The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice
Abstract
Significance: Direct reprogramming of nonneuronal cells into induced neuronal (iN) cells has been of great interest for its potential applications in neurological disease modeling. Although this approach is well-established using cells from embryonic and neonatal animals, its applicability for cells from adult and aged animals has remained unexplored. This study demonstrates that iN cells can be efficiently generated from aging animals, but that age-dependent roadblocks which depend on the transcription factor FoxO3 affect the reprogramming efficiency and functional maturation of iN cell properties. Eliminating these roadblocks may be useful for modeling age-related neurological disorders using iN cells.
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Partial de-differentiation is necessary for rejuvenation to occur.
“emphasizing the necessity of partial de-differentiation for rejuvenation (Box 1) to occur [22][23][24][25] .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [22]
The Developmental Stage section reports direct conversion of fibroblasts from aged mice into neurons, and the Discussion addresses how age affects reprogramming. Neither section addresses rejuvenation or establishes that partial de-differentiation is necessary for it (searched: partial de-differentiation, rejuvenation, and age-associated characteristics). (LLM, conf=0.77)
Experimental — accuracy not yet measuredAging-associated DNA methylation patterns and biomarkers persisted when cells were transdifferentiated to different cell types.
“Conversely, other works have shown that aging-associated DNA methylation patterns and biomarkers persisted when cells were transdifferentiated (Box 1) to different cell types, emphasizing the necessity of partial de-differentiation for rejuvenation (Box 1) to occur [22][23][24][25] .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [22]
The section “Several Aging-Associated Cellular Features Correlate with Reduced Reprogrammability” reports senescence markers in donor fibroblasts, while “Developmental Stage but Not Adult Aging Impairs iN Cell Reprogramming” reports their conversion into neurons. Neither section establishes that aging biomarkers persisted after conversion. Searches for DNA methylation patterns, epigenetic age, and retained markers found no passage addressing that claim. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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Citations
Cites
Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J. R., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.001 · Cited by 765
Senescence impairs successful reprogramming to pluripotent stem cells
Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., et al. (2009) · Genes & Development · doi:10.1101/gad.1811609 · Cited by 642
Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts
Victor, M. B., Richner, M., Hermanstyne, T. O., Ransdell, J. L., Sobieski, C., Deng, P.-Y., Klyachko, V. A., Nerbonne, J. M., & Yoo, A. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.016 · Cited by 295
FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis
Webb, A. E., Pollina, E. A., Vierbuchen, T., Urbán, N., Ucar, D., Leeman, D. S., Martynoga, B., Sewak, M., Rando, T. A., Guillemot, F., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.035 · Cited by 164
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Cited by
Sorted by citations
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Cipriano, A., Moqri, M., Maybury-Lewis, S. Y., Rogers-Hammond, R., de Jong, T. A., Parker, A., Rasouli, S., Schöler, H. R., Sinclair, D. A., & Sebastiano, V. (2023) · Nature Aging · doi:10.1038/s43587-023-00539-2 · Cited by 66
Metadata
- Authors
- Ahlenius, H., Chanda, S., Webb, A. E., Yousif, I., Karmazin, J., Prusiner, S. B., Brunet, A., Südhof, T. C., & Wernig, M.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-07-11
- Volume
- 113
- Issue
- 30
- Pages
- 8514-8519
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 26
- References
- 4
- Language
- en
- Funders
- HHS | NIH | National Institute on Aging (AG010770-18A1)
- HHS | NIH | National Institute of Mental Health (R01MH092931)
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