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Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans
Open accessAbstract
Significance: Hospitalized patients are susceptible to serious infections that are rarely encountered by healthy people. Two of the most problematic causes are Enterococcus faecalis and Candida albicans , a bacterium and fungus, respectively. Both are members of our normal microbial communities, but cause significant mortality in immunocompromised individuals. The formation of biofilms—microbial communities that grow on biotic or artificial surfaces—is a common feature of these infections and presents a formidable barrier to their treatment. We show here that E. faecalis produces a small protein that is a potent inhibitor of the ability of C. albicans to form biofilms and reduces fungal virulence in several models, raising the possibility that it might be developed as an antifungal agent.
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“The active form of EntV is 68 amino acids [60], which per se does not exhibit antifungal activity, inhibits C. albicans biofilm formation both in vitro and in vivo [61].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [61]
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Metadata
- Authors
- Graham, C. E., Cruz, M. R., Garsin, D. A., & Lorenz, M. C.
- Affiliations
- Department of Microbiology and Molecular Genetics, University of Texas McGovern Medical School, Houston, TX 77030;
- The University of Texas Health Science Center at Houston (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-04-10
- Volume
- 114
- Issue
- 17
- Pages
- 4507-4512
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5410809
- OpenAlex
- W2607320059
- Cited by
- 239
- References
- 66
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 21 · 2023: 25 · 2022: 25 · 2021: 32 · 2020: 32 · 2019: 27 · 2018: 24 · 2017: 8
- FWCI
- 19.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI075091, R01AI076406, R01AI110432, F31AI122725)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- Enterococcus faecalis, Candida albicans, hyphal morphogenesis, biofilm formation, fungal virulence, antifungal agents, fungal-bacterial interactions, opportunistic infections, immunocompromised patients
- MeSH terms
- RAW 264.7 Cells, Animals, Bacteriocins, Candida albicans, Candidiasis, Macrophages, Mice, Inbred BALB C, Oropharynx, Enterococcus faecalis, Virulence, Caenorhabditis elegans, Biofilms, Hyphae, Mice
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