The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Myocardial aging as a T-cell–mediated phenomenon
Open accessAbstract
Significance: Aging is a risk factor for heart diseases, and it is also known to impact on several immunological processes. Nevertheless, most studies addressing the cardio-immune cross-talk have focused on juvenile rather than senescent animal models. In the present study, we addressed this gap and found that immunological activity contributes to myocardial aging. By using different lymphocyte-deficient animal models and heterochronic adoptive cell-transfer protocols, our study revealed a pivotal role for CD4 + T cells in mediating spontaneous local inflammation and mild organ dysfunction in aged hearts. These results might shed new light on the emerging field of “immunocardiology” because they reveal that spontaneous heart-directed immune responses arise even in the absence of previous myocardial tissue damage.
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“Another investigation demonstrated that the accumulation of activated memory cardiac T cells in the mediastinal lymph node and myocardium is associated with myocardial aging, leading to significantly lower cardiac output. 271,300,301”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [271]
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“Animal studies have shown that aged mice harbor a significantly higher number of α -MyHC-specific T cells within the heart and an increased number of IFNγ -producing T cells in heart-draining lymph nodes compared with young adult mice. 42,271”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [271]
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Cites
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234
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Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,199
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
Memory T Cell Subsets, Migration Patterns, and Tissue Residence
Mueller, S. N., Gebhardt, T., Carbone, F., & Heath, W. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095954 · Cited by 884
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883
Macrophages are required for neonatal heart regeneration
Aurora, A. B., Porrello, E. R., Tan, W. H., Mahmoud, A. I., Hill, J. A., Bassel‐Duby, R., Sadek, H. A., & Olson, E. N. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72181 · Cited by 840
Lavine, K. J., Epelman, S., Uchida, K., Weber, K. J., Nichols, C. G., Schilling, J. D., Ornitz, D. M., Randolph, G. J., & Mann, D. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406508111 · Cited by 818
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Cardioimmunology: the immune system in cardiac homeostasis and disease
Świrski, F. K., & Nahrendorf, M. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0065-8 · Cited by 905
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
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Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based
Fioranelli, M., Bottaccioli, A. G., Bottaccioli, F., Bianchi, M., Rovesti, M., & Roccia, M. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02031 · Cited by 302
Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration
Li, J., Tan, J. L., Martino, M. M., & Lui, K. O. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00585 · Cited by 354
Martini, E., Kunderfranco, P., Peano, C., Carullo, P., Cremonesi, M., Schorn, T., Carriero, R., Termanini, A., Colombo, F. S., Jachetti, E., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.041694 · Cited by 341
Metadata
- Authors
- Ramos, G. C., van den Berg, A., Nunes-Silva, V., Weirather, J., Peters, L., Burkard, M., Friedrich, M., Pinnecker, J., Abeßer, M., Heinze, K. G., Schuh, K., Beyersdorf, N., Kerkau, T., Demengeot, J., Frantz, S., & Hofmann, U.
- Affiliations
- Universitätsklinikum Würzburg (DE)
- Instituto Gulbenkian de Ciência, PT-2781-901 Oeiras, Portugal;
- University of Würzburg (DE)
- Instituto Gulbenkian de Ciência (PT)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-03-02
- Volume
- 114
- Issue
- 12
- Pages
- E2420-E2429
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5373357
- OpenAlex
- W2592528608
- Cited by
- 168
- References
- 61
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 21 · 2023: 19 · 2022: 23 · 2021: 19 · 2020: 27 · 2019: 12 · 2018: 13 · 2017: 8
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) (245856/2012-9)
- Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) (BMBF01 EO1004)
- Deutsche Forschungsgemeinschaft (DFG) (SFB688)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- cardiac aging, T cells, mediastinal lymph nodes, adoptive T cell therapy, cardiac function decline
- MeSH terms
- Aging, Animals, Heart, Humans, Lymph Nodes, Male, Mice, Inbred C57BL, Myocardium, CD4-Positive T-Lymphocytes, Adoptive Transfer, Mice
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