Antel, Jack P.

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 2,543

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

Hauser, S. L., Waubant, E., Arnold, D. L., Vollmer, T., Antel, J., Fox, R. J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., et al. (2008) · New England Journal of Medicine

Multiple Sclerosis Research StudiesPolyomavirus and related diseases

Cited by 2,439

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C.-C., Patel, B., Yan, R., Blain, M., et al. (2016) · Nature Medicine

Tryptophan and brain disordersinterferon and immune responses

Cited by 1,559

iPSC-derived human microglia-like cells to study neurological diseases

Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron

Neuroinflammation and Neurodegeneration MechanismsPluripotent Stem Cells Research

Cited by 1,154

Microglial control of astrocytes in response to microbial metabolites

Rothhammer, V., Borucki, D. M., Tjon, E. C., Takenaka, M. C., Chao, C.-C., Ardura-Fabregat, A., de Lima, K. A., Gutiérrez-Vázquez, C., Hewson, P., Staszewski, O., et al. (2018) · Nature

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 1,051

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Kappos, L., Bar-Or, A., Cree, B. A. C., Fox, R. J., Giovannoni, G., Gold, R., Vermersch, P., Arnold, D. L., Arnould, S., Scherz, T., et al. (2018) · The Lancet

Multiple Sclerosis Research StudiesSphingolipid Metabolism and Signaling

Cited by 942

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 864

TLR signaling tailors innate immune responses in human microglia and astrocytes

Jack, C. S., Arbour, N., Manusow, J., Montgrain, V., Blain, M., McCrea, E., Shapiro, A., & Antel, J. P. (2005) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 734

An updated histological classification system for multiple sclerosis lesions

Kuhlmann, T., Ludwin, S., Prat, A., Antel, J., Brück, W., & Lassmann, H. (2017) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 692

A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response

Haenseler, W., Sansom, S. N., Buchrieser, J., Newey, S. E., Moore, C. S., Nicholls, F. J., Chintawar, S., Schnell, C., Antel, J. P., Allen, N. D., et al. (2017) · Stem Cell Reports

Neuroinflammation and Neurodegeneration MechanismsPluripotent Stem Cells Research

Cited by 593

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Takenaka, M. C., Gabriely, G., Rothhammer, V., Mascanfroni, I. D., Wheeler, M. A., Chao, C.-C., Gutiérrez-Vázquez, C., Kenison, J., Tjon, E. C., Barroso, A., et al. (2019) · Nature Neuroscience

Immune cells in cancerGlioma Diagnosis and Treatment

Cited by 517

MAFG-driven astrocytes promote CNS inflammation

Wheeler, M. A., Clark, I. C., Tjon, E. C., Li, Z., Zandee, S. E. J., Couturier, C. P., Watson, B. R., Scalisi, G., Alkwai, S., Rothhammer, V., et al. (2020) · Nature

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 501

Remyelination capacity of the MS brain decreases with disease chronicity

Goldschmidt, T., Antel, J., König, F. B., Brück, W., & Kuhlmann, T. (2009) · Neurology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 411

Glial cell influence on the human blood‐brain barrier

Prat, A., Biernacki, K., Wosik, K., & Antel, J. P. (2001) · Glia

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 334

Extensive cortical remyelination in patients with chronic multiple sclerosis

Albert, M., Antel, J., Brück, W., & Stadelmann, C. (2007) · Brain Pathology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 314

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Clark, I. C., Gutiérrez-Vázquez, C., Wheeler, M. A., Li, Z., Rothhammer, V., Linnerbauer, M., Sanmarco, L. M., Guo, L., Blain, M., Zandee, S. E. J., et al. (2021) · Science

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 285

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors

Ehrlich, M., Mozafari, S., Glatza, M., Starost, L., Velychko, S., Hallmann, A.-L., Cui, Q.-L., Schambach, A., Kim, K.-P., Bachelin, C., et al. (2017) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 257

miR‐155 as a multiple sclerosis–relevant regulator of myeloid cell polarization

Moore, C. S., Rao, V. T. S., Durafourt, B. A., Bedell, B. J., Ludwin, S. K., Bar‐Or, A., & Antel, J. P. (2013) · Annals of Neurology

Multiple Sclerosis Research StudiesMicroRNA in disease regulation

Cited by 219

P2Y12 expression and function in alternatively activated human microglia

Moore, C. S., Ase, A. R., Kinsara, A., Rao, V. T. S., Michell-Robinson, M., Leong, S. Y., Butovsky, O., Ludwin, S. K., Séguéla, P., Bar-Or, A., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic Signaling

Cited by 212

Determinants of Human B Cell Migration Across Brain Endothelial Cells

Alter, A., Duddy, M., Hebert, S., Biernacki, K., Prat, A., Antel, J. P., Yong, V. W., Nuttall, R. K., Pennington, C. J., Edwards, D. R., et al. (2003) · The Journal of Immunology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 195

Neuroleukin: A Lymphokine Product of Lectin-Stimulated T Cells

Gurney, M. E., Apatoff, B. R., Spear, G. T., Baumel, M. J., Antel, J. P., Bania, M. B., & Reder, A. T. (1986) · Science

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 195

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

Owen, D. R., Narayan, N., Wells, L., Healy, L., Smyth, E., Rabiner, E. A., Galloway, D., Williams, J. B., Lehr, J., Mandhair, H., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism

Neuroinflammation and Neurodegeneration MechanismsPharmacological Receptor Mechanisms and Effects

Cited by 194

Netrin 1 regulates blood–brain barrier function and neuroinflammation

Podjaski, C., Alvarez, J. I., Bourbonniere, L., Larouche, S., Terouz, S., Bin, J. M., Lécuyer, M.-A., Saint-Laurent, O., Larochelle, C., Darlington, P. J., et al. (2015) · Brain

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 185

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

Healy, L. M., Perron, G., Won, S.-Y., Michell-Robinson, M. A., Rezk, A., Ludwin, S. K., Moore, C. S., Hall, J. A., Bar-Or, A., & Antel, J. P. (2016) · The Journal of Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 174