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Neurotrophins are required for nerve growth during development

Tucker, Kerry Lee, Meyer, Michael, Barde, Yves-Alain·2001·Nature Neuroscience
DOI 10.1038/82868
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Abstract

Although the requirement of neurotrophins for the prevention of cell death in the peripheral nervous system is well established, their physiological involvement in nerve growth is still unclear. To address this question, we generated a mouse that expresses the green fluorescent protein in post-mitotic neurons, allowing the repeated visualization of all motor and sensory axons during development. We imaged the growth of these axons into the limb bud of day 10.5 embryos. Sensory axons, but rarely motor axons, were targeted to ectopically placed beads containing any of the neurotrophins NGF, BDNF, NT-3 or NT-4/5. Conversely, a combination of function-blocking monoclonal antibodies to NGF, BDNF and NT-3 dramatically inhibited elongation of both sensory and motor axons in the limb bud, indicating that the growth of mixed nerves is dependent upon neurotrophins during development.

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  • Humanized tau models such as hTau feature age-dependent tau pathology, neuronal loss and memory deficits.

    “humanized tau models such as the hTau model comprising a P1-derived artificial chromosome (PAC) copy of the human MAPT gene locus in a murine Mapt KO background (Duff, Knight et al. 2000, Tucker, Meyer et al. 2001, Andorfer, Kress et al. 2003) also feature age-dependent tau pathology, neuronal loss and memory deficits (Andorfer, Kress et al. 2003, Andorfer, Acker et al. 2005, Polydoro, Acker et al”

    From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Tucker, Meyer et al. 2001

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Cited by

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Authors
Tucker, K. L., Meyer, M., & Barde, Y.-A.
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2001-01
Volume
4
Issue
1
Pages
29-37
ISSN
  • 1097-6256
  • 1546-1726
DOI
10.1038/82868
Cited by
477
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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