and Myeloid Cells in Cancer Progression and Metastasis
Deng, J., & Fleming, J. B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.759691 · Cited by 44
Catalán, R., Orozco‐Morales, M., Hernández‐Pedro, N., Güijosa, A., Colín-González, A. L., Ávila‐Moreno, F., & Arrieta, O. G. (2020) · Journal of Immunology Research · doi:10.1155/2020/9435030 · Cited by 40
Benoit, A., Vogin, G., Duhem, C., Berchem, G., & Janji, B. (2023) · Cells · doi:10.3390/cells12131787 · Cited by 39
“Emerging new data demonstrates that hypoxia is involved in the alteration of tumor metabolism and metabolites, pH regulation, and overexpression of several immune checkpoints including macrophage immune checkpoints CD47, PD-L1, and HLA-G [29,30,32,33].”
BackgroundCD47 promotes cell growth and motility in epithelial ovarian cancer
Wang, C., Lin, M., Hsu, C., Lin, H., Tsai, H., Long, C., Tsai, E., Hsieh, T., & Wu, C. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109105 · Cited by 39
Yu, L.-Y., Shueng, P., Chiu, H., Yen, Y.-W., Kuo, T.-Y., Li, C.-R., Liu, M., Ho, C.-H., Ho, T., Wang, B., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12123 · Cited by 38
Ali, R., Samman, N., Zahrani, H. A., Nehdi, A., Rahman, S., Khan, A. L., Balwi, M. A. A., Alriyees, L. A., Alzaid, M., Alaskar, A. S., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3812-5 · Cited by 38
Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment
Semenza, G. L. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac089 · Cited by 43
Self-citationCD47: The Next Frontier in Immune Checkpoint Blockade for Non-Small Cell Lung Cancer
Lau, A. P. Y., Binstock, S. S. K., & Thu, K. L. (2023) · Cancers · doi:10.3390/cancers15215229 · Cited by 39
Sulaiman, A., McGarry, S., Han, X., Liu, S., & Wang, L. (2019) · Cancers · doi:10.3390/cancers11081128 · Cited by 36
Kozal, K., & Krześlak, A. (2022) · Cancers · doi:10.3390/cancers14184518 · Cited by 37
Vishnubalaji, R., & Alajez, N. M. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.09.002 · Cited by 35
Nayak, V., Patra, S., Singh, K. R., Ganguly, B., Kumar, D. N., Panda, D., Maurya, G. K., Singh, J., Majhi, S., Sharma, R., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116573 · Cited by 37
Deng, C., Deng, G., Chu, H., Chen, S., Chen, X., Li, X., He, Y., Sun, C., & Zhang, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1140328 · Cited by 34
Self-citationNanocarrier based approaches for targeting breast cancer stem cells
Pindiprolu, S. K. S. S., Krishnamurthy, P. T., Chintamaneni, P. K., & Karri, V. V. S. R. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1366337 · Cited by 34
Miller, T. W., Amason, J., Garcin, E. D., Lamy, L., Dranchak, P. K., MacArthur, R., Braisted, J. C., Rubin, J. S., Burgess, T. L., Farrell, C. L., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218897 · Cited by 35
Zhang, X., Wu, L., Xu, Y., Yu, H. J., Chen, Y., Zhao, H., Lei, J., Zhou, Y. J., Zhang, J., Wang, J., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.03.027 · Cited by 34
The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia
Gallez, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.853568 · Cited by 35
Lee, S., Micalizzi, D. S., Truesdell, S. S., Bukhari, S. I. A., Boukhali, M., Story, J. L., Kato, Y., Choo, M., Dey‐Guha, I., Ji, F., et al. (2020) · Genome biology · doi:10.1186/s13059-020-1936-4 · Cited by 32
Xu, Y., Li, J., Tong, B., Chen, M., Liu, X., Zhong, W., Zhao, J., & Wang, M. (2020) · ESMO Open · doi:10.1136/esmoopen-2020-000823 · Cited by 33
Dai, X., Li, X., Liu, Y., & Yan, F. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.110656 · Cited by 34
Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment
Lappano, R., Todd, L. A., Stanic, M., Cai, Q., Maggiolini, M., Marincola, F., & Pietrobon, V. (2022) · Cancers · doi:10.3390/cancers14030539 · Cited by 32
Zhou, X., Yan, Z., Hou, J., Zhang, L., Chen, Z., Gao, C., Ahmad, N. H., Guo, M., Wang, W., Han, T., et al. (2024) · Oncogene · doi:10.1038/s41388-023-02923-z · Cited by 34
Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPα axis
Chen, X., Guo, C.-H., Wang, Z., Yang, Y., Pan, Y.-H., Liang, J.-Y., Sun, M.-G., Fan, L., Li, L., & Wang, W. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01450-4 · Cited by 32
Wu, C., Xu, T.-H., Zhang, H.-Y., Hu, Y., Jiao, J., Qiu, K., Gu, J., Li, W.-Y., & Sun, L. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217913 · Cited by 32
Self-citationLa, H. T., Tran, D. B. T., Tran, H. M., & Nguyen, L. T. (2021) · Journal of Immunology Research · doi:10.1155/2021/5575260 · Cited by 33
Si, Y., Zhang, Y., Guan, J.-S., Ngo, H. G., Totoro, A., Singh, A. P., Chen, K., Xu, Y., Yang, E. S.-H., Zhou, L., et al. (2021) · Vaccines · doi:10.3390/vaccines9080882 · Cited by 32
3D bioprinting technology to mimic the tumor microenvironment: tumor-on-a-chip concept
Samadian, H., Jafari, S., Sepand, M. R., Alaei, L., Malvajerd, S. S., Jaymand, M., Ghobadinezhad, F., Jahanshahi, F., Hamblin, M. R., Derakhshankhah, H., et al. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100160 · Cited by 33
Sadozai, H., Acharjee, A., Kayani, H. Z., Gruber, T., Gorczynski, R. M., & Burke, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1360629 · Cited by 32
Hypoxic tumor microenvironment: Destroyer of natural killer cell function
Zhang, Y., Guo, F., & Wang, Y. (2024) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2024.02.04 · Cited by 32
USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity
Dai, P., Sun, Y., Huang, Z., Liu, Y.-T., Gao, M., Liu, H.-M., Shi, J., He, C. H., Xiang, B., Yao, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59621-5 · Cited by 37
SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer
Hjelmeland, A. B., & Patel, R. P. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916214116 · Cited by 30
Tumour growth and immune evasion as targets for a new strategy in advanced cancer
Nicolini, A., Ferrari, P., Rossi, G., & Carpi, A. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0142 · Cited by 32
Targeting CD47 as a Novel Immunotherapy for Breast Cancer
Chen, C., Wang, R., Chen, X., Hou, Y., & Jiang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.924740 · Cited by 30
Blocking CD47-SIRPα Signal Axis as Promising Immunotherapy in Ovarian Cancer
Luo, X., Shen, Y., Huang, W., Bao, Y., Mo, J., Yao, L., & Yuan, L. (2023) · Cancer Control · doi:10.1177/10732748231159706 · Cited by 30
Kim, H., Lin, Q., & Yun, Z. (2019) · Scientific Reports · doi:10.1038/s41598-019-46210-y · Cited by 29
Role of Hypoxia in the Interferon Response
Arnaiz, E., & Harris, A. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.821816 · Cited by 28
Liu, Y., Li, M., Wei, C., Tang, L., Sheng, Y., Liu, Y., Li, D., Ding, D., Qiu, J., & Zhu, X. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13236 · Cited by 28
Hafny‐Rahbi, B. E., Brodaczewska, K. K., Collet, G., Majewska, A., Klimkiewicz, K., Delalande, A., Grillon, C., & Kiéda, C. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16399 · Cited by 27
Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity
Lin, H.-J. L., Liu, Y., Lofland, D., & Lin, J. (2022) · Cancers · doi:10.3390/cancers14020285 · Cited by 28
Overcoming immunotherapeutic resistance in PDAC: SIRPα-CD47 blockade
Alausa, A. O., Lawal, K. A., Babatunde, O. A., Obiwulu, E. N. O., Oladokun, O. C., Fadahunsi, O. S., Celestine, U. O., Moses, E. U., Akaniro, I. R., & Adegbola, P. I. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106264 · Cited by 29
Immunotherapy for HER-2 positive breast cancer
Yang, T., Kang, L., Li, D., & Song, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1097983 · Cited by 29
Leung, C. S., Li, J., Xu, F., Wong, A. S. L., & Lui, K. O. (2018) · The FASEB Journal · doi:10.1096/fj.201800449r · Cited by 27
Aria, H., Rezaei, M., Nazem, S., Daraei, A., Nikfar, G., Mansoori, B., Bahmanyar, M., Tavassoli, A., Vakil, M. K., & Mansoori, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947885 · Cited by 26
Liao, T., Chen, Y.-H., Li, Z.-Y., Hsiao, A.-C., Huang, Y.-L., Hao, R.-X., Tai, S., Chu, P., Shih, J.-W., Kung, H., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0622 · Cited by 27
Zaarour, R. F., Ribeiro, M., Azzarone, B. G., Kapoor, S., & Chouaı̈b, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1222575 · Cited by 25
Fan, Z., Zheng, W., Li, H., Wu, W., Liu, X., Sun, Z., Hu, H., Du, L., Jia, Q., & Liu, Q. (2020) · Oncology Reports · doi:10.3892/or.2020.7541 · Cited by 25
An antitumor peptide RS17‐targeted CD47, design, synthesis, and antitumor activity
Wang, X., Wang, Y., Hu, J., & Xu, H. (2021) · Cancer Medicine · doi:10.1002/cam4.3768 · Cited by 25
Mirzaei, S., Ranjbar, B., Tackallou, S. H., & Aref, A. R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154676 · Cited by 28
Lorestani, P., Dashti, M., Nejati, N., Habibi, M. A., Askari, M., Robat-Jazi, B., Ahmadpour, S., & Tavakolpour, S. (2024) · Discover Oncology · doi:10.1007/s12672-024-01256-x · Cited by 24
Metadata
- Authors
- Zhang, H., Lu, H., Xiang, L., Bullen, J. W., Zhang, C., Samanta, D., Gilkes, D. M., He, J., & Semenza, G. L.
- Affiliations
- Johns Hopkins University (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-10-28
- Volume
- 112
- Issue
- 45
- Pages
- E6215-23
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4653179
- OpenAlex
- W1853160207
- Cited by
- 420
- References
- 62
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 62 · 2023: 46 · 2022: 57 · 2021: 48 · 2020: 52 · 2019: 29 · 2018: 31 · 2017: 17 · 2016: 21 · 2015: 1
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-09-25)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society (122437-RP-12-090-01-COUN)
- U.S. Department of Defense (W81XWH-12-1-0464)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- HIF-1, CD47, breast cancer, phagocytosis evasion, macrophages, cancer stem cells, hypoxia, transcriptional regulation, mammospheres, patient mortality, prognostic factors
- MeSH terms
- Analysis of Variance, Breast Neoplasms, Female, Humans, Luciferases, Phagocytosis, Neoplastic Stem Cells, Immunoblotting, Gene Expression Regulation, Neoplastic, DNA Primers, Tumor Escape, RNA, Small Interfering, Cell Line, Tumor, Chromatin Immunoprecipitation, Hypoxia-Inducible Factor 1, CD47 Antigen, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review