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Myocardial aging as a T-cell–mediated phenomenon
Open accessAbstract
Significance: Aging is a risk factor for heart diseases, and it is also known to impact on several immunological processes. Nevertheless, most studies addressing the cardio-immune cross-talk have focused on juvenile rather than senescent animal models. In the present study, we addressed this gap and found that immunological activity contributes to myocardial aging. By using different lymphocyte-deficient animal models and heterochronic adoptive cell-transfer protocols, our study revealed a pivotal role for CD4 + T cells in mediating spontaneous local inflammation and mild organ dysfunction in aged hearts. These results might shed new light on the emerging field of “immunocardiology” because they reveal that spontaneous heart-directed immune responses arise even in the absence of previous myocardial tissue damage.
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“Another investigation demonstrated that the accumulation of activated memory cardiac T cells in the mediastinal lymph node and myocardium is associated with myocardial aging, leading to significantly lower cardiac output. 271,300,301”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [271]
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“Animal studies have shown that aged mice harbor a significantly higher number of α -MyHC-specific T cells within the heart and an increased number of IFNγ -producing T cells in heart-draining lymph nodes compared with young adult mice. 42,271”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [271]
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Metadata
- Authors
- Ramos, G. C., van den Berg, A., Nunes-Silva, V., Weirather, J., Peters, L., Burkard, M., Friedrich, M., Pinnecker, J., Abeßer, M., Heinze, K. G., Schuh, K., Beyersdorf, N., Kerkau, T., Demengeot, J., Frantz, S., & Hofmann, U.
- Affiliations
- Universitätsklinikum Würzburg (DE)
- Instituto Gulbenkian de Ciência, PT-2781-901 Oeiras, Portugal;
- University of Würzburg (DE)
- Instituto Gulbenkian de Ciência (PT)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-03-02
- Volume
- 114
- Issue
- 12
- Pages
- E2420-E2429
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5373357
- OpenAlex
- W2592528608
- Cited by
- 168
- References
- 61
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 21 · 2023: 19 · 2022: 23 · 2021: 19 · 2020: 27 · 2019: 12 · 2018: 13 · 2017: 8
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) (245856/2012-9)
- Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) (BMBF01 EO1004)
- Deutsche Forschungsgemeinschaft (DFG) (SFB688)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- cardiac aging, T cells, mediastinal lymph nodes, adoptive T cell therapy, cardiac function decline
- MeSH terms
- Aging, Animals, Heart, Humans, Lymph Nodes, Male, Mice, Inbred C57BL, Myocardium, CD4-Positive T-Lymphocytes, Adoptive Transfer, Mice
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