The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
Open accessAbstract
Significance: In the United States, the most common cause of allergic contact dermatitis (ACD) is contact with poison ivy. Severe itch and skin inflammation are the major manifestations of poison ivy-induced ACD. In this study, we have established a critical role of IL-33/ST2 (interleukin 33/growth stimulation expressed gene 2) signaling in both itch and skin inflammation of poison ivy-induced ACD and revealed a previously unidentified interaction of IL-33/ST2 signaling with primary sensory neurons that may underlie the pruritic mechanisms of poison ivy-induced ACD. Blocking IL-33/ST2 signaling may represent a therapeutic approach to ameliorate itch and skin inflammation related to poison ivy dermatitis and, possibly, other chronic itch conditions in which IL-33/ST2 signaling may participate.
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Cites
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D. M., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 987
Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus
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Interleukin-33 in tissue homeostasis, injury, and inflammation
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Early immune events in the induction of allergic contact dermatitis
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Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation
Talbot, S., Abdulnour, R.-E. E., Burkett, P. R., Lee, S., Cronin, S. J. F., Pascal, M. A., Laedermann, C., Foster, S. L., Tran, J. V., Lai, N., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.007 · Cited by 452
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Behavioral differentiation between itch and pain in mouse
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TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
Liu, B., Fan, L., Balakrishna, S., Sui, A., Morris, J. B., & Jordt, S.-E. (2013) · Pain · doi:10.1016/j.pain.2013.06.043 · Cited by 319
Self-citationDhingra, N., Shemer, A., Correa da Rosa, J., Rozenblit, M., Fuentes-Duculan, J., Gittler, J. K., Finney, R., Czarnowicki, T., Zheng, X., Xu, H., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.009 · Cited by 305
Cited by
Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
Oetjen, L. K., Mack, M. R., Feng, J., Whelan, T. M., Niu, H., Guo, C. J., Chen, S., Trier, A. M., Xu, A. Z., Tripathi, S. V., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.006 · Cited by 1,092
Astrocytes in chronic pain and itch
Ji, R.-R., Donnelly, C. R., & Nedergaard, M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0218-1 · Cited by 538
Baral, P., Umans, B. D., Li, L., Wallrapp, A., Bist, M., Kirschbaum, T., Wei, Y., Zhou, Y., Kuchroo, V. K., Burkett, P. R., et al. (2018) · Nature Medicine · doi:10.1038/nm.4501 · Cited by 422
Meixiong, J., Anderson, M., Limjunyawong, N., Sabbagh, M. F., Hu, E., Mack, M. R., Oetjen, L. K., Wang, F., Kim, B. S., & Dong, X. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.013 · Cited by 369
Metadata
- Authors
- Liu, B., Tai, Y., Achanta, S., Kaelberer, M. M., Caceres, A. I., Shao, X., Fang, J., & Jordt, S.-E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-11-07
- Volume
- 113
- Issue
- 47
- Pages
- E7572-E7579
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2549478702
- Cited by
- 323
- References
- 36
- FWCI
- 22.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy. https://app.cochat.ai/papers/10.1073/pnas.1606608113
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- Liu, B., Tai, Y., Achanta, S., Kaelberer, M. M., Caceres, A. I., Shao, X., Fang, J., & Jordt, S.-E. (2016). IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1606608113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
