Cited by 239Antifungal resistance and susceptibilityBacterial biofilms and quorum sensingAntimicrobial Peptides and Activities

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Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans

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Graham, Carrie E., Cruz, Melissa R., Garsin, Danielle A., Lorenz, Michael C.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1620432114PMC PMC5410809

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Abstract

Significance: Hospitalized patients are susceptible to serious infections that are rarely encountered by healthy people. Two of the most problematic causes are Enterococcus faecalis and Candida albicans , a bacterium and fungus, respectively. Both are members of our normal microbial communities, but cause significant mortality in immunocompromised individuals. The formation of biofilms—microbial communities that grow on biotic or artificial surfaces—is a common feature of these infections and presents a formidable barrier to their treatment. We show here that E. faecalis produces a small protein that is a potent inhibitor of the ability of C. albicans to form biofilms and reduces fungal virulence in several models, raising the possibility that it might be developed as an antifungal agent.

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Authors: Graham, C. E., Cruz, M. R., Garsin, D. A., & Lorenz, M. C.
Affiliations: Department of Microbiology and Molecular Genetics, University of Texas McGovern Medical School, Houston, TX 77030;
The University of Texas Health Science Center at Houston (US)
ORCID: Graham, Carrie E.
Cruz, Melissa R.
Garsin, Danielle A.
Lorenz, Michael C.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-04-10
Volume: 114
Issue: 17
Pages: 4507-4512
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1620432114
PMC: PMC5410809
OpenAlex: W2607320059
Cited by: 239
References: 66
Citations by year: 2026: 16 · 2025: 29 · 2024: 21 · 2023: 25 · 2022: 25 · 2021: 32 · 2020: 32 · 2019: 27 · 2018: 24 · 2017: 8
FWCI: 19.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI075091, R01AI076406, R01AI110432, F31AI122725)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords: Enterococcus faecalis, Candida albicans, hyphal morphogenesis, biofilm formation, fungal virulence, antifungal agents, fungal-bacterial interactions, opportunistic infections, immunocompromised patients
MeSH terms: RAW 264.7 Cells, Animals, Bacteriocins, Candida albicans, Candidiasis, Macrophages, Mice, Inbred BALB C, Oropharynx, Enterococcus faecalis, Virulence, Caenorhabditis elegans, Biofilms, Hyphae, Mice

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Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans

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