Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N -cadherin balance in mural cell–endothelial cell-regulated barrier function

Alimperti, Stella; Mirabella, Teodelinda; Bajaj, Varnica; Polacheck, William; Pirone, Dana M.; Duffield, Jeremy; Eyckmans, Jeroen; Assoian, Richard K.; Chen, Christopher S.

doi:10.1073/pnas.1618333114

Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N -cadherin balance in mural cell–endothelial cell-regulated barrier function

Significance Organ homeostasis requires integrity of blood vessels; alterations or disruption of the vascular barrier between blood and tissue contribute to numerous diseases. Endothelial cells and mural cells are two key cell types, which play significant roles for the maintenance of barrier fun…