Cited by 166HIV Research and TreatmentVirus-based gene therapy researchHIV/AIDS drug development and treatment

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Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

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Wiegand, Ann, Spindler, Jonathan, Hong, Feiyu F., Shao, Wei, Cyktor, Joshua C., Cillo, Anthony R., Halvas, Elias K., Coffin, John M., Mellors, John W., Kearney, Mary F.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1617961114PMC PMC5422779

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Abstract

Significance: Previously, we showed that the virus that persists in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy (ART) is derived from cells infected prior to initiating treatment. We also showed that HIV-infected cells can undergo cellular proliferation during ART. However, it is not known what fraction of infected cells that persist during ART are latent and what fraction are actively producing HIV RNA. The method described here was developed to determine the fraction of infected cells that produce HIV RNA and the levels of HIV RNA in single cells, including cells that have undergone cellular proliferation. Additionally, the method can be used to identify the sources of rebound virus after stopping ART and the efficacy of experimental interventions designed to cure HIV infection.

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Authors: Wiegand, A., Spindler, J., Hong, F. F., Shao, W., Cyktor, J. C., Cillo, A. R., Halvas, E. K., Coffin, J. M., Mellors, J. W., & Kearney, M. F.
Affiliations: National Cancer Institute (US)
University of Pittsburgh (US)
Frederick National Laboratory for Cancer Research (US)
Tufts University (US)
ORCID: Shao, Wei
Cyktor, Joshua C.
Cillo, Anthony R.
Halvas, Elias K.
Coffin, John M.
Mellors, John W.
Kearney, Mary F.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-04-17
Volume: 114
Issue: 18
Pages: E3659-E3668
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1617961114
PMC: PMC5422779
OpenAlex: W2606857030
Cited by: 165
References: 44
Citations by year: 2026: 8 · 2025: 19 · 2024: 15 · 2023: 17 · 2022: 15 · 2021: 19 · 2020: 25 · 2019: 19 · 2018: 23 · 2017: 4
FWCI: 10.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | NIH | National Cancer Institute (Intramural Funding, 1U01CA200441)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: HIV-1, unspliced viral RNA, single-genome sequencing, antiretroviral therapy, viral reservoir, defective proviruses, HIV transcription, viremia, blood mononuclear cells
MeSH terms: Female, Humans, Leukocytes, Mononuclear, Male, Proviruses, RNA, Viral, Transcription, Genetic, HIV-1, Gene Expression Regulation, Viral, Anti-Retroviral Agents

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Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

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