Cited by 62

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A pathway of targeted autophagy is induced by DNA damage in budding yeast

Eapen, Vinay V., Waterman, David P., Bernard, Amélie, Schiffmann, Nathan, Sayas, Enrich, Kamber, Roarke, Lemos, Brenda, Memisoglu, Gonen, Ang, Jessie, Mazella, Allison, Chuartzman, Silvia G., Loewith, Robbie J., Schuldiner, Maya, Denic, Vladimir, Klionsky, Daniel J., Haber, James E.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1614364114

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Abstract

Significance: The DNA damage response (DDR) is a well-orchestrated and tightly regulated process. The DDR pathway does not act in isolation; indeed, evidence of cross-talk between the DDR and numerous signaling pathways affecting cytoskeletal integrity, nutrient sensing, and autophagy has been demonstrated. In this paper, we report that the DDR induces a distinct pathway of autophagy: genotoxin-induced targeted autophagy (GTA). GTA requires the action of the checkpoint kinases Mec1/ATR, Tel1/ATM, and Rad53/CHEK2. Rad53 mediates the transcriptional up-regulation of autophagy genes via negative regulation of the repressor Rph1/KDM4. GTA requires components of the selective autophagy machinery and is distinct from canonical autophagy pathways. A genome-wide screen for GTA modulators identifies genes required for genotoxin-induced autophagy and starvation-induced autophagy.

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Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 2×
“To monitor autophagy after DNA damage, we used the wellestablished GFP-Atg8 processing assay (25, 26).”
MethodSelf-citation
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138
DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell · doi:10.1016/j.cell.2006.05.034 · Cited by 1,380
Regulation of autophagy by cytoplasmic p53
Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1730 · Cited by 1,132
Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile
Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870
Self-citation
Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms
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Mitophagy in Yeast Occurs through a Selective Mechanism
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Sorted by citations

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
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Autophagy role(s) in response to oncogenes and DNA replication stress
Vanzo, R., Bartkova, J., Merchut-Maya, J. M., Hall, A., Bouchal, J., Dyrskjøt, L., Frankel, L. B., Gorgoulis, V., Maya-Mendoza, A., Jäättelä, M., et al. (2020) · Cell Death & Differentiation · doi:10.1038/s41418-019-0403-9 · Cited by 79

Authors: Eapen, V. V., Waterman, D. P., Bernard, A., Schiffmann, N., Sayas, E., Kamber, R., Lemos, B., Memisoglu, G., Ang, J., Mazella, A., Chuartzman, S. G., Loewith, R. J., Schuldiner, M., Denic, V., Klionsky, D. J., & Haber, J. E.
Affiliations: Department of Biology, Brandeis University, Waltham, MA 02454;
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109;
Department of Molecular Genetics, Weizmann Institute of Sciences, Rehovot, Israel 7610001;
Department of Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland;
Molecular and Cell Biology, Harvard University, Cambridge, MA 02138
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-02-02
Volume: 114
Issue: 7
ISSN: 0027-8424
1091-6490
DOI: 10.1073/pnas.1614364114
Cited by: 62
References: 7
Language: en
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Funders: HHS | National Institutes of Health (GM61766, GM053396, T32 GM007122)
HHS | NIH | National Institute of General Medical Sciences (GM20056)
United States-Israel Binational Science Foundation (2013101)

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A pathway of targeted autophagy is induced by DNA damage in budding yeast

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