Cited by 168Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular DiseasesT-cell and B-cell Immunology

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Myocardial aging as a T-cell–mediated phenomenon

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Ramos, Gustavo Campos, van den Berg, Anne, Nunes-Silva, Vânia, Weirather, Johannes, Peters, Laura, Burkard, Matthias, Friedrich, Mike, Pinnecker, Jürgen, Abeßer, Marco, Heinze, Katrin G., Schuh, Kai, Beyersdorf, Niklas, Kerkau, Thomas, Demengeot, Jocelyne, Frantz, Stefan, Hofmann, Ulrich·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1621047114PMC PMC5373357

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Abstract

Significance: Aging is a risk factor for heart diseases, and it is also known to impact on several immunological processes. Nevertheless, most studies addressing the cardio-immune cross-talk have focused on juvenile rather than senescent animal models. In the present study, we addressed this gap and found that immunological activity contributes to myocardial aging. By using different lymphocyte-deficient animal models and heterochronic adoptive cell-transfer protocols, our study revealed a pivotal role for CD4 + T cells in mediating spontaneous local inflammation and mild organ dysfunction in aged hearts. These results might shed new light on the emerging field of “immunocardiology” because they reveal that spontaneous heart-directed immune responses arise even in the absence of previous myocardial tissue damage.

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Authors: Ramos, G. C., van den Berg, A., Nunes-Silva, V., Weirather, J., Peters, L., Burkard, M., Friedrich, M., Pinnecker, J., Abeßer, M., Heinze, K. G., Schuh, K., Beyersdorf, N., Kerkau, T., Demengeot, J., Frantz, S., & Hofmann, U.
Affiliations: Universitätsklinikum Würzburg (DE)
Instituto Gulbenkian de Ciência, PT-2781-901 Oeiras, Portugal;
University of Würzburg (DE)
Instituto Gulbenkian de Ciência (PT)
ORCID: Ramos, Gustavo Campos
Peters, Laura
Abeßer, Marco
Heinze, Katrin G.
Schuh, Kai
Beyersdorf, Niklas
Demengeot, Jocelyne
Frantz, Stefan
Hofmann, Ulrich
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-03-02
Volume: 114
Issue: 12
Pages: E2420-E2429
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1621047114
PMC: PMC5373357
OpenAlex: W2592528608
Cited by: 168
References: 61
Citations by year: 2026: 7 · 2025: 19 · 2024: 21 · 2023: 19 · 2022: 23 · 2021: 19 · 2020: 27 · 2019: 12 · 2018: 13 · 2017: 8
FWCI: 12.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 203 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Funders: Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) (245856/2012-9)
Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) (BMBF01 EO1004)
Deutsche Forschungsgemeinschaft (DFG) (SFB688)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: cardiac aging, T cells, mediastinal lymph nodes, adoptive T cell therapy, cardiac function decline
MeSH terms: Aging, Animals, Heart, Humans, Lymph Nodes, Male, Mice, Inbred C57BL, Myocardium, CD4-Positive T-Lymphocytes, Adoptive Transfer, Mice

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