Cited by 142

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2

Gaubitz, Christl, Oliveira, Taiana M., Prouteau, Manoel, Leitner, Alexander, Karuppasamy, Manikandan, Konstantinidou, Georgia, Rispal, Delphine, Eltschinger, Sandra, Robinson, Graham C., Thore, Stéphane, Aebersold, Ruedi, Schaffitzel, Christiane, Loewith, Robbie·2015·Molecular Cell

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molcel.2015.04.031

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 4 references

Research works printed but not linked: 50

  1. Adami, 2007, Structure of TOR and its complex with KOG1, Mol. Cell, 27, 509, 10.1016/j.molcel.2007.05.040 · DOI
  2. Barbet, 1996, TOR controls translation initiation and early G1 progression in yeast, Mol. Biol. Cell, 7, 25, 10.1091/mbc.7.1.25 · DOI
  3. Berchtold, 2009, TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain, Mol. Biol. Cell, 20, 1565, 10.1091/mbc.E08-10-1001 · DOI
  4. Berchtold, 2012, Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis, Nat. Cell Biol., 14, 542, 10.1038/ncb2480 · DOI
  5. Brazil, 2001, Ten years of protein kinase B signalling: a hard Akt to follow, Trends Biochem. Sci., 26, 657, 10.1016/S0968-0004(01)01958-2 · DOI · Paper page
  6. Cafferkey, 1993, Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity, Mol. Cell. Biol., 13, 6012, 10.1128/MCB.13.10.6012 · DOI
  7. Cornu, 2013, mTOR in aging, metabolism, and cancer, Curr. Opin. Genet. Dev., 23, 53, 10.1016/j.gde.2012.12.005 · DOI
  8. de la Rosa-Trevín, 2013, Xmipp 3.0: an improved software suite for image processing in electron microscopy, J. Struct. Biol., 184, 321, 10.1016/j.jsb.2013.09.015 · DOI
  9. Elad, 2008, Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections, J. Struct. Biol., 162, 108, 10.1016/j.jsb.2007.11.007 · DOI
  10. Fadri, 2005, The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2, Mol. Biol. Cell, 16, 1883, 10.1091/mbc.E04-07-0564 · DOI
  11. Hara, 2002, Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action, Cell, 110, 177, 10.1016/S0092-8674(02)00833-4 · DOI
  12. Heitman, 1991, Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast, Science, 253, 905, 10.1126/science.1715094 · DOI
  13. Helliwell, 1994, TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast, Mol. Biol. Cell, 5, 105, 10.1091/mbc.5.1.105 · DOI
  14. Jacinto, 2004, Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive, Nat. Cell Biol., 6, 1122, 10.1038/ncb1183 · DOI
  15. Jain, 2014, Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown, Proc. Natl. Acad. Sci. USA, 111, 17833, 10.1073/pnas.1419425111 · DOI
  16. Keith, 1995, PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints, Science, 270, 50, 10.1126/science.270.5233.50 · DOI
  17. Kim, 2002, mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell, 110, 163, 10.1016/S0092-8674(02)00808-5 · DOI
  18. Kliegman, 2013, Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae, Cell Rep., 5, 1725, 10.1016/j.celrep.2013.11.040 · DOI
  19. Kunz, 1993, Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression, Cell, 73, 585, 10.1016/0092-8674(93)90144-F · DOI
  20. Laplante, 2012, mTOR signaling in growth control and disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017 · DOI · Paper page
  21. Leitner, 2014, Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline, Nat. Protoc., 9, 120, 10.1038/nprot.2013.168 · DOI
  22. Lempiäinen, 2009, Emerging common themes in regulation of PIKKs and PI3Ks, EMBO J., 28, 3067, 10.1038/emboj.2009.281 · DOI
  23. Liao, 2012, Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae, J. Biol. Chem., 287, 6089, 10.1074/jbc.M111.303701 · DOI
  24. Liu, 2013, Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis, Nat. Cell Biol., 15, 1340, 10.1038/ncb2860 · DOI
  25. Liu, 2014, Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus, Nature, 508, 541, 10.1038/nature13079 · DOI
  26. Loewith, 2011, Target of rapamycin (TOR) in nutrient signaling and growth control, Genetics, 189, 1177, 10.1534/genetics.111.133363 · DOI
  27. Lu, 2011, mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel, J. Biol. Chem., 286, 30647, 10.1074/jbc.M111.257592 · DOI
  28. Ludtke, 2010, 3-D structures of macromolecules using single-particle analysis in EMAN, Methods Mol. Biol., 673, 157, 10.1007/978-1-60761-842-3_9 · DOI
  29. Merkley, 2014, Distance restraints from crosslinking mass spectrometry: Mining a molecular dynamics simulation database to evaluate lysine-lysine distances, Protein Sci., 23, 747, 10.1002/pro.2458 · DOI
  30. Niles, 2012, Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2, Proc. Natl. Acad. Sci. USA, 109, 1536, 10.1073/pnas.1117563109 · DOI
  31. Pan, 2012, Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 68, 386, 10.1107/S1744309112007178 · DOI
  32. Pracheil, 2012, TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae, Genetics, 190, 1325, 10.1534/genetics.111.138305 · DOI
  33. Roelants, 2011, Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae, Proc. Natl. Acad. Sci. USA, 108, 19222, 10.1073/pnas.1116948108 · DOI
  34. Rosenthal, 2003, Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy, J. Mol. Biol., 333, 721, 10.1016/j.jmb.2003.07.013 · DOI · Paper page
  35. Sarbassov, 2004, Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton, Curr. Biol., 14, 1296, 10.1016/j.cub.2004.06.054 · DOI · Paper page
  36. Scheres, 2012, RELION: implementation of a Bayesian approach to cryo-EM structure determination, J. Struct. Biol., 180, 519, 10.1016/j.jsb.2012.09.006 · DOI · Paper page
  37. Scheres, 2008, Image processing for electron microscopy single-particle analysis using XMIPP, Nat. Protoc., 3, 977, 10.1038/nprot.2008.62 · DOI
  38. Shimada, 2013, TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks, Mol. Cell, 51, 829, 10.1016/j.molcel.2013.08.019 · DOI
  39. Sibanda, 2010, Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats, Nature, 463, 118, 10.1038/nature08648 · DOI
  40. Sparks, 2010, Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy, Oncogene, 29, 3733, 10.1038/onc.2010.139 · DOI
  41. Tarassov, 2008, An in vivo map of the yeast protein interactome, Science, 320, 1465, 10.1126/science.1153878 · DOI
  42. Uetz, 2000, A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae, Nature, 403, 623, 10.1038/35001009 · DOI · Paper page
  43. Urban, 2007, Sch9 is a major target of TORC1 in Saccharomyces cerevisiae, Mol. Cell, 26, 663, 10.1016/j.molcel.2007.04.020 · DOI · Paper page
  44. van Heel, 1996, A new generation of the IMAGIC image processing system, J. Struct. Biol., 116, 17, 10.1006/jsbi.1996.0004 · DOI
  45. Voss, 2009, DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy, J. Struct. Biol., 166, 205, 10.1016/j.jsb.2009.01.004 · DOI
  46. Walzthoeni, 2012, False discovery rate estimation for cross-linked peptides identified by mass spectrometry, Nat. Methods, 9, 901, 10.1038/nmeth.2103 · DOI
  47. Wedaman, 2003, Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae, Mol. Biol. Cell, 14, 1204, 10.1091/mbc.E02-09-0609 · DOI
  48. Wullschleger, 2005, Molecular organization of target of rapamycin complex 2, J. Biol. Chem., 280, 30697, 10.1074/jbc.M505553200 · DOI
  49. Yip, 2010, Structure of the human mTOR complex I and its implications for rapamycin inhibition, Mol. Cell, 38, 768, 10.1016/j.molcel.2010.05.017 · DOI · Paper page
  50. Zinzalla, 2011, Activation of mTORC2 by association with the ribosome, Cell, 144, 757, 10.1016/j.cell.2011.02.014 · DOI

Cited by

Sorted by citations

See all 142

Metadata

Authors
Gaubitz, C., Oliveira, T. M., Prouteau, M., Leitner, A., Karuppasamy, M., Konstantinidou, G., Rispal, D., Eltschinger, S., Robinson, G. C., Thore, S., Aebersold, R., Schaffitzel, C., & Loewith, R.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2015-06
Volume
58
Issue
6
Pages
977-988
ISSN
1097-2765
Cited by
142
References
4
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. https://app.cochat.ai/papers/10.1016/j.molcel.2015.04.031
The paper
Gaubitz, C., Oliveira, T. M., Prouteau, M., Leitner, A., Karuppasamy, M., Konstantinidou, G., Rispal, D., Eltschinger, S., Robinson, G. C., Thore, S., Aebersold, R., Schaffitzel, C., & Loewith, R. (2015). Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Molecular Cell. https://doi.org/10.1016/j.molcel.2015.04.031