Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy
Abstract
Tumor hypoxia is one of the major challenges for the treatment of tumors, as it may negatively affect the efficacy of various anticancer modalities. In this study, a tumor-targeted redox-responsive composite biocatalyst is designed and fabricated, which may combine tumor starvation therapy and low-temperature photothermal therapy for the treatment of oxygen-deprived tumors. The nanosystem was prepared by loading porous hollow Prussian Blue nanoparticles (PHPBNs) with glucose oxidase (GOx) and then coating their surface with hyaluronic acid (HA) via redox-cleavable linkage, therefore allowing the nanocarrier to bind specifically with CD44-overexpressing tumor cells while also exerting control over the cargo release profile. The nanocarriers are designed to enhance the efficacy of the hypoxia-suppressed GOx-mediated starvation therapy by catalyzing the decomposition of intratumoral hydroperoxide into oxygen with PHPBNs, and the enhanced glucose depletion by the two complementary biocatalysts may consequently suppress the expression of heat shock proteins (HSPs) after photothermal treatment to reduce their resistance to the PHPBN-mediated low-temperature photothermal therapies.
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H2S-based gas therapy is capable of inducing oxidative stress and downregulating ATP-dependent HSP90 synthesis.
“Hydrogen sulfide (H2S)-based gas therapy is capable of inducing oxidative stress and downregulating ATP-dependent HSP90 synthesis, making its combination with PTT a promising approach to achieve synergistic therapeutic effects233.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [233]
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“Hydrogen sul fi de (H 2 S)-based gas therapy is capable of inducing oxidative stress and downregulating ATP-dependent HSP90 synthesis, making its combination with PTT a promising approach to achieve synergistic therapeutic effects 233 .”
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- Authors
- Zhou, J., Li, M., Hou, Y., Luo, Z., Chen, Q., Cao, H., Huo, R., Xue, C., Sutrisno, L., Hao, L., Cao, Y., Ran, H., Lu, L., Li, K., & Cai, K.
- Affiliations
- Chongqing University (CN)
- Chongqing Medical and Pharmaceutical College (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Corresponding author
- Luo, Zhong
- Cai, Kaiyong
- ORCID
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-03-06
- Volume
- 12
- Issue
- 3
- Pages
- 2858-2872
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2791022934
- Cited by
- 424
- References
- 49
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 41 · 2023: 56 · 2022: 62 · 2021: 80 · 2020: 72 · 2019: 57 · 2018: 16
- FWCI
- 22.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2016YFC1100300)
- Ministry of Education of the People's Republic of China (10611CDJXZ238826)
- China Postdoctoral Science Foundation (2017M612919)
- National Natural Science Foundation of China (51603024, 51602034)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- tumor hypoxia, photothermal therapy, glucose oxidase, Prussian blue nanoparticles, biocatalysts, tumor starvation therapy, hyaluronic acid, CD44 targeting, redox-responsive drug release, hydroperoxide decomposition, oxygen production, heat shock proteins, low-temperature photothermal therapy, glucose depletion
- MeSH terms
- Animals, Ferrocyanides, Glucose, Glucose Oxidase, Humans, Hydrogen Peroxide, Hyperthermia, Induced, Mice, Nude, Neoplasms, Oxygen, Phototherapy, Temperature, Drug Delivery Systems, Mice, Nanoparticles, Hep G2 Cells
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