Gilkes, Daniele M.

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 1,520

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 493

RETRACTED: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

Samanta, D., Gilkes, D. M., Chaturvedi, P., Xiang, L., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 460

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 437

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

Zhang, H., Lu, H., Xiang, L., Bullen, J. W., Zhang, C., Samanta, D., Gilkes, D. M., He, J., & Semenza, G. L. (2015) · Proceedings of the National Academy of Sciences

Phagocytosis and Immune RegulationCancer, Hypoxia, and Metabolism

Cited by 420

RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., et al. (2012) · Oncogene

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 326

RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 296

Role of hypoxia-inducible factors in breast cancer metastasis

Gilkes, D. M., & Semenza, G. L. (2013) · Future Oncology

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 274

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Chen, L., Gilkes, D. M., Pan, Y., Lane, W. S., & Chen, J. (2005) · The EMBO Journal

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 260

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 252

Hypoxia-Inducible Factors and Cancer

Jun, J. C., Rathore, A., Younas, H., Gilkes, D., & Polotsky, V. Y. (2017) · Current Sleep Medicine Reports

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 248

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin

Hu, B., Gilkes, D. M., Farooqi, B., Sebti, S. M., & Chen, J. (2006) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 236

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

Chaturvedi, P., Gilkes, D. M., Takano, N., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Immune cells in cancerCancer Cells and Metastasis

Cited by 226

RETRACTED: Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

Gilkes, D. M., Xiang, L., Lee, S. J., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCancer, Hypoxia, and Metabolism

Cited by 184

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2013) · Journal of Clinical Investigation

Cancer Cells and MetastasisCancer, Hypoxia, and Metabolism

Cited by 181

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Jayatilaka, H., Tyle, P., Chen, J. J., Kwak, M., Ju, J., Kim, H. J., Lee, J. S. H., Wu, P.-H., Gilkes, D. M., Fan, R., et al. (2017) · Nature Communications

Chemokine receptors and signalingCancer Cells and Metastasis

Cited by 177

Single-cell morphology encodes metastatic potential

Wu, P.-H., Gilkes, D. M., Phillip, J. M., Narkar, A., Cheng, T. W.-T., Marchand, J., Lee, M.-H., Li, R., & Wirtz, D. (2020) · Science Advances

Cancer Cells and MetastasisCell Image Analysis Techniques

Cited by 177

MDMX regulation of p53 response to ribosomal stress

Gilkes, D. M., Chen, L., & Chen, J. (2006) · The EMBO Journal

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 142

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3

LeBron, C., Chen, L., Gilkes, D. M., & Chen, J. (2006) · The EMBO Journal

Cancer-related Molecular Pathways14-3-3 protein interactions

Cited by 122

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H., & Semenza, G. L. (2014) · Oncotarget

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 119

A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Hubbi, M. E., Kshitiz, Gilkes, D. M., Rey, S., Wong, C. C., Luo, W., Kim, D.-H., Dang, C. V., Levchenko, A., & Semenza, G. L. (2013) · Science Signaling

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 116

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

Xiang, L., Gilkes, D. M., Chaturvedi, P., Luo, W., Hu, H., Takano, N., Liang, H., & Semenza, G. L. (2014) · Journal of Molecular Medicine

Cancer, Hypoxia, and MetabolismHeat shock proteins research

Cited by 114

Regulation of MDMX Expression by Mitogenic Signaling

Gilkes, D. M., Pan, Y., Coppola, D., Yeatman, T., Reuther, G. W., & Chen, J. (2008) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 82

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

Xiang, L., Gilkes, D. M., Hu, H., Luo, W., Bullen, J. W., Liang, H., & Semenza, G. L. (2015) · Oncotarget

Hippo pathway signaling and YAP/TAZCancer, Hypoxia, and Metabolism

Cited by 73