The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Tumor-associated fibroblasts predominantly come from local and not circulating precursors
Open accessAbstract
Significance: Fibroblasts constitute an important element of tumors and have received considerable attention in recent years due to their tumor-promoting and immunosuppressive properties. As a consequence, tumor-associated fibroblasts (TAFs) are considered an attractive target for cancer therapies. However, their origin remains controversial, with some evidence pointing at a local origin, whereas many publications suggest a significant contribution of progenitors from bone marrow. We found that TAFs derive almost exclusively from local sources. Therefore, therapeutic strategies to target fibroblasts must exploit local recruitment and the unique transcriptional and response patterns of fibroblasts from different sites.
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“The gradual nature of the transitions observed has given rise to the view that the majority of stromal fibroblasts initially originate from local fibroblasts that experience some form of tissue dysfunction31,32.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [32]
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Cites
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
The distribution of secondary growths in cancer of the breast.
Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 1×
“MSCs are radioresistant (43, 44), reside in multiple organs in perivascular locations (45), and have migratory capability (45).”
BackgroundOlive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,472
Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195
Klinge, U., Park, J.-K., & Klosterhalfen, B. (2013) · Pathobiology · doi:10.1159/000348446 · Cited by 1,791
A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse
Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591
Research works printed but not linked: 2
- A Maximov, Culture of blood leukocytes. From lymphocytes and monocytes to connective tissue. Arch Exp Zellforsch 5, 169–268 (1928).
- DH Cormack Essential Histology (Lippincott Williams & Wilkins, 2nd Ed, Philadelphia, 2001).
Cited by
Sorted by citations
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059
A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863
Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265
Clinical and therapeutic relevance of cancer-associated fibroblasts
Chen, Y., McAndrews, K. M., & Kalluri, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00546-5 · Cited by 1,230
Metadata
- Authors
- Arina, A., Idel, C., Hyjek, E. M., Alegre, M.-L., Wang, Y., Bindokas, V. P., Weichselbaum, R. R., & Schreiber, H.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Arina, Ainhoa
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-06-17
- Volume
- 113
- Issue
- 27
- Pages
- 7551-7556
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4941507
- OpenAlex
- W2442704894
- Cited by
- 238
- References
- 69
- Citations by year
- 2026: 20 · 2025: 38 · 2024: 35 · 2023: 37 · 2022: 26 · 2021: 29 · 2020: 21 · 2019: 12 · 2018: 12 · 2017: 7 · 2016: 1
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | National Institutes of Health (P01-CA97296, R01-CA22677, R01-CA37516)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- cancer-associated fibroblasts, tumor stroma, fibroblast origin, type I collagen, parabiosis, bone marrow chimeras, skin grafting, tumor microenvironment, collagen deposition
- MeSH terms
- Cancer-Associated Fibroblasts, Actins, Animals, Mice, Inbred C57BL, Neoplasms, Experimental, Mice, Knockout, Collagen Type I, Cell Line, Tumor, Green Fluorescent Proteins
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