Chen, Christopher S.

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D.-H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., et al. (2012) · Nature Materials

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 1,917

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science

Cellular Mechanics and Interactions3D Printing in Biomedical Research

Cited by 1,760

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

Fu, J., Wang, Y.-K., Yang, M. T., Desai, R. A., Yu, X., Liu, Z., & Chen, C. S. (2010) · Nature Methods

Cellular Mechanics and Interactions3D Printing in Biomedical Research

Cited by 1,073

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

Hinson, J. T., Chopra, A., Nafissi, N., Polacheck, W. J., Benson, C. C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C. C., et al. (2015) · Science

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 638

Nanopattern-induced changes in morphology and motility of smooth muscle cells

Yim, E. K. F., Reano, R. M., Pang, S. W., Yee, A. F., Chen, C. S., & Leong, K. W. (2005) · Biomaterials

Cellular Mechanics and InteractionsNanofabrication and Lithography Techniques

Cited by 628

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

Baker, B. M., Trappmann, B., Wang, W. Y., Sakar, M. S., Kim, I. L., Shenoy, V. B., Burdick, J. A., & Chen, C. S. (2015) · Nature Materials

Cellular Mechanics and InteractionsHydrogels: synthesis, properties, applications

Cited by 556

A multi-organ chip with matured tissue niches linked by vascular flow

Ronaldson-Bouchard, K., Teles, D., Yeager, K., Tavakol, D. N., Zhao, Y., Chramiec, A., Tagore, S., Summers, M., Stylianos, S., Tamargo, M., et al. (2022) · Nature Biomedical Engineering

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 512

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

Song, H.-H. G., Rumma, R. T., Ozaki, C. K., Edelman, E. R., & Chen, C. S. (2018) · Cell Stem Cell

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Cited by 476

Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro

Hassell, B. A., Goyal, G., Lee, E., Sontheimer-Phelps, A., Levy, O., Chen, C. S., & Ingber, D. E. (2017) · Cell Reports

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 467

A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues

Boudou, T., Legant, W. R., Mu, A., Borochin, M. A., Thavandiran, N., Radisic, M., Zandstra, P. W., Epstein, J. A., Margulies, K. B., & Chen, C. S. (2012) · Tissue Engineering Part A

Tissue Engineering and Regenerative MedicineCellular Mechanics and Interactions

Cited by 413

Engineering cellular microenvironments to improve cell-based drug testing

Bhadriraju, K., & Chen, C. S. (2002) · Drug Discovery Today

Cellular Mechanics and Interactions3D Printing in Biomedical Research

Cited by 355

Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers

Wang, H., Abhilash, A. S., Chen, C. S., Wells, R. G., & Shenoy, V. B. (2014) · Biophysical Journal

Cellular Mechanics and InteractionsElasticity and Material Modeling

Cited by 313

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues

Thavandiran, N., Dubois, N., Mikryukov, A., Massé, S., Beca, B., Simmons, C. A., Deshpande, V. S., McGarry, J. P., Chen, C. S., Nanthakumar, K., et al. (2013) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 285

Geometric control of vascular networks to enhance engineered tissue integration and function

Baranski, J. D., Chaturvedi, R. R., Stevens, K. R., Eyckmans, J., Carvalho, B., Solorzano, R. D., Yang, M. T., Miller, J. S., Bhatia, S. N., & Chen, C. S. (2013) · Proceedings of the National Academy of Sciences

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Cited by 267

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

Vandenberghe, L. H., Wang, L., Somanathan, S., Zhi, Y., Figueredo, J., Calcedo, R., Sanmiguel, J., Desai, R. A., Chen, C. S., Johnston, J., et al. (2006) · Nature Medicine

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 208

Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy

Schadler, K. L., Thomas, N. J., Galie, P. A., Bhang, D. H., Roby, K. C., Addai, P., Till, J. E., Sturgeon, K., Zaslavsky, A., Chen, C. S., et al. (2016) · Oncotarget

Angiogenesis and VEGF in CancerMathematical Biology Tumor Growth

Cited by 199

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

Nguyen, D.-H. T., Lee, E., Alimperti, S., Norgard, R. J., Wong, A., Lee, J. J.-K., Eyckmans, J., Stanger, B. Z., & Chen, C. S. (2019) · Science Advances

Pancreatic and Hepatic Oncology ResearchAngiogenesis and VEGF in Cancer

Cited by 172

Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N -cadherin balance in mural cell–endothelial cell-regulated barrier function

Alimperti, S., Mirabella, T., Bajaj, V., Polacheck, W., Pirone, D. M., Duffield, J., Eyckmans, J., Assoian, R. K., & Chen, C. S. (2017) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 122

Engineering a living cardiac pump on a chip using high-precision fabrication

Michas, C., Karakan, M. Ç., Nautiyal, P., Seidman, J. G., Seidman, C. E., Agarwal, A., Ekinci, K., Eyckmans, J., White, A. E., & Chen, C. S. (2022) · Science Advances

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 82

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs

Chen, G., Li, S., Karakikes, I., Ren, L., Zi-Ying Chow, M., Chopra, A., Keung, W., Yan, B., Chan, C. W. Y., Costa, K. D., et al. (2015) · Circulation: Arrhythmia and Electrophysiology

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 38