The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
Open accessAbstract
Synapses in the brain are bidirectionally modifiable, but the routes of induction are diverse. In various experimental paradigms, N -methyl- d -aspartate receptor-dependent long-term depression and long-term potentiation have been induced selectively by varying the membrane potential of the postsynaptic neurons during presynaptic stimulation of a constant frequency, the rate of presynaptic stimulation, and the timing of pre- and postsynaptic action potentials. In this paper, we present a mathematical embodiment of bidirectional synaptic plasticity that is able to explain diverse induction protocols with a fixed set of parameters. The key assumptions and consequences of the model can be tested experimentally; further, the model provides the foundation for a unified theory of N -methyl- d -aspartate receptor-dependent synaptic plasticity.
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Self-citationLong-Term Potentiation--A Decade of Progress?
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The Life Cycle of Ca2+ Ions in Dendritic Spines
Sabatini, B. L., Oertner, T. G., & Svoboda, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00573-1 · Cited by 745
Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses
Watt, A. J., van Rossum, M. C. W., MacLeod, K. M., Nelson, S. B., & Turrigiano, G. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81202-7 · Cited by 350
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The future of electronics based on memristive systems
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Spike Timing–Dependent Plasticity: A Hebbian Learning Rule
Caporale, N., & Dan, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125639 · Cited by 1,997
The Spike-Timing Dependence of Plasticity
Feldman, D. E. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.001 · Cited by 1,071
Spike Timing-Dependent Plasticity: From Synapse to Perception
Dan, Y., & Poo, M.-M. (2006) · Physiological Reviews · doi:10.1152/physrev.00030.2005 · Cited by 675
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649
Metadata
- Authors
- Shouval, H. Z., Bear, M. F., & Cooper, L. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-07-22
- Volume
- 99
- Issue
- 16
- Pages
- 10831-10836
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2154045630
- Cited by
- 607
- References
- 4
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Shouval, H. Z., Bear, M. F., & Cooper, L. N. (2002). A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.152343099
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