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Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2
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“The reasons for this difference in rapamycin sensitivity is structural; the mTOR interacting protein RICTOR, which is present in mTORC2 but not mTORC1, masks the rapamycin-interacting domain of mTOR29–31.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [30]
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Self-citationmTOR kinase structure, mechanism and regulation
Yang, H., Rudge, D. G., Koos, J. D., Vaidialingam, B., Yang, H. J., & Pavletich, N. P. (2013) · Nature · doi:10.1038/nature12122 · Cited by 1,075
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Phosphorylation of Akt at the C-terminal tail triggers Akt Activation
Liu, P., Wang, Z., & Wei, W. (2014) · Cell Cycle · doi:10.4161/cc.29584 · Cited by 49
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Metadata
- Authors
- Gaubitz, C., Oliveira, T. M., Prouteau, M., Leitner, A., Karuppasamy, M., Konstantinidou, G., Rispal, D., Eltschinger, S., Robinson, G. C., Thore, S., Aebersold, R., Schaffitzel, C., & Loewith, R.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 58
- Issue
- 6
- Pages
- 977-988
- ISSN
- 1097-2765
- Cited by
- 142
- References
- 4
- Language
- en
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- Gaubitz, C., Oliveira, T. M., Prouteau, M., Leitner, A., Karuppasamy, M., Konstantinidou, G., Rispal, D., Eltschinger, S., Robinson, G. C., Thore, S., Aebersold, R., Schaffitzel, C., & Loewith, R. (2015). Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Molecular Cell. https://doi.org/10.1016/j.molcel.2015.04.031