The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice
Open accessAbstract
Significance: Middle East respiratory syndrome, caused by a zoonotically transmitted coronavirus (MERS-CoV), has a high mortality (∼36%). Because of limited autopsy data on tissues from MERS fatalities, a small animal model can provide an important tool to better understand the disease. We humanized the mouse locus of the virus receptor DPP4, preserving native DPP4 expression. After inoculating hDPP4 knockin mice with MERS-CoV, there was virus replication without disease. We then generated a mouse-adapted MERS-CoV by serial passage in hDPP4 knockin mice. The resultant virus causes fatal lung disease that includes diffuse alveolar damage and immune dysregulation. Here, we characterize the pathologic features of the model and elucidate key aspects of the immunopathology and factors contributing to virulence.
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Cites
Structure, Function, and Evolution of Coronavirus Spike Proteins
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
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Li, K., Wohlford-Lenane, C., Perlman, S., Zhao, J., Jewell, A. K., Reznikov, L. R., Gibson-Corley, K. N., Meyerholz, D. K., & McCray, P. B. (2016) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv499 · Cited by 459
Self-citationCameron, M. J., Ran, L., Xu, L., Danesh, A., Bermejo-Martin, J. F., Cameron, C. M., Muller, M. P., Gold, W. L., Richardson, S. E., Poutanen, S. M., et al. (2007) · Journal of Virology · doi:10.1128/jvi.00527-07 · Cited by 386
Pulmonary pathology of severe acute respiratory syndrome in Toronto
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Cited by
Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524
Self-citationMuñoz-Fontela, C., Dowling, W. E., Funnell, S. G. P., Gsell, P.-S., Riveros-Balta, A. X., Albrecht, R. A., Andersen, H., Baric, R. S., Carroll, M. W., Cavaleri, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2787-6 · Cited by 798
Self-citationGeneration of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
Sun, J., Zhuang, Z., Zheng, J., Li, K., Wong, R. L.-Y., Liu, D., Huang, J., He, J., Zhu, A., Zhao, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.010 · Cited by 447
Self-citationKulcsar, K. A., Coleman, C. M., Beck, S. E., & Frieman, M. B. (2019) · JCI Insight · doi:10.1172/jci.insight.131774 · Cited by 373
Lessons for COVID-19 immunity from other coronavirus infections
Sariol, A., & Perlman, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.005 · Cited by 317
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Metadata
- Authors
- Li, K., Wohlford-Lenane, C. L., Channappanavar, R., Park, J.-E., Earnest, J. T., Bair, T. B., Bates, A. M., Brogden, K. A., Flaherty, H. A., Gallagher, T., Meyerholz, D. K., Perlman, S., & McCray, P. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-03-27
- Volume
- 114
- Issue
- 15
- Pages
- E3119-E3128
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2600589974
- Cited by
- 183
- References
- 7
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, K., Wohlford-Lenane, C. L., Channappanavar, R., Park, J.-E., Earnest, J. T., Bair, T. B., Bates, A. M., Brogden, K. A., Flaherty, H. A., Gallagher, T., Meyerholz, D. K., Perlman, S., & McCray, P. B. (2017). Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1619109114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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