The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans
Open accessAbstract
Significance: Hospitalized patients are susceptible to serious infections that are rarely encountered by healthy people. Two of the most problematic causes are Enterococcus faecalis and Candida albicans , a bacterium and fungus, respectively. Both are members of our normal microbial communities, but cause significant mortality in immunocompromised individuals. The formation of biofilms—microbial communities that grow on biotic or artificial surfaces—is a common feature of these infections and presents a formidable barrier to their treatment. We show here that E. faecalis produces a small protein that is a potent inhibitor of the ability of C. albicans to form biofilms and reduces fungal virulence in several models, raising the possibility that it might be developed as an antifungal agent.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The active form of EntV is 68 amino acids [60], which per se does not exhibit antifungal activity, inhibits C. albicans biofilm formation both in vitro and in vivo [61].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809
Isogenic strain construction and gene mapping in Candida albicans.
Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695
Mayr, F., Yende, S. P., & Angus, D. C. (2013) · Virulence · doi:10.4161/viru.27372 · Cited by 1,298
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., Rheinbay, E., Grabherr, M., Forche, A., Reedy, J. L., et al. (2009) · Nature · doi:10.1038/nature08064 · Cited by 1,065
Self-citationCandida albicans Biofilms and Human Disease
Nobile, C. J., & Johnson, A. D. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104330 · Cited by 1,057
Candidalysin is a fungal peptide toxin critical for mucosal infection
Moyes, D. L., Wilson, D., Richardson, J. P., Mogavero, S., Tang, S. X., Wernecke, J., Hoefs, S., Gratacap, R. L., Robbins, J., Runglall, M., et al. (2016) · Nature · doi:10.1038/nature17625 · Cited by 928
Overview of manual and automated DNA sequencing by the dideoxy chain termination method
CHEN, E., KUANG, W., & Lee, A. L. (1991) · Methods · doi:10.1016/s1046-2023(05)80158-6 · Cited by 834
Enterococci: From Commensals to Leading Causes of Drug Resistant Infection
Gilmore, M. S., Clewell, D. B., Ike, Y., & Shankar, N. (2014) · Cited by 794
Polymicrobial Interactions: Impact on Pathogenesis and Human Disease
Peters, B. M., Jabra‐Rizk, M. A., O’May, G. A., Costerton, J. W., & Shirtliff, M. E. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-11 · Cited by 733
Research works printed but not linked: 1
- 10.1111/j.1574-6968.2002.tb11330.x · DOI · Paper page
Cited by
Sorted by citations
The gut-liver axis and the intersection with the microbiome
Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480
Development and regulation of single- and multi-species Candida albicans biofilms
Lohse, M. B., Gulati, M., Johnson, A. D., & Nobile, C. J. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.107 · Cited by 643
Biofilm-associated infection by enterococci
Ch’ng, J.-H., Chong, K. K. L., Lam, L. N., Wong, J. J., & Kline, K. A. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0107-z · Cited by 459
Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier
Liu, Q., Yu, Z., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-1289-4 · Cited by 456
Richard, M. L., & Sokol, H. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0121-2 · Cited by 428
Metadata
- Authors
- Graham, C. E., Cruz, M. R., Garsin, D. A., & Lorenz, M. C.
- Affiliations
- Department of Microbiology and Molecular Genetics, University of Texas McGovern Medical School, Houston, TX 77030;
- The University of Texas Health Science Center at Houston (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-04-10
- Volume
- 114
- Issue
- 17
- Pages
- 4507-4512
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5410809
- OpenAlex
- W2607320059
- Cited by
- 239
- References
- 66
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 21 · 2023: 25 · 2022: 25 · 2021: 32 · 2020: 32 · 2019: 27 · 2018: 24 · 2017: 8
- FWCI
- 19.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI075091, R01AI076406, R01AI110432, F31AI122725)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- Enterococcus faecalis, Candida albicans, hyphal morphogenesis, biofilm formation, fungal virulence, antifungal agents, fungal-bacterial interactions, opportunistic infections, immunocompromised patients
- MeSH terms
- RAW 264.7 Cells, Animals, Bacteriocins, Candida albicans, Candidiasis, Macrophages, Mice, Inbred BALB C, Oropharynx, Enterococcus faecalis, Virulence, Caenorhabditis elegans, Biofilms, Hyphae, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
