Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603

Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.

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Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette

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Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

Mei, F., Fancy, S. P. J., Shen, Y. A., Niu, J., Zhao, C., Presley, B., Miao, E., Lee, S., Mayoral, S. R., Redmond, S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3618 · Cited by 595

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

Wang, S., Bates, J., Li, X., Schanz, S., Chandler-Militello, D., Levine, C., Maherali, N., Studer, L., Hochedlinger, K., Windrem, M., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2012.12.002 · Cited by 586

A regenerative approach to the treatment of multiple sclerosis

Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., et al. (2013) · Nature · doi:10.1038/nature12647 · Cited by 531

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

Reinhardt, P., Glatza, M., Hemmer, K., Tsytsyura, Y., Thiel, C. S., Höing, S., Moritz, S., Parga, J. A., Wagner, L., Bruder, J. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059252 · Cited by 461

Invited review: Frontotemporal dementia caused by microtubule‐associated protein tau gene ( MAPT ) mutations: a chameleon for neuropathology and neuroimaging

Ghetti, B. F., Oblak, A. L., Boeve, B. F., Johnson, K. A., Dickerson, B. C., & Goedert, M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12213 · Cited by 458

A culture system to study oligodendrocyte myelination processes using engineered nanofibers

Lee, S., Leach, M. K., Redmond, S., Chong, S. Y. C., Mellon, S. H., Tuck, S. J., Feng, Z. Q., Corey, J. M., & Chan, J. R. (2012) · Nature Methods · doi:10.1038/nmeth.2105 · Cited by 455

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

Najm, F. J., Madhavan, M., Zaremba, A., Shick, E., Karl, R. T., Factor, D. C., Miller, T. E., Nevin, Z. S., Kantor, C., Sargent, A., et al. (2015) · Nature · doi:10.1038/nature14335 · Cited by 424

Using iPSC models to examine neuron–glia interactions in neurodegenerative diseases

Lopez, D. M., Keavey, L., & Bowles, K. R. (2026) · Bioscience Reports · doi:10.1042/bsr20250131 · Cited by 2

Translating Alzheimer’s disease proteomics into drug discovery opportunities

Drummond, E., Werry, E. L., Kavanagh, T., Genoud, S., Cho, A., Chen, S., Du, J., Hibbs, D. E., & Kassiou, M. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00035-y · Cited by 2

Modeling rare pediatric neurogenetic disorders with IPSCs

Kim, J., Nonis, D., Otero, M. G., & Pierson, T. M. (2019) · AIMS Cell and Tissue Engineering · doi:10.3934/celltissue.2019.1.1 · Cited by 2

Bipolar disorder as a gliopathy

Stertz, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00015-6 · Cited by 2

Glial cell transplant for brain diseases: the supportive saviours?

Albert, K., Goldsteins, G., Kälvälä, S., Jolkkonen, J., & Lehtonen, Š. (2024) · Translational Medicine Communications · doi:10.1186/s41231-024-00182-y · Cited by 3

Oligodendrocytes in Huntington's Disease: A Review of Oligodendrocyte Pathology and Current Cell Reprogramming Approaches for Oligodendrocyte Modelling of Huntington's Disease

Back, A. M., Connor, B. J., & McCaughey‐Chapman, A. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.70010 · Cited by 3

Repurposed Drugs to Enhance the Therapeutic Potential of Oligodendrocyte Precursor Cells Derived from Adult Rat Adipose Tissue

Pascual-Guerra, J., Torres-Rico, M., Marín-Rodríguez, B., Arasmou-Idrovo, M. S., Garcı́a, A. G., Rodríguez-Navarro, J. A., & Paı́no, C. L. (2025) · Cells · doi:10.3390/cells14070533 · Cited by 2

Cellular and molecular neurobiology of autism spectrum disorder

Chapman, G., Antony, I., Narasimhan, M., Shen, R., Elman, R., & Kroll, K. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-816393-1.00007-5 · Cited by 2

In vitro models for human neuroglia

Lendemeijer, B., & de Vrij, F. M. S. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00015-2 · Cited by 1

Establishing validity standards for iPSC modeling of neuropsychiatric disorders

Kolsters, N., Vernon, A. C., Kasri, N. N., & Latour, B. L. (2025) · Genomic psychiatry : · doi:10.61373/gp025p.0074 · Cited by 1

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes

Wihan, J., Battis, K., Hoffmann, A., Windener, F., Himmler, M., Varghese, A., Koller, A., Karnatz, I., Schubert, D. W., Zunke, F., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02933-z · Cited by 1

Characterising processing conditions that artifactually bias human brain tissue transcriptomes

Yaqubi, M., Thomas, M., Talbot-Martin, J., Mohammadnia, A., Allot, A., Groh, A. M. R., Fancy, N. N., Papageorgopoulou, M., Zhang, X., McGarry, A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68872-9 · Cited by 2

Proteomic comparison of human neural cell-derived extracellular vesicles and parental cells from Alzheimer’s disease and cognitively normal individuals

Xin, J., Liu, J., Dong, H.-M., Yu, H., Xiao, Z., Hu, J.-N., Jiang, Q., Zhu, Y.-P., Feng, L., Feng, Y., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3243-2 · Cited by 2

Generation of Functional Oligodendrocyte Progenitor Cells Through Serial Replating of iPSC-Derived NPC Spheres

Park, J., Kang, S., Kim, S., Kim, D., Shin, B., Mun, J. Y., Park, Y., Kim, J., Goldman, S. A., & Kim, K.-P. (2026) · Cells · doi:10.3390/cells15121067 · Cited by 1

Organoids: the third dimension of human brain development and disease

Kouroupi, G., Prodromidou, K., Papastefanaki, F., Taoufik, E., & Matsas, R. (2021) · The International Journal of Developmental Biology · doi:10.1387/ijdb.210158gk · Cited by 1

iPSCs and toxicology

Bertero, A., Coccini, T., & Caloni, F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99892-5.00022-0 · Cited by 1

Human neural stem cells in developmental neurotoxicology: Current scenario and future prospects

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Induced neural stem cells-derived spinal cord progenitor cells as stable stage for rapid and efficient generation of human oligodendrocytes and motor neurons

Tang, X., Yu, M., Liao, C., Lan, S., & Fan, Y. (2020) · Connective Tissue Research · doi:10.1080/03008207.2019.1670651 · Cited by 2

The therapeutic potential of exogenous adult stem cells for the injured central nervous system

Smith, J. A., Braga, A., Hamel, R., Rutigliani, C., Yu, B., Peruzzotti‐Jametti, L., & Pluchino, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818084-6.00006-4 · Cited by 1

Derivation of oligodendrocyte precursor cells from human bone marrow stromal cells and use for re-myelination in the congenitally dysmyelinated brainPreprint

Lam, G., Shea, G. K., Wu, L. K., Sui, M. L. T., Hei, K. C., Chan, Z. C.-K., Yin, Y. W. C., Tsui, A. Y. P., Shum, D. K., & Chan, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/658997 · Cited by 1

Oligodendrocytes in human iPS cell-derived cortical grafts remyelinate adult rat and human cortical neuronsPreprint

Martínez-Curiel, R., Jansson, L., Tsupykov, O., Avaliani, N., Aretio-Medina, C., Hidalgo, I., Monni, E., Bengzon, J., Skibo, G. G., Lindvall, O., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.24.534133 · Cited by 1

Targeting UBE3A and downstream estrogen receptor-β signaling to restore oligodendroglial homeostasis in Angelman syndromePreprint

Yang, X., Mayoral, S., Jiang, Y.-H., Marshall, J., & Huang, Y. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.21.726878 · Cited by 1

Human-Induced Pluripotent Stem Cell-Derived Neurons to Model and Gain Insights into Alzheimer’s Disease Pathogenesis

Young, J. E., & Delgado‐Morales, R. (2018) · Springer eBooks · doi:10.1007/978-3-319-90695-9_1

Remyélinisation du système nerveux central et sclérose en plaques

Dubessy, A., & Stankoff, B. (2019) · Elsevier eBooks · doi:10.1016/b978-2-294-71420-7.00007-0

Canine induced pluripotent stem cells: an in vitro approach to validate the dog as a large animal model for Alzheimer’s disease

Pessôa, L. V. D. F., Chandrasekaran, A., Thomsen, B. B., Berendt, M., Hyttel, P., & Freude, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822228-7.00010-2

Studying non–cell-autonomous neurodegeneration in Parkinson’s disease with induced pluripotent stem cells

Sonninen, T.-M., Plotnikova, L. M., Laham-Karam, N., Goldsteins, G., Koıstınaho, J., & Lehtonen, Š. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85764-2.00009-0

Hacia una etica global

Singer, P. (2003) · Claves de razón práctica

Methodology of neuronal pluripotent stem cell of in vitro difference process as an alternative therapy of neurodegenerative disease

Wulansari, W., Torizal, F. G., Khumaira, A., & Nugraheni, I. A. (2022) · JHeS (Journal of Health Studies) · doi:10.31101/jhes.1730

Faculty Opinions recommendation of Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.

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PLURİPOTENT KÖK HÜCRELERDEN SİNİR HÜCRELERİNE FARKLILAŞTIRMA YÖNTEMLERİ

Kuruş, M., Ergin, K., & Çetinkaya, R. (2022) · SDÜ Tıp Fakültesi Dergisi · doi:10.17343/sdutfd.1103596 · Cited by 2

Development of transcription factor-based strategies for neuronal differentiation from pluripotent stem cells

Chou, H., Mao, X., & Ying, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822277-5.00003-1

Immune function of LRRK2

Oun, A. (2022) · doi:10.33612/diss.253651629

Models of Neurodegenerative Diseases

Maharjan, N., & Saxena, S. (2022) · Learning materials in biosciences · doi:10.1007/978-3-031-07793-7_10 · Cited by 1

Manipulation of extracellular matrix mechanical cues to stimulate oligodendrocytes to promote remyelination

Bennett, I., & Joykutty, L. (2021) · Journal of Emerging Investigators · doi:10.59720/20-025

Advancing Towards Physiologically Relevant Models of the Brain: Three-Dimensional Human Induced Pluripotent Stem Cell (hiPSC)-Based Cell Culture Systems in Neuroscience

von der Bey, M., & Ercan-Herbst, E. (2023) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2023/2.1290

Oligodendrocytes in multiple sclerosis

Pernin, F., Kuhlmann, T., Kennedy, T. E., & Antel, J. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-823848-6.00009-9

Complementary strategies to be used in conjunction with animal models for multiple sclerosis drug discovery: adapting preclinical validation of drug candidates to the need of remyelinating strategies

Askar, I. C., Spenlé, C., & Bagnard, D. (2024) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2024.2382180

To recruit or to graft? Comparing the recruitment of resident non-neuronal cells by lineage reprogramming with engraftment of stem cell-derived neurons for neuronal replacement therapies

Peterson, D. A. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1589790

An Efficient Electroporation Protocol Supporting In Vitro Studies of Oligodendrocyte Biology

Ishino, Y., Shimizu, S., & Miyata, S. (2025) · Methods and Protocols · doi:10.3390/mps8030064

Additional file 1 of Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS

Gerhards, R., Pfeffer, L. K., Lorenz, J., Starost, L. J., Nowack, L., Thaler, F., Schlüter, M., Rübsamen, H., Macrini, C., Winklmeier, S., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13311369

Additional file 4 of Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

Supakul, S., Murakami, R., Oyama, C., Shindo, T., Hatakeyama, Y., Itsuno, M., Bannai, H., Shibata, S., Maeda, S., & Okano, H. (2024) · Figshare · doi:10.6084/m9.figshare.26686686

Additional file 2 of Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

Supakul, S., Murakami, R., Oyama, C., Shindo, T., Hatakeyama, Y., Itsuno, M., Bannai, H., Shibata, S., Maeda, S., & Okano, H. (2024) · Figshare · doi:10.6084/m9.figshare.26686680

Additional file 3 of Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

Supakul, S., Murakami, R., Oyama, C., Shindo, T., Hatakeyama, Y., Itsuno, M., Bannai, H., Shibata, S., Maeda, S., & Okano, H. (2024) · Figshare · doi:10.6084/m9.figshare.26686683

Additional file 1 of Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

Supakul, S., Murakami, R., Oyama, C., Shindo, T., Hatakeyama, Y., Itsuno, M., Bannai, H., Shibata, S., Maeda, S., & Okano, H. (2024) · Figshare · doi:10.6084/m9.figshare.26686677

Protocol for the generation and xenotransplantation of human induced pluripotent stem cell-derived neural progenitor cells into the mouse forebrain

McInvale, J. J., Ayers, C. E., Sarmah, H., Kim, K., Reinhardt, P., Mahajan, A., Humala, N., Corneo, B., Sterneckert, J. L., Canoll, P., et al. (2026) · STAR Protocols · doi:10.1016/j.xpro.2025.104305

Stepwise Chemically Defined Differentiation of Human iPSCs into Oligodendrocytes with Harvestable Developmental Intermediates

Parameswaran, S. (2026) · Current Protocols · doi:10.1002/cpz1.70320

Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts

Alemany‐Ribes, M., Pérez‐Soriano, A., Santos, A., Severino, J., Dangla-Valls, A., Gigirey-Suárez, M., Cohen, D., Ezquerra, M., Fernandez-Santiago, R., Fernández, M., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1641981

Landslides and Mass Movements

Kumar, P. P., & Kumar, S. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-6274-8.ch008

Efficient Induction of Oligodendrocyte Lineage From Pluripotent Stem Cells via Temporal Modulation of OLIG2 ( S147A ) and SOX10

Ishikawa, M., Izumizawa, Y., Supakul, S., & Okano, H. (2026) · Genes to Cells · doi:10.1111/gtc.70106

Les organoïdes cérébraux : nouvelle plateforme pour la modélisation de pathologies neurodéveloppementales et neurodégénératives

Leleu, A. (2024) · theses.fr (ABES) · doi:10.70675/ed51e8c8z02f2z4fd5zb086z7955f0ad9c0f

Pharmacogenomic identification of small molecules promoting oligodendrogenesis and myelin repair

Huré, J.-B. (2022) · theses.fr (ABES) · doi:10.70675/17691e80z7bacz455fzba89z49fef7be0512

Nanofiber-based platform for quantitative analysis of human oligodendrocyte ensheathment with pharmacological perturbations

Morita, S., Kondo, T., Imamura, K., Sagara, Y., Tsukita, K., Tokuda, H., Kaneda, Y., Izumo, T., Nakao, Y., & Inoue, H. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102923

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer’s Disease pathologyPreprint

Byrne, A., Hoover, J., Lund, J. M., Zhang, A., Shan, X., Sharma, A. D., Chen, X., Xavier‐Magalhães, A., Phu, L., Choi, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.18.724443 · Cited by 2

Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson’s disease-relevant LRRK2-G2019S mutation

Karmali, N., Kessler, W., Dehestani, M., Sun, W., Drwesh, L., Volos, P., Tsitkov, S., Dhingra, A., Thomas, C., Rodrı́guez-Nieto, S., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116368 · Cited by 3

Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimer’s diseasePreprint

Shin, J., Joshi, N., Miller, B., Vellarikkal, S., Huang, J., Wu, F., Cui, Y., Murali, A., Chason, J., Campbell, C. S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.08.737318

Rapid Generation of Functional Oligodendrocytes From Human Induced Pluripotent Stem Cells Through Small Molecule Guided Differentiation

Bienjonetti, I., Roy, V., Beaudet, M., Louit, A., Martineau, L., Berthod, F., Dupré, N., & Gros‐Louis, F. (2026) · Journal of Neuroscience Research · doi:10.1002/jnr.70155

Multicellular Co-development Promotes Maturation of Human Stem Cell-Derived Neural NetworksPreprint

Čarná, M., Feole, M., Devoto, V. M. P., Novotný, J., Klosterman, K. E., Jurič, D. M., Jáuregui, G. V., Dragišić, N., Srt, L., Salem, T., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10956881/v1

Human-induced pluripotent stem cell-derived neural cells to model epigenetic regulations in the nervous system and brain disorders in vitro

HONG, Y., Ming, G.-L., & SONG, H. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19043-8.00002-5

Single Transcription Factor-Based Differentiation Allowing Fast and Efficient Oligodendrocyte Generation via SOX10 Overexpression

Neyrinck, K., & García‐León, J. A. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1601-7_11 · Cited by 11

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

García‐León, J. A., Kumar, M., Boon, R., Chau, D., One, J., Wolfs, E., Eggermont, K., Berckmans, P., Gunhanlar, N., de Vrij, F. M. S., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.014 · Cited by 123

Rapid Generation of Functional Oligodendrocytes From Human Induced Pluripotent Stem Cells Through Small Molecule Guided Differentiation

Bienjonetti, I., Roy, V., Beaudet, M., Louit, A., Martineau, L., Berthod, F., Dupré, N., & Gros‐Louis, F. (2026) · Journal of Neuroscience Research · doi:10.1002/jnr.70155

Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2

Li, P., Li, M., Tang, X., Wang, S., Zhang, Y. A., & Chen, Z. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0165-3 · Cited by 25

Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells

García-León, J., García-Díaz, B., Eggermont, K., Cáceres-Palomo, L., Neyrinck, K., da Costa, R. F. M., Davila, J., Evercooren, A. B.-V., Gutierrez, A., & Verfaillie, C. (2020) · Nature Protocols · doi:10.1038/s41596-020-0395-4 · Cited by 44