HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.

Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., & Roder, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8424 · Cited by 2,328 · see citing works

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

Yamagata, K., Oda, N., Kaisaki, P. J., Menzel, S., Furuta, H., Vaxillaire, M., Southam, L., Cox, R., Lathrop, M. G., Boriraj, V. V., et al. (1996) · Nature · doi:10.1038/384455a0 · Cited by 1,610 · see citing works

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

Rubinson, D. A., Dillon, C. P., Kwiatkowski, A. V., Sievers, C., Yang, L., Kopinja, J. E., Rooney, D. L., Zhang, M., Ihrig, M. M., McManus, M. T., et al. (2003) · Nature Genetics · doi:10.1038/ng1117 · Cited by 1,499 · see citing works

Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

Odom, D. T., Zizlsperger, N., Gordon, D. B., Bell, G. W., Rinaldi, N. J., Murray, H. L., Volkert, T. L., Schreiber, J., Rolfe, A., Gifford, D. K., et al. (2004) · Science · doi:10.1126/science.1089769 · Cited by 1,312 · see citing works

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

Si-Tayeb, K., Noto, F. K., Nagaoka, M., Li, J., Battle, M. A., Duris, C., North, P. E., Dalton, S., & Duncan, S. A. (2010) · Hepatology · doi:10.1002/hep.23354 · Cited by 1,282 · see citing works

Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency

Anokye‐Danso, F., Trivedi, C. M., Juhr, D., Gupta, M., Cui, Z., Tian, Y., Zhang, Y., Yang, W., Gruber, P. J., Epstein, J. A., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.03.001 · Cited by 1,206 · see citing works

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107 · see citing works

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

Yamagata, K., Furuta, H., Oda, N., Kaisaki, P. J., Menzel, S., Cox, N. J., Fajans, S. S., Signorini, S. G., Stoffel, M., & Bell, G. I. (1996) · Nature · doi:10.1038/384458a0 · Cited by 975 · see citing works

Organogenesis and development of the liver

Si-Tayeb, K., Lemaigre, F. P., & Duncan, S. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.011 · Cited by 800 · see citing works

iPS cells produce viable mice through tetraploid complementation

Zhao, X., Li, W., Lv, Z., Liu, L., Tong, M., Hai, T., Hao, J., Guo, C., Ma, Q., Wang, L., et al. (2009) · Nature · doi:10.1038/nature08267 · Cited by 778 · see citing works

Directed differentiation of human embryonic stem cells into functional hepatic cells†

Cai, J., Zhao, Y., Liu, Y., Ye, F., Song, Z., Qin, H., Meng, S., Chen, Y., Zhou, R., Song, X., et al. (2007) · Hepatology · doi:10.1002/hep.21582 · Cited by 628 · see citing works

Generation and Regeneration of Cells of the Liver and Pancreas

Zaret, K., & Grompe, M. (2008) · Science · doi:10.1126/science.1161431 · Cited by 601 · see citing works

Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis

Parviz, F., Matullo, C., Garrison, W. D., Savatski, L., Adamson, J. W., Ning, G., Kaestner, K. H., Rossi, J. M., Zaret, K. S., & Duncan, S. A. (2003) · Nature Genetics · doi:10.1038/ng1175 · Cited by 588 · see citing works

The initiation of liver development is dependent on Foxa transcription factors

Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature · doi:10.1038/nature03649 · Cited by 581 · see citing works

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.Preprint

Chen, W. S., Manova, K., Weinstein, D. C., Duncan, S. A., Plump, A. S., Prezioso, V. R., Bachvarova, R. F., & Darnell, J. E., Jr. (1994) · Genes & Development · doi:10.1101/gad.8.20.2466 · Cited by 553 · see citing works

Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes

Basma, H., Soto–Gutiérrez, A., Yannam, G. R., Liu, L., Ito, R., Yamamoto, T., Ellis, E. C. S., Carson, S. D., Sato, S., Chen, Y., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.047 · Cited by 509 · see citing works

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

Odom, D. T., Dowell, R. D., Jacobsen, E. S., Gordon, W., Danford, T. W., MacIsaac, K. D., Rolfe, P. A., Conboy, C. M., Gifford, D. K., & Fraenkel, E. (2007) · Nature Genetics · doi:10.1038/ng2047 · Cited by 506 · see citing works

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

(2000) · PubMed Central · Cited by 489 · see citing works

iPS cells can support full-term development of tetraploid blastocyst-complemented embryos.

Kang, L., Wang, J., Zhang, Y., Kou, Z.-H., & Gao, S.-R. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.07.001 · Cited by 488 · see citing works

Adult mice generated from induced pluripotent stem cells

Boland, M. J., Hazen, J. L., Nazor, K. L., Rodriguez, A. R., Gifford, W. D., Martin, G., Kupriyanov, S., & Baldwin, K. (2009) · Nature · doi:10.1038/nature08310 · Cited by 479 · see citing works

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

Martı́nez-Barberá, J. P., Clements, M., Thomas, P. Q., Rodríguez, T. A., Meloy, D., Kioussis, D., & Beddington, R. S. P. (2000) · Development · doi:10.1242/dev.127.11.2433 · Cited by 474 · see citing works

Activin A Efficiently Specifies Definitive Endoderm from Human Embryonic Stem Cells Only When Phosphatidylinositol 3-Kinase Signaling Is Suppressed

McLean, A. B., D’Amour, K. A., Jones, K. L., Krishnamoorthy, M., Kulik, M. J., Reynolds, D. M., Sheppard, A. M., Liu, H., Xu, Y., Baetge, E. E., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0219 · Cited by 473 · see citing works

Mammalian hepatocyte differentiation requires the transcription factor HNF-4αPreprint

Li, J., Ning, G., & Duncan, S. A. (2000) · Genes & Development · doi:10.1101/gad.14.4.464 · Cited by 458 · see citing works

Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells

Agarwal, S., Holton, K., & Lanza, R. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1102 · Cited by 402 · see citing works

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.

Duncan, S. A., Manova, K., Chen, W. S., Hoodless, P. A., Weinstein, D. C., Bachvarova, R. F., & Darnell, J. E., Jr. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7598 · Cited by 366 · see citing works

NS21: Re-defined and modified supplement B27 for neuronal cultures

Chen, Y., Stevens, B., Chang, J., Milbrandt, J., Barres, B. A., & Hell, J. W. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.03.013 · Cited by 304 · see citing works

Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4−/− embryos

Duncan, S. A., Nagy, A., & Chan, W. (1997) · Development · doi:10.1242/dev.124.2.279 · Cited by 291 · see citing works

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

Bort, R., Signore, M., Tremblay, K. D., Martı́nez-Barberá, J. P., & Zaret, K. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.006 · Cited by 285 · see citing works

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

Kyrmizi, I., Hatzis, P., Katrakili, N., Tronche, F., Gonzalez, F. J., & Talianidis, I. (2006) · Genes & Development · doi:10.1101/gad.390906 · Cited by 285 · see citing works

<i>Hex</i> homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

Bort, R., Martinez-Barbera, J. P., Beddington, R. S. P., & Zaret, K. S. (2004) · Development · doi:10.1242/dev.00965 · Cited by 267 · see citing works

Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies

Lemaigre, F. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.035 · Cited by 263 · see citing works

Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues

Ge, X., Yamamoto, S., Tsutsumi, S., Midorikawa, Y., Ihara, S., Wang, S. M., & Aburatani, H. (2005) · Genomics · doi:10.1016/j.ygeno.2005.04.008 · Cited by 248 · see citing works

Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

Battle, M. A., Konopka, G., Parviz, F., Gaggl, A. L., Yang, C., Sladek, F. M., & Duncan, S. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600246103 · Cited by 246 · see citing works

Development of the mammalian liver and ventral pancreas is dependent on GATA4

Watt, A. J., Zhao, R., Li, J., & Duncan, S. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-37 · Cited by 206 · see citing works

Culture of human pluripotent stem cells using completely defined conditions on a recombinant E-cadherin substratum

Nagaoka, M., Si‐Tayeb, K., Akaike, T., & Duncan, S. A. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-60 · Cited by 192 · see citing works

Homeobox Gene Hex Is Essential for Onset of Mouse Embryonic Liver Development and Differentiation of the Monocyte Lineage

Keng, V. W., Yagi, H., Ikawa, M., Nagano, T., Myint, Z. W., Yamada, K., Tanaka, T., Sato, A., Muramatsu, I., Okabe, M., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3548 · Cited by 183 · see citing works

Integrated Approach for the Identification of Human Hepatocyte Nuclear Factor 4α Target Genes Using Protein Binding Microarrays

Bolotin, E., Liao, H., Ta, T. C., Yang, C., Hwang‐Verslues, W. W., Evans, J. R., Jiang, T., & Sladek, F. M. (2009) · Hepatology · doi:10.1002/hep.23357 · Cited by 173 · see citing works

Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis

Taraviras, S. L., Monaghan, A. P., Schütz, G., & Kelsey, G. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90017-5 · Cited by 166 · see citing works

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing <i>p19ARF</i> expression

Suzuki, A., Sekiya, S., Büscher, D., Izpisúa Belmonte, J. C., & Taniguchi, H. (2008) · Development · doi:10.1242/dev.016634 · Cited by 136 · cited 1× · see citing works

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation†

Lüdtke, T. H. ‐., Christoffels, V. M., Petry, M., & Kispert, A. (2009) · Hepatology · doi:10.1002/hep.22700 · Cited by 117 · cited 3× · see citing works

Differentiation of mouse and human embryonic stem cells into hepatic lineages

Shiraki, N., Umeda, K., Sakashita, N., Takeya, M., Kume, K., & Kume, S. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01201.x · Cited by 112 · see citing works

Crucial role of vHNF1 in vertebrate hepatic specification

Lokmane, L., Haumaître, C., García-Villalba, P., Anselme, I., Schneider-Maunoury, S., & Cereghini, S. (2008) · Development · doi:10.1242/dev.023010 · Cited by 106 · see citing works

HNF4 and HNF1 as well as a panel of hepatic functions are extinguished and reexpressed in parallel in chromosomally reduced rat hepatoma-human fibroblast hybrids.

Griffo, G., Hamon-Benais, C., Angrand, P., Fox, M., West, L. F., Lecoq, O., Povey, S., Cassio, D., & Weiss, M. C. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.4.887 · Cited by 71 · see citing works

Serum-Free Media for Neural Cell Cultures: Adult and Embryonic

Price, P. J., & Brewer, G. J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-207-4:255 · Cited by 55 · see citing works

Junctional Adhesion Molecule-A Is Critical for the Formation of Pseudocanaliculi and Modulates E-cadherin Expression in Hepatic Cells

Konopka, G., Tekiela, J., Iverson, M., Wells, C. W., & Duncan, S. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703592200 · Cited by 51 · see citing works

the Homeobox Gene Hex Regulates Hepatocyte Differentiation From Embryonic Stem Cell–Derived Endoderm

Kubo, A., Kim, Y. H., Irion, S., Kasuda, S., Takeuchi, M., Ohashi, K., Iwano, M., Dohi, Y., Saito, Y., Snodgrass, R., et al. (2009) · Hepatology · doi:10.1002/hep.23293 · Cited by 43 · see citing works

Isolation and Transcriptional Profiling of Purified Hepatic Cells Derived from Human Embryonic Stem Cells

Chiao, E. T., Elazar, M., Xing, Y., Xiong, A., Kmet, M., Millan, M. T., Glenn, J. S., Wong, W. H., & Baker, J. C. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0964 · Cited by 42 · see citing works

Relationships between Hematopoiesis and Hepatogenesis in the Midtrimester Fetal Liver Characterized by Dynamic Transcriptomic and Proteomic Profiles

Guo, Y., Zhang, X., Huang, J., Zeng, Y. J., Liu, W., Geng, C., Li, K. W., Yang, D. C., Wu, S., Wei, H., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007641 · Cited by 36 · see citing works

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

Ma, X., Qu, X., Zhu, W. Z., Li, Y.-S. J., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S. E., Zanella, F., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524510113 · Cited by 880 · see citing works

In vitro generation of human pluripotent stem cell derived lung organoids

Dye, B. R., Hill, D. R., Ferguson, M. A. H., Tsai, Y.-H., Nagy, M. S., Dyal, R., Wells, J. M., Mayhew, C. N., Nattiv, R., Klein, O. D., et al. (2015) · eLife · doi:10.7554/elife.05098 · Cited by 824 · see citing works

Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells

Gifford, C. A., Ziller, M. J., Gu, H., Trapnell, C., Donaghey, J., Tsankov, A., Shalek, A. K., Kelley, D. R., Shishkin, A. A., Issner, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.037 · Cited by 435 · see citing works

Orchestrating liver development

Gordillo, M., Evans, T., & Gouon-Evans, V. (2015) · Development · doi:10.1242/dev.114215 · Cited by 375 · see citing works

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

Baxter, M. A., Withey, S., Harrison, S. P., Segeritz, C., Zhang, F., Atkinson-Dell, R., Rowe, C., Gerrard, D. T., Sison-Young, R. L. C., Jenkins, R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.016 · Cited by 353 · see citing works

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology*

Zachos, N., Kovbasnjuk, O., Foulke-Abel, J. D., In, J. G., Blutt, S., de Jonge, H. D., Estes, M., & Donowitz, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.635995 · Cited by 261 · see citing works

Transposable elements are the primary source of novelty in primate gene regulationPreprint

Trizzino, M., Park, Y., Beltrame, M. H., Aracena, K. A., Mika, K. M., Çalışkan, M., Perry, G. H., Lynch, V. J., & Brown, C. D. (2017) · Genome Research · doi:10.1101/gr.218149.116 · Cited by 273 · see citing works

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems

Shlomai, A., Schwartz, R. E., Ramanan, V., Bhatta, A., de Jong, Y. P., Bhatia, S. N., & Rice, C. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412631111 · Cited by 258 · see citing works

The molecular functions of hepatocyte nuclear factors – In and beyond the liver

Lau, H. H., Ng, N. H. J., Loo, L. S. W., Jasmen, J. B., & Teo, A. K. K. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.026 · Cited by 250 · see citing works

How to make an intestine

Wells, J. M., & Spence, J. (2014) · Development · doi:10.1242/dev.097386 · Cited by 168 · see citing works

JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia

Cayo, M. A., Cai, J., DeLaForest, A., Noto, F. K., Nagaoka, M., Clark, B. S., Collery, R. F., Si‐Tayeb, K., & Duncan, S. A. (2012) · Hepatology · doi:10.1002/hep.25871 · Cited by 148 · see citing works

Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model

Carpentier, A., Tesfaye, A., Chu, V., Nimgaonkar, I., Zhang, F., Lee, S. B., Thorgeirsson, S. S., Feinstone, S. M., & Liang, T. J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75456 · Cited by 146 · see citing works

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

Zhu, P., Wang, Y., Du, Y., He, L., Huang, G., Zhang, G., Yan, X., & Fan, Z. (2015) · Nature Communications · doi:10.1038/ncomms8122 · Cited by 141 · see citing works

Mapping gene regulatory circuitry of Pax6 during neurogenesis

Thakurela, S., Tiwari, N., Schick, S., Garding, A., Ivánek, R., Berninger, B., & Tiwari, V. K. (2016) · Cell Discovery · doi:10.1038/celldisc.2015.45 · Cited by 131 · see citing works

Bipotent transitional liver progenitor cells contribute to liver regeneration

Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01335-9 · Cited by 138 · see citing works

Identification of a functional antioxidant response element at the HIF1A locus

Lacher, S. E., Levings, D. C., Freeman, S., & Slattery, M. G. (2018) · Redox Biology · doi:10.1016/j.redox.2018.08.014 · Cited by 117 · see citing works

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci

Trynka, G., Westra, H.-J., Slowikowski, K., Hu, X., Xu, H., Stranger, B. E., Klein, R. J., Han, B., & Raychaudhuri, S. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.05.016 · Cited by 114 · see citing works

Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies

Yu, Y., Liu, H., Ikeda, Y., Amiot, B. P., Rinaldo, P., Duncan, S. A., & Nyberg, S. L. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.06.004 · Cited by 111 · see citing works

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction

Beggs, K. M., McGreal, S. R., McCarthy, A., Gunewardena, S., Lampe, J. N., Lau, C., & Apte, U. M. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.05.001 · Cited by 105 · see citing works

Stem cell-derived polarized hepatocytes

Thi, V. L. D., Wu, X., Belote, R. L., Andréo, U., Takacs, C. N., Fernandez, J., Vale-Silva, L. A., Prallet, S., Decker, C. C., Fu, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15337-2 · Cited by 100 · see citing works

Overexpression of miR‐122 promotes the hepatic differentiation and maturation of mouse ESCs through a miR‐122/FoxA1/HNF4a‐positive feedback loop

Deng, X., Qiu, R., Wu, Y., Li, Z., Xie, P., Zhang, J., Zhou, J., Zeng, L., Tang, J., Maharjan, A., et al. (2013) · Liver International · doi:10.1111/liv.12239 · Cited by 92 · see citing works

Taiji: System-level identification of key transcription factors reveals transcriptional waves in mouse embryonic development

Zhang, K., Wang, M., Zhao, Y., & Wang, W. (2019) · Science Advances · doi:10.1126/sciadv.aav3262 · Cited by 82 · see citing works

Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment

Kim, H., Im, I., Jeon, J. S., Kang, E.-H., Lee, H., Jo, S., Kim, J., Woo, D., Choi, Y. J., Kim, H. J., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121575 · Cited by 82 · see citing works

Hormonal Regulation of Liver Cytochrome P450 Enzymes

Waxman, D. J., & Chang, T. K. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-12108-6_11 · Cited by 78 · see citing works

Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications

Yiangou, L., Ross, A., Goh, K. J., & Vallier, L. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.03.016 · Cited by 78 · see citing works

Insulin and igfs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT pathway

Magner, N. L., Jung, Y., Wu, J., Nolta, J. A., Zern, M. Α., & Zhou, P. (2013) · Stem Cells · doi:10.1002/stem.1478 · Cited by 77 · see citing works

Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver

Thakur, A., Wong, J. C. H., Wang, E. Y., Lotto, J., Kim, D., Cheng, J., Mingay, M., Cullum, R., Moudgil, V., Ahmed, N., et al. (2019) · Hepatology · doi:10.1002/hep.30631 · Cited by 75 · see citing works

Pan-Genotype Hepatitis E Virus Replication in Stem Cell–Derived Hepatocellular Systems

Wu, X., Thi, V. L. D., Liu, P., Takacs, C. N., Xiang, K., Andrus, L., Gouttenoire, J., Moradpour, D., & Rice, C. M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.10.041 · Cited by 72 · see citing works

Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells

Peters, D. T., Henderson, C. A., Warren, C. R., Friesen, M., Xia, F., Becker, C. E., Musunuru, K., & Cowan, C. A. (2016) · Development · doi:10.1242/dev.132209 · Cited by 68 · see citing works

Human Induced Pluripotent Stem Cells in Hepatology

Gerbal‐Chaloin, S., Funakoshi, N., Caillaud, A., Gondeau, C., Champon, B., & Si‐Tayeb, K. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.09.026 · Cited by 64 · see citing works

GATA6 is essential for endoderm formation from human pluripotent stem cells

Fisher, J. B., Pulakanti, K., Rao, S., & Duncan, S. A. (2017) · Biology Open · doi:10.1242/bio.026120 · Cited by 62 · see citing works

Limited oxygen in standard cell culture alters metabolism and function of differentiated cells

Tan, J., Virtue, S., Norris, D. M., Conway, O. J., Yang, M. H., Bidault, G., Gribben, C., Lugtu, F., Kamzolas, I., Krycer, J. R., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00084-7 · Cited by 61 · see citing works

The Pharmacology of Regenerative Medicine

Christ, G. J., Saul, J. M., Furth, M. E., & Andersson, K. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007393 · Cited by 61 · see citing works

A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets

Wijetunga, N. A., Pascual, M., Tozour, J. N., Delahaye, F., Alani, M. T., Adeyeye, M., Wolkoff, A. W., Verma, A. K., & Greally, J. M. (2016) · Oncogene · doi:10.1038/onc.2016.340 · Cited by 55 · see citing works

HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II

DeLaForest, A., Furio, F. D., Jing, R., Ludwig-Kubinski, A., Twaroski, K., Urick, A., Pulakanti, K., Rao, S., & Duncan, S. A. (2018) · Genes · doi:10.3390/genes10010021 · Cited by 56 · see citing works

Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

Pan, J., Silva, T. C., Gull, N., Yang, Q., Plummer, J., Chen, S., Daigo, K., Hamakubo, T., Gery, S., Ding, L., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0390 · Cited by 55 · see citing works

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Ng, N. H. J., Jasmen, J. B., Lim, C. S., Lau, H. H., Krishnan, V. G., Kadiwala, J., Kulkarni, R. N., Ræder, H., Vallier, L., Hoon, S., et al. (2019) · iScience · doi:10.1016/j.isci.2019.05.032 · Cited by 54 · see citing works

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision

Takayama, K., Kawabata, K., Nagamoto, Y., Inamura, M., Ohashi, K., Okuno, H., Yamaguchi, T., Tashiro, K., Sakurai, F., Hayakawa, T., et al. (2013) · Development · doi:10.1242/dev.103168 · Cited by 54 · see citing works

A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features

Sgodda, M., Dai, Z., Zweigerdt, R., Sharma, A. D., Ott, M., & Cantz, T. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0023 · Cited by 53 · see citing works

FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1Preprint

Twaroski, K., Mallanna, S. K., Jing, R., Furio, F. D., Urick, A., & Duncan, S. A. (2015) · Genes & Development · doi:10.1101/gad.268961.115 · Cited by 52 · see citing works

Primate-specific ZNF808 is essential for pancreatic development in humans

Franco, E. D., Owens, N. D. L., Montaser, H., Wakeling, M. N., Saarimäki‐Vire, J., Triantou, A., Ibrahim, H., Balboa, D., Caswell, R. C., Jennings, R. E., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01565-x · Cited by 51 · see citing works

Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4α

Shi, X., Cheng, Q., Xu, L., Yan, J., Jiang, M., He, J., Xu, M., Stefanović-Račić, M., SIPULA, I. J., O'Doherty, R. M., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01094-13 · Cited by 51 · see citing works

Transcriptional Networks in Liver and Intestinal DevelopmentPreprint

Sheaffer, K. L., & Kaestner, K. H. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008284 · Cited by 50 · see citing works

Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia

Si‐Tayeb, K., Idriss, S., Champon, B., Caillaud, A., Pichelin, M., Arnaud, L., Lemarchand, P., May, C. L., Zibara, K., & Cariou, B. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.022277 · Cited by 50 · see citing works

A Gutsy Task: Generating Intestinal Tissue from Human Pluripotent Stem Cells

Finkbeiner, S. R., & Spence, J. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2620-2 · Cited by 53 · see citing works

GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition

Enane, F. O., Shuen, T. W. H., Gu, X., Ebrahem, Q., Przychodzen, B. P., Makishima, H., Bodo, J., Ng, J., Chee, C. L., Ba, R., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93488 · Cited by 48 · see citing works

TGFβ overrides HNF4α tumor suppressing activity through GSK3β inactivation: implication for hepatocellular carcinoma gene therapy

Cozzolino, A. M., Alonzi, T., Santangelo, L., Mancone, C., Conti, B., Steindler, C., Musone, M., Cicchini, C., Tripodi, M., & Marchetti, A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.023 · Cited by 48 · see citing works

HNF4α Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers

Ko, H. L., Zhuo, Z., & Ren, E. C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.033 · Cited by 48 · see citing works

Fetal liver development and implications for liver disease pathogenesis

Lotto, J., Stephan, T. L., & Hoodless, P. A. (2023) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-023-00775-2 · Cited by 47 · see citing works

Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation

Wu, N., Zhang, Y., Wang, H.-T., Li, D., Dai, H., Zhang, Q.-Q., Zhang, J., Ma, Y., Xia, Q., Bian, J., et al. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1177675 · Cited by 47 · see citing works

Gene regulatory networks in differentiation and direct reprogramming of hepatic cells

Gérard, C., Tys, J., & Lemaigre, F. P. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.12.003 · Cited by 46 · see citing works

Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells

Xue, D., Narisu, N., Taylor, D. L., Zhang, M., Grenko, C. M., Taylor, H. J., Yan, T., Tang, X., Sinha, N., Zhu, J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.09.013 · Cited by 46 · see citing works

Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes

Mallanna, S. K., Cayo, M. A., Twaroski, K., Gundry, R. L., & Duncan, S. A. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.07.016 · Cited by 44 · see citing works

HNF4α in Hepatocyte Health and Disease

Kotulkar, M., Robarts, D. R., & Apte, U. M. (2023) · Seminars in Liver Disease · doi:10.1055/a-2097-0660 · Cited by 43 · see citing works

Algorithm for cellular reprogramming

Ronquist, S., Patterson, G., Muir, L. A., Lindsly, S., Chen, H., Brown, M. A., Wicha, M. S., Bloch, A. M., Brockett, R. W., & Rajapakse, I. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712350114 · Cited by 40 · see citing works

Tissue Engineering: Future Perspectives

Furth, M., & Atala, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00006-9 · Cited by 22 · see citing works

Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment

Chaudhari, P., Tian, L., Deshmukh, A. P., & Jang, Y.-Y. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216657901 · Cited by 39 · see citing works

Mapping Gene Circuits Essential for Germ Layer Differentiation via Loss-of-Function Screens in Haploid Human Embryonic Stem Cells

Yilmaz, A., Braverman-Gross, C., Bialer-Tsypin, A., Peretz, M., & Benvenisty, N. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.06.023 · Cited by 39 · see citing works

Elucidating the Proximal Tubule HNF4A Gene Regulatory Network in Human Kidney Organoids

Yoshimura, Y., Muto, Y., Omachi, K., Miner, J. H., & Humphreys, B. D. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000197 · Cited by 38 · see citing works

Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors

Wei, J., Ran, G., Wang, X., Jiang, N., Liang, J., Lin, X., Ling, C., & Zhao, B. T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008616 · Cited by 36 · see citing works

The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases

Hansel, M., Dávila, J., Vosough, M., Gramignoli, R., Skvorak, K. J., Dorko, K., Marongiu, F., Blake, W., & Strom, S. C. (2016) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx1413s67 · Cited by 39 · see citing works

A small-molecule screen reveals that HSP90β promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover

Jing, R., Duncan, C. B., & Duncan, S. A. (2017) · Development · doi:10.1242/dev.146845 · Cited by 36 · see citing works

Protocol for directed differentiation of human pluripotent stem cells toward a hepatocyte fate

Cai, J. (2010) · StemBook · doi:10.3824/stembook.1.52.1 · Cited by 35 · see citing works

HNF4α-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma

Fekry, B., Ribas‐Latre, A., Baumgartner, C., Mohamed, A. M. T., Kolonin, M. G., Sladek, F. M., Younes, M., & Eckel‐Mahan, K. L. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1277 · Cited by 35 · see citing works

Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sitesPreprint

Savic, D., Roberts, B. S., Carleton, J. B., Partridge, E. C., White, M. A., Cohen, B. A., Cooper, G. M., Gertz, J., & Myers, R. (2015) · Genome Research · doi:10.1101/gr.191593.115 · Cited by 33 · see citing works

Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death

Sharma, S., Mishra, R., Walker, B. L., Deshmukh, S., Zampino, M., Patel, J. A., Anamalai, M., SIMPSON, D. L., Singh, I. S., Kaushal, S., et al. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-014-0536-1 · Cited by 33 · see citing works

A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms

Khazali, A. S., Clark, A. M., & Wells, A. H. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9735-3 · Cited by 31 · see citing works

Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer

Taniguchi, H., Fujimoto, A., Kono, H., Furuta, M., Fujita, M., & Nakagawa, H. (2018) · Oncotarget · doi:10.18632/oncotarget.25456 · Cited by 32 · see citing works

Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches

Varghese, D. S., Alawathugoda, T. T., & Ansari, S. A. (2019) · Stem Cells International · doi:10.1155/2019/5968236 · Cited by 32 · see citing works

Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids

Kluiver, T. A., Lu, Y., Schubert, S. A., Kraaier, L. J., Ringnalda, F. C. A. S., Lijnzaad, P., DeMartino, J., Megchelenbrink, W., Amo-Addae, V., Eising, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52757-w · Cited by 31 · see citing works

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1

Tamminen, K., Balboa, D., Toivonen, S., Pakarinen, M., Wiener, Z., Alitalo, K., & Otonkoski, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134551 · Cited by 31 · see citing works

MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency

Tryndyak, V., Marrone, A. K., Latendresse, J. R., Muskhelishvili, L., Beland, F. A., & Pogribny, I. P. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.10.001 · Cited by 31 · see citing works

Mouse decellularised liver scaffold improves human embryonic and induced pluripotent stem cells differentiation into hepatocyte-like cells

Lorvellec, M., Scottoni, F., Crowley, C., Fiadeiro, R., Maghsoudlou, P., Pellegata, A. F., Mazzacuva, F., Gjinovci, A., Lyne, A.-M., Zulini, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189586 · Cited by 30 · see citing works

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associationsPreprint

Ramaker, R. C., Hardigan, A. A., Goh, S.-T., Partridge, E. C., Wold, B. J., Cooper, S. J., & Myers, R. (2020) · Genome Research · doi:10.1101/gr.260463.119 · Cited by 30 · see citing works

Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors

Kogiso, T., Nagahara, H., Otsuka, M., Shiratori, K., & Dowdy, S. F. (2013) · Hepatology International · doi:10.1007/s12072-013-9432-5 · Cited by 26 · see citing works

Transcription Factors and Medium Suitable for Initiating the Differentiation of Human‐Induced Pluripotent Stem Cells to the Hepatocyte Lineage

Tomizawa, M., Shinozaki, F., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., & Ishige, N. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25494 · Cited by 27 · see citing works

CEN‐tools: an integrative platform to identify the contexts of essential genes

Sharma, S., Dinçer, C., Weidemüller, P., Wright, G. J., & Petsalaki, E. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209698 · Cited by 25 · see citing works

miRNA‐548p suppresses hepatitis B virus X protein associated hepatocellular carcinoma by downregulating oncoprotein hepatitis B x‐interacting protein

Hu, X., Yan, X., Hu, Y., Huang, J., Cao, S., Ren, T., Tang, Y., Li, L., Zheng, L., & Wang, Q. (2015) · Hepatology Research · doi:10.1111/hepr.12618 · Cited by 25 · see citing works

Albumin gene targeting in human embryonic stem cells and induced pluripotent stem cells with helper-dependent adenoviral vector to monitor hepatic differentiation

Umeda, K., Suzuki, K., Yamazoe, T., Shiraki, N., Higuchi, Y., Tokieda, K., Kume, K., Mitani, K., & Kume, S. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.11.003 · Cited by 24 · see citing works

Let-7f microRNA negatively regulates hepatic differentiation of human adipose tissue-derived stem cells

Davoodian, N., Lotfi, A. S., Soleimani, M., Mola, S. J., & Arjmand, S. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0346-z · Cited by 24 · see citing works

Patterning of the hepato-pancreatobiliary boundary by BMP reveals heterogeneity within the murine liver bud

Palaria, A., Angelo, J. R., Guertin, T. M., Mager, J., & Tremblay, K. D. (2018) · Hepatology · doi:10.1002/hep.29769 · Cited by 24 · see citing works

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Toivonen, S., Malinen, M. M., Küblbeck, J., Petsalo, A., Urtti, A. O., Honkakoski, P., & Otonkoski, T. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0127 · Cited by 24 · see citing works

Liver Renewal: Detecting Misrepair and Optimizing Regeneration

Machado, M. V., & Diehl, A. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.009 · Cited by 24 · see citing works

Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells

Nagaoka, M., Kobayashi, M., Chie, K., Mallanna, S. K., & Duncan, S. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136350 · Cited by 23 · see citing works

The Use of Human Pluripotent Stem Cells for Modeling Liver Development and Disease

Heslop, J. A., & Duncan, S. A. (2018) · Hepatology · doi:10.1002/hep.30288 · Cited by 23 · see citing works

Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture

Freyer, N., Greuel, S., Knöspel, F., Strahl, N., Amini, L., Jacobs, F., Monshouwer, M., & Zeilinger, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081724 · Cited by 23 · see citing works

The importance of transporters and cell polarization for the evaluation of human stem cell-derived hepatic cells

Török, G., Erdei, Z., Lilienberg, J., Apáti, Á., & Homolya, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227751 · Cited by 23 · see citing works

Signalling pathways and transcriptional regulators orchestrating liver development and cancer

Campbell, S. A., Stephan, T. L., Lotto, J., Cullum, R., Drissler, S., & Hoodless, P. A. (2021) · Development · doi:10.1242/dev.199814 · Cited by 22 · see citing works

Visceral Endoderm Expression of Yin-Yang1 (YY1) Is Required for VEGFA Maintenance and Yolk Sac Development

Rhee, S., Guerrero-Zayas, M.-I., Wallingford, M. C., Ortíz-Pineda, P. A., Mager, J., & Tremblay, K. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058828 · Cited by 22 · see citing works

Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α

Chen, K.-T., Pernelle, K., Tsai, Y.-H., Wu, Y., Hsieh, J.-Y., Liao, K., Guguen‐Guillouzo, C., & Wang, H. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.025 · Cited by 21 · see citing works

Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease Modeling

Yuan, Y., Cotton, K., Samarasekera, D. N., & Khetani, S. R. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.01.013 · Cited by 21 · see citing works

Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α

Hu, X., Xie, P., Li, W., Li, Z., & Shan, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.026 · Cited by 21 · see citing works

Tissue-Engineered Bile Ducts for Disease Modeling and Therapy

Wang, Z., Faria, J., Penning, L. C., Masereeuw, R., & Spee, B. (2020) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2020.0283 · Cited by 21 · see citing works

Deregulated GATA6 modulates stem cell‐like properties and metabolic phenotype in hepatocellular carcinoma

Tan, H., Leung, C. O., Chan, K. K., Ho, D. W., Leung, M., Wong, C., Ng, I. O., & Lo, R. C. (2019) · International Journal of Cancer · doi:10.1002/ijc.32248 · Cited by 22 · see citing works

Balancing metabolism and regeneration in liver diseases through HNF4α targeting

Dender, C. V., Vandewalle, J., & Libert, C. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.04.003 · Cited by 20 · see citing works

Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling

Wang, W., Li, S., Liu, P., Sideras, K., van de Werken, H. J. G., van der Heide, M., Cao, W., Lavrijsen, M., Peppelenbosch, M. P., Bruno, M. J., et al. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0054 · Cited by 20 · see citing works

Characterization of genetic variants in the EGLN1/PHD2 gene identified in a European collection of patients with erythrocytosis

Delamare, M., Roy, A. L., Pacault, M., Schmitt, L., Garrec, C., Maaziz, N., Myllykoski, M., Rimbert, A., Karaghiannis, V., Aral, B., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.282913 · Cited by 21 · see citing works

A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells

Hurrell, T., Segeritz, C., Vallier, L., Lilley, K. S., & Cromarty, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-39400-1 · Cited by 20 · see citing works

Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells

Wang, A., & Sander, M. (2012) · Journal of molecular medicine · doi:10.1007/s00109-012-0923-y · Cited by 18 · see citing works

Exploring the role of HNF4α in hepatic differentiation from pluripotent stem cells

Wang, Y. (2019) · ERA

HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II

DeLaForest, A., Furio, F. D., Jing, R., Ludwig-Kubinski, A., Twaroski, K., Urick, A., Pulakanti, K., Rao, S., & Duncan, S. A. (2018) · Genes · doi:10.3390/genes10010021 · Cited by 56 · see citing works

HNF-4α determines hepatic differentiation of human mesenchymal stem cells from bone marrow

Chen, M.-L. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i40.5092 · Cited by 29 · see citing works

Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects

Zhao, D., Chen, S., Duo, S., Xiang, C., Jia, J., Guo, M., Lai, W., Lu, S., & Deng, H. (2012) · Cell Research · doi:10.1038/cr.2012.144 · Cited by 53 · see citing works

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

Wang, Y., Tatham, M. H., Schmidt‐Heck, W., Swann, C. J., Dolt, K. S., Meseguer-Ripolles, J., Lucendo‐Villarin, B., Kunath, T., Rudd, T. R., Smith, A. J. H., et al. (2019) · iScience · doi:10.1016/j.isci.2019.05.028 · Cited by 16 · see citing works