The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy
Open accessAbstract
Significance: Successively overcoming a series of biological barriers that cancer nanotherapeutics would encounter upon intravenous administration is required for achieving positive treatment outcomes. A hurdle to this goal is the inherently unfavorable tumor penetration of nanoparticles due to their relatively large sizes. We developed a stimuli-responsive clustered nanoparticle (iCluster) and justified that its adaptive alterations of physicochemical properties (e.g. size, zeta potential, and drug release rate) in accordance with the endogenous stimuli of the tumor microenvironment made possible the ultimate overcoming of these barriers, especially the bottleneck of tumor penetration. Results in varying intractable tumor models demonstrated significantly improved antitumor efficacy of iCluster than its control groups, demonstrating that overcoming these delivery barriers can be achieved by innovative nanoparticle design.
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Metadata
- Authors
- Li, H.-J., Du, J.-Z., Du, X.-J., Xu, C.-F., Sun, C.-Y., Wang, H.-X., Cao, Z.-T., Yang, X.-Z., Zhu, Y.-H., Nie, S., & Wang, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-03-28
- Volume
- 113
- Issue
- 15
- Pages
- 4164-4169
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2335076883
- Cited by
- 724
- References
- 12
- FWCI
- 37.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, H.-J., Du, J.-Z., Du, X.-J., Xu, C.-F., Sun, C.-Y., Wang, H.-X., Cao, Z.-T., Yang, X.-Z., Zhu, Y.-H., Nie, S., & Wang, J. (2016). Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1522080113
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