Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload–Driven Heart Failure Reveals Extent of Immune Activation

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174 · see citing works

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

The Tabula Muris Consortium, coordination, O., coordination, L., processing, O. C. A., sequencing, L. P. A., analysis, C. D., annotation, C. T., Writing group, Supplemental text writing group, & Principal investigators (2018) · Nature · doi:10.1038/s41586-018-0590-4 · Cited by 3,326 · see citing works

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

Johnson, D. B., Balko, J. M., Compton, M. L., Chalkias, S., Gorham, J., Xu, Y., Hicks, M., Puzanov, I., Alexander, M. R., Bloomer, T. L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1609214 · Cited by 2,308 · see citing works

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Francisco, L. M., Salinas, V. H., Brown, K. E., Vanguri, V. K., Freeman, G. J., Kuchroo, V. K., & Sharpe, A. H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090847 · Cited by 2,072 · see citing works

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Azizi, E., Carr, A. J., Plitas, G., Cornish, A. E., Konopacki, C., Prabhakaran, S., Nainys, J., Wu, K., Kiseliovas, V., Setty, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.060 · Cited by 1,976 · see citing works

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494 · see citing works

Self-Renewing Resident Cardiac Macrophages Limit Adverse Remodeling Following Myocardial Infarction

Dick, S. A., Macklin, J. A., Nejat, S., Momen, A., Clemente-Casares, X., Althagafi, M. G., Chen, J., Kantores, C., Hosseinzadeh, S., Aronoff, L., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0272-2 · Cited by 883 · see citing works

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

Oxford IBD Cohort Investigators, West, N. R., Hegazy, A. N., Owens, B. M. J., Bullers, S. J., Linggi, B. E., Buonocore, S. M., Coccia, M., Görtz, D., This, S., et al. (2017) · Nature Medicine · doi:10.1038/nm.4307 · Cited by 814 · see citing works

The human heart contains distinct macrophage subsets with divergent origins and functions

Bajpai, G., Schneider, C., Wong, N., Bredemeyer, A., Hulsmans, M., Nahrendorf, M., Epelman, S., Kreisel, D., Liu, Y., Itoh, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0059-x · Cited by 712 · see citing works

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

Weirather, J., Hofmann, U., Beyersdorf, N., Ramos, G. C., Vogel, B., Frey, A., Ertl, G., Kerkau, T., & Frantz, S. (2014) · Circulation Research · doi:10.1161/circresaha.115.303895 · Cited by 705 · see citing works

Innate Immunity and the Failing Heart

Mann, D. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.302317 · Cited by 690 · see citing works

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

Reif, K., Ekland, E. H., Ohl, L., Nakano, H., Lipp, M., Förster, R., & Cyster, J. G. (2002) · Nature · doi:10.1038/416094a · Cited by 572 · see citing works

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

Zouggari, Y., Ait‐Oufella, H., Bonnin, P., Simon, T., Sage, A. P., Guérin, C. L., Vilar, J., Caligiuri, G., Tsiantoulas, D., Laurans, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3284 · Cited by 563 · see citing works

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

Skelly, D. A., Squiers, G. T., McLellan, M. A., Bolisetty, M. T., Robson, P., Rosenthal, N. A., & Pinto, A. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.072 · Cited by 551 · see citing works

BLC Expression in Pancreatic Islets Causes B Cell Recruitment and Lymphotoxin-Dependent Lymphoid Neogenesis

Luther, S. A., Lopez, T., Bai, W., Hanahan, D., & Cyster, J. G. (2000) · Immunity · doi:10.1016/s1074-7613(00)80199-5 · Cited by 468 · see citing works

Interleukin 6 Mediates Myocardial Fibrosis, Concentric Hypertrophy, and Diastolic Dysfunction in Rats

Meléndez, G. C., McLarty, J. L., Levick, S. P., Du, Y., Janicki, J. S., & Brower, G. L. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.148635 · Cited by 441 · see citing works

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

Bonavita, E., Gentile, S., Rubino, M., Maina, V., Papait, R., Kunderfranco, P., Greco, C. M., Feruglio, F., Molgora, M., Laface, I., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.004 · Cited by 417 · see citing works

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE −/− mice

Gräbner, R., Lötzer, K., Döpping, S., Hildner, M., Radke, D., Beer, M., Spanbroek, R., Lippert, B., Reardon, C. A., Getz, G. S., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20080752 · Cited by 398 · see citing works

Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling

Kubin, T., Pöling, J., Sawa Kostin, D., Gajawada, P., Hein, S., Rees, W., Wietelmann, A., Tanaka, M., Lörchner, H., Schimanski, S., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.08.013 · Cited by 355 · see citing works

Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Cytoskeleton-Associated Protein 4 as a New Modulator of Fibroblasts Activation

Gladka, M. M., Molenaar, B., de Ruiter, H., van der Elst, S., Tsui, H., Versteeg, D., Lacraz, G., Huibers, M. M. H., van Oudenaarden, A., & van Rooij, E. (2018) · Circulation · doi:10.1161/circulationaha.117.030742 · Cited by 312 · see citing works

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

Bansal, S. S., Ismahil, M. A., Goel, M., Zhou, G., Rokosh, G. D., Hamid, T., & Prabhu, S. D. (2019) · Circulation · doi:10.1161/circulationaha.118.036065 · Cited by 303 · see citing works

CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload

Patel, B., Bansal, S. S., Ismahil, M. A., Hamid, T., Rokosh, G., Mack, M., & Prabhu, S. D. (2018) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2017.12.006 · Cited by 297 · see citing works

CD4 + T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload

Laroumanie, F., Douin‐Echinard, V., Pozzo, J., Lairez, O., Tortosa, F., Vinel, C., Delage, C., Calise, D., Dutaur, M., Parini, A., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.007101 · Cited by 294 · see citing works

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure

Nevers, T. A., Salvador, A. M., Grodecki‐Pena, A., Knapp, A., Velázquez, F., Aronovitz, M. J., Kapur, N. K., Karas, R. H., Blanton, R. M., & Alcaide, P. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002225 · Cited by 272 · see citing works

Once a Treg, always a Treg?

Sawant, D. V., & Vignali, D. A. A. (2014) · Immunological Reviews · doi:10.1111/imr.12173 · Cited by 248 · see citing works

Stem Cell Factor in Mast Cells and Increased Mast Cell Density in Idiopathic and Ischemic Cardiomyopathy

Patella, V., Marinò, I., Arbustini, E., Lamparter, B., Verga, L., Adt, M., & Marone, G. (1998) · Circulation · doi:10.1161/01.cir.97.10.971 · Cited by 246 · see citing works

The epigenetic control of stemness in CD8 + T cell fate commitment

Pace, L., Goudot, C., Zueva, E., Gueguen, P., Burgdorf, N., Waterfall, J. J., Quivy, J., Almouzni, G., & Amigorena, S. (2018) · Science · doi:10.1126/science.aah6499 · Cited by 236 · see citing works

T cell costimulation blockade blunts pressure overload-induced heart failure

Kallikourdis, M., Martini, E., Carullo, P., Sardi, C., Roselli, G., Greco, C. M., Vignali, D., Riva, F., Berre, A. M. O., Stølen, T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14680 · Cited by 203 · see citing works

Infarcted Myocardium-Primed Dendritic Cells Improve Remodeling and Cardiac Function After Myocardial Infarction by Modulating the Regulatory T Cell and Macrophage Polarization

Choo, E., Lee, J.-H., Park, E., Park, H., Jung, N.-C., Kim, T., Koh, Y., Kim, E., Seung, K., Park, C., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.023106 · Cited by 173 · see citing works

Myocardial aging as a T-cell–mediated phenomenon

Ramos, G. C., van den Berg, A., Nunes-Silva, V., Weirather, J., Peters, L., Burkard, M., Friedrich, M., Pinnecker, J., Abeßer, M., Heinze, K. G., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621047114 · Cited by 168 · see citing works

Increased Expression of Interleukin-1β and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload

Shioi, T., Matsumori, A., Kihara, Y., Inoko, M., Ono, K., Iwanaga, Y., Yamada, T., Iwasaki, A., Matsushima, K., & Sasayama, S. (1997) · Circulation Research · doi:10.1161/01.res.81.5.664 · Cited by 162 · see citing works

Increased Expression of Interleukin-1β and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload

TetsuoShioi, AkiraMatsumori, YasukiKihara, MoriakiInoko, KohOno, YoshitakaIwanaga, TakehikoYamada, AtsushiIwasaki, KoujiMatsushima, & ShigetakeSasayama (1997) · Circulation Research · Cited by 162 · see citing works

Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure

Dirkx, E., Gladka, M. M., Philippen, L. E., Armand, A., Kinet, V., Leptidis, S., el Azzouzi, H., Salic, K., Bourajjaj, M., da Silva, G. J. J., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2866 · Cited by 133 · see citing works

Mast Cells Cause Apoptosis of Cardiomyocytes and Proliferation of Other Intramyocardial Cells In Vitro

Hara, M., Matsumori, A., Ono, K., Kido, H., Hwang, M., Miyamoto, T., Iwasaki, A., Okada, M., Nakatani, K., & Sasayama, S. (1999) · Circulation · doi:10.1161/01.cir.100.13.1443 · Cited by 117 · see citing works

Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release

Komarowska, I., Coe, D., Wang, G., Haas, R., Mauro, C., Kishore, M., Cooper, D., Nadkarni, S., Fu, H., Steinbrüchel, D. A., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.014 · Cited by 105 · see citing works

Natural killer cells in inflammatory heart disease

Ong, S., Rose, N. R., & Čiháková, D. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.11.010 · Cited by 105 · see citing works

Full Expression of Cardiomyopathy Is Partly Dependent on B‐Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis

Cordero‐Reyes, A. M., Youker, K. A., Trevino, A. R., Celis, R., Hamilton, D. J., Flores‐Arredondo, J. H., Orrego, C. M., Bhimaraj, A., Estep, J. D., & Torre‐Amione, G. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002484 · Cited by 103 · see citing works

SECRETION OF IL-6, IL-11 AND LIF BY HUMAN CARDIOMYOCYTES IN PRIMARY CULTURE

Ancey, C., Corbi, P., Froger, J., Delwail, A., Wijdenes, J., Gascan, H., Potreau, D., & Lecron, J. (2002) · Cytokine · doi:10.1006/cyto.2002.1033 · Cited by 99 · see citing works

Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy

Diny, N. L., Baldeviano, G. C., Talor, M. V., Barin, J. G., Ong, S., Bedja, D., Hays, A. G., Gilotra, N. A., Coppens, I., Rose, N. R., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161702 · Cited by 99 · see citing works

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

Massara, M., Bonavita, O., Savino, B., Caronni, N., Poeta, V. M., Sironi, M., Setten, E., Recordati, C., Crisafulli, L., Ficara, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03080-8 · Cited by 98 · see citing works

ORIGINAL ARTICLE: PD‐1 but not CTLA‐4 Blockage Abrogates the Protective Effect of Regulatory T Cells in a Pregnancy Murine Model

Wafula, P. O., Teles, A., Schumacher, A., Pohl, K., Yagita∥, H., Volk, H., & Zenclussen, A. C. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2009.00737.x · Cited by 80 · see citing works

Mechanisms of T cell organotropism

Fu, H., Ward, E. J., & Marelli‐Berg, F. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2211-4 · Cited by 73 · see citing works

Induction of CD69 activation molecule on human neutrophils by GM-CSF, IFN-γ, and IFN-α

Atzeni, F., Schena, M., Ongari, A. M., Carrabba, M., Bonara, P., Minonzio, F., & CAPSONI, F. (2002) · Cellular Immunology · doi:10.1016/s0008-8749(03)00002-9 · Cited by 60 · see citing works

Improving homing in T cell therapy

Vignali, D., & Kallikourdis, M. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.06.009 · Cited by 51 · see citing works

Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells

der Borght, K. V., Scott, C. L., Martens, L., Sichien, D., Isterdael, G. V., Nindl, V., Saeys, Y., Boon, L., Ludewig, B., Gillebert, T. C., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02714 · Cited by 44 · see citing works

Antibodies aggravate the development of ischemic heart failure

Keppner, L., Heinrichs, M., Rieckmann, M., Demengeot, J., Frantz, S., Hofmann, U., & Ramos, G. C. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00144.2018 · Cited by 40 · see citing works

CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure

Gröschel, C., Sasse, A., Monecke, S., Röhrborn, C., Elsner, L., Didié, M., Reupke, V., Bunt, G., Lichtman, A. H., Toischer, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02665 · Cited by 29 · see citing works

Peak inflammation in atherosclerosis, primary biliary cirrhosis and autoimmune arthritis is counter-intuitively associated with regulatory T cell enrichment

Garetto, S., Trovato, A. E., Lleò, A., Sala, F., Martini, E., Betz, A. G., Norata, G. D., Invernizzi, P., & Kallikourdis, M. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.02.006 · Cited by 24 · see citing works

CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

Roselli, G., Martini, E., Lougaris, V., Badolato, R., Viola, A., & Kallikourdis, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01068 · Cited by 20 · see citing works

Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease

Martini, E., Giugliano, S., Rescigno, M., & Kallikourdis, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00509 · Cited by 14 · see citing works

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

Tschöpe, C., Ammirati, E., Bozkurt, B., Caforio, A. L. P., Cooper, L. T., Felix, S. B., Hare, J. M., Heidecker, B., Heymans, S., Hübner, N., et al. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00435-x · Cited by 1,217 · see citing works

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Koenig, A. L., Shchukina, I., Amrute, J., Andhey, P. S., Zaitsev, K., Lai, L., Bajpai, G., Bredemeyer, A., Smith, G., Jones, C., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00028-6 · Cited by 482 · see citing works

T cells specific for α-myosin drive immunotherapy-related myocarditis

Axelrod, M. L., Meijers, W. C., Screever, E. M., Qin, J., Carroll, M. G., Sun, X., Tannous, E., Zhang, Y., Sugiura, A., Taylor, B. C., et al. (2022) · Nature · doi:10.1038/s41586-022-05432-3 · Cited by 367 · see citing works

Single-cell RNA sequencing in cardiovascular development, disease and medicine

Paik, D. T., Cho, S., Tian, L., Chang, H. Y., & Wu, J. C. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0359-y · Cited by 306 · see citing works

Targeting immune–fibroblast cell communication in heart failure

Amrute, J. M., Luo, X., Penna, V., Yang, S., Yamawaki, T., Hayat, S., Bredemeyer, A., Jung, I.-H., Kadyrov, F. F., Heo, G. S., et al. (2024) · Nature · doi:10.1038/s41586-024-08008-5 · Cited by 298 · see citing works

Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis

Revelo, X. S., Parthiban, P., Chen, C., Barrow, F., Fredrickson, G., Wang, H., Yücel, D., Herman, A., & van Berlo, J. H. (2021) · Circulation Research · doi:10.1161/circresaha.121.319737 · Cited by 298 · see citing works

Unraveling B cell trajectories at single cell resolution

Morgan, D., & Tergaonkar, V. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.01.003 · Cited by 232 · see citing works

TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis

Zhang, K., Wang, Y., Chen, S., Mao, J., Jin, Y., Ye, H., Zhang, Y., Liu, X., Gong, C., Cheng, X., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-022-00715-5 · Cited by 223 · see citing works

Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution

Wang, Z., Cui, M., Shah, A. M., Tan, W. H., Liu, N., Bassel‐Duby, R., & Olson, E. N. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108472 · Cited by 170 · see citing works

Identification and characterization of neutrophil heterogeneity in sepsis

Qi, X., Yu, Y., Sun, R., Huang, J., Liu, L., Yang, Y., Tao, R., & Sun, B. (2021) · Critical Care · doi:10.1186/s13054-021-03481-0 · Cited by 173 · see citing works

Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis

Ko, T., Nomura, S., Yamada, S., Fujita, K., Fujita, T., Satoh, M., Oka, C., Katoh, M., Ito, M., Katagiri, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30630-y · Cited by 155 · see citing works

Electroimmunology and cardiac arrhythmia

Grune, J., Yamazoe, M., & Nahrendorf, M. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00520-9 · Cited by 152 · see citing works

Resident cardiac macrophages: Heterogeneity and function in health and disease

Zaman, R., & Epelman, S. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.009 · Cited by 141 · see citing works

ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice

Zhuang, T., Chen, M., Wu, R.-X., Wang, J., Hu, X.-D., Meng, T., Wu, A.-H., Li, Y., Yang, Y., Lei, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46357-x · Cited by 141 · see citing works

Immunometabolic mechanisms of heart failure with preserved ejection fraction

Schiattarella, G. G., Alcaide, P., Condorelli, G., Gillette, T. G., Heymans, S. R. B., Jones, E. A. V., Kallikourdis, M., Lichtman, A. H., Marelli‐Berg, F. M., Shah, S. J., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00032-w · Cited by 131 · see citing works

Single‐Cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction

Jin, K., Gao, S., Yang, P., Guo, R., Li, D., Zhang, Y., Lu, X., Fan, G., & Fan, X. (2022) · Small Methods · doi:10.1002/smtd.202100752 · Cited by 133 · see citing works

Epigenetics of aging and disease: a brief overview

Pagiatakis, C., Musolino, E., Gornati, R., Bernardini, G., & Papait, R. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01430-0 · Cited by 129 · see citing works

The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications

Wang, X., Chen, L., Wei, J., Zheng, H., Zhou, N., Xu, X., Deng, X., Liu, T., & Zou, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02220-z · Cited by 120 · see citing works

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Feijóo‐Bandín, S., Aragón‐Herrera, A., Moraña‐Fernández, S., Anido‐Varela, L., Tarazón, E., Roselló‐Lletí, E., Portolés, M., Moscoso, I., Gualillo, O., González‐Juanatey, J. R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207711 · Cited by 123 · see citing works

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis

Sebastian, A., Hum, N. R., McCool, J. L., Wilson, S. P., Murugesh, D. K., Martin, K. A., Rios‐Arce, N. D., Amiri, B., Christiansen, B., & Loots, G. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.938075 · Cited by 110 · see citing works

Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection

Liu, X., Chen, W., Zhu, G., Yang, H., Li, W., Luo, M., Shu, C., & Zhou, Z. (2022) · Cell Discovery · doi:10.1038/s41421-021-00362-2 · Cited by 106 · see citing works

Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury

Gao, L., Zhao, Y., Wu, H., Lin, X.-H., Guo, F., Li, J., Long, Y., Zhou, B., She, J., Zhang, C., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.065827 · Cited by 106 · see citing works

Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart

Forte, E., Perkins, B., Sintou, A., Kalkat, H., Papanikolaou, A., Jenkins, C., Alsubaie, M., Chowdhury, R. A., Duffy, T. M., Skelly, D. A., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.044581 · Cited by 98 · see citing works

SiglecF(HI) Marks Late‐Stage Neutrophils of the Infarcted Heart: A Single‐Cell Transcriptomic Analysis of Neutrophil Diversification

Calcagno, D. M., Zhang, C., Toomu, A., Huang, K., Ninh, V. K., Miyamoto, S., Aguirre, A. D., Fu, Z., Brown, J. H., & King, K. R. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019019 · Cited by 98 · see citing works

SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)–Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation

Tang, X., Pan, L., Zhao, S., Dai, F., Chao, M., Jiang, H., Li, X., Lin, Z., Huang, Z., Meng, G., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.042336 · Cited by 96 · see citing works

Metabolism and Chronic Inflammation: The Links Between Chronic Heart Failure and Comorbidities

Li, Z., Zhao, H., & Wang, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650278 · Cited by 98 · see citing works

Cardiac Mast Cells: Underappreciated Immune Cells in Cardiovascular Homeostasis and Disease

Varricchi, G., Marone, G., & Kovanen, P. T. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.06.006 · Cited by 90 · see citing works

Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy

Suffee, N., Moore‐Morris, T., Jagla, B., Mougenot, N., Dilanian, G., Berthet, M., Proukhnitzky, J., Leprince, P. N., Trégouët, D., Pucéat, M., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316251 · Cited by 88 · see citing works

iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway

Guo, Y., You, Y., Shang, F., Wang, X., Huang, B., Zhao, B., Lv, D., Yang, S., Xie, M., Kong, L., et al. (2023) · Theranostics · doi:10.7150/thno.84049 · Cited by 88 · see citing works

CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Affandi, A. J., Carvalheiro, T., Ottria, A., de Haan, J. J., Brans, M. A. D., Brandt, M. M., Tieland, R. G., Lopes, A. P., Malvar‐Fernández, B., Bekker, C. P. J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110189 · Cited by 86 · see citing works

Single-cell and spatial transcriptomics of the infarcted heart define the dynamic onset of the border zone in response to mechanical destabilization

Calcagno, D. M., Taghdiri, N., Ninh, V. K., Mesfin, J. M., Toomu, A., Sehgal, R., Lee, J., Liang, Y., Duran, J. M., Adler, E., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00160-3 · Cited by 84 · see citing works

Single-cell RNA-sequencing reveals profound changes in circulating immune cells in patients with heart failure

Abplanalp, W. T., John, D., Cremer, S., Aßmus, B., Dorsheimer, L., Hoffmann, J., Becker‐Pergola, G., Rieger, M. A., Zeiher, A. M., Vasa‐Nicotera, M., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa101 · Cited by 82 · see citing works

Myocardial Inflammation in Heart Failure With Reduced and Preserved Ejection Fraction

Alcaide, P., Kallikourdis, M., Emig, R., & Prabhu, S. D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323659 · Cited by 84 · see citing works

Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart

Radmand, A., Kim, H., Beyersdorf, J. P., Dobrowolski, C. N., Zenhausern, R., Paunovska, K., Huayamares, S. G., Hua, X., Han, K., Loughrey, D., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2307801120 · Cited by 81 · see citing works

Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies

Steffens, S., Nahrendorf, M., & Madonna, R. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab842 · Cited by 77 · see citing works

Tissue-resident immune cells: from defining characteristics to roles in diseases

Li, J., Chu, X., Li, C., & He, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02050-5 · Cited by 80 · see citing works

Regulatory T Cells in Chronic Heart Failure

Lu, Y., Xia, N., & Cheng, X. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.732794 · Cited by 72 · see citing works

Myeloid-Derived Growth Factor Protects Against Pressure Overload–Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca ²⁺ -ATPase Expression in Cardiomyocytes

Korf-Klingebiel, M., Reboll, M. R., Polten, F., Weber, N., Jäckle, F., Wu, X., Kallikourdis, M., Kunderfranco, P., Condorelli, G., Giannitsis, E., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.053365 · Cited by 71 · see citing works

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

Panico, C., Felicetta, A., Kunderfranco, P., Cremonesi, M., Salvarani, N., Carullo, P., Colombo, F., Idini, A., Passaretti, M., Doro, R., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.062984 · Cited by 70 · see citing works

Adding insult to injury - Inflammation at the heart of cardiac fibrosis

Smolgovsky, S. A., Ibeh, U., Tamayo, T. P., & Alcaide, P. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109828 · Cited by 70 · see citing works

Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure

Li, H., Chen, C., & Wang, D. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.695047 · Cited by 72 · see citing works

Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation

Chen, J., Norling, L. V., & Cooper, D. (2021) · Cells · doi:10.3390/cells10040881 · Cited by 69 · see citing works

Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure

Heron, C., Dumesnil, A., Houssari, M., Renet, S., Lemarcis, T., Lebon, A., Godefroy, D., Schapman, D., Henri, O., Riou, G., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac086 · Cited by 66 · see citing works

Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells

Wang, J., Liu, S., Meng, X., Zhao, X., Wang, T., Lei, Z., Lehmann, H. I., Li, G., Alcaide, P., Bei, Y., et al. (2024) · Circulation Research · doi:10.1161/circresaha.123.323346 · Cited by 66 · see citing works

Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2‐Mediated Suppression of NLRP3 Inflammasome Activation

Sun, X., Duan, J., Gong, C., Feng, Y., Hu, J., Gu, R., & Xu, B. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025266 · Cited by 67 · see citing works

Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction

Yamada, S., Ko, T., Hatsuse, S., Nomura, S., Zhang, B., Dai, Z., Inoue, S., Kubota, M., Sawami, K., Yamada, T., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00140-7 · Cited by 66 · see citing works

Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium

Zaman, R., Hamidzada, H., & Epelman, S. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.09.005 · Cited by 65 · see citing works

Immunometabolism in heart failure

Andreadou, I., Ghigo, A., Nikolaou, P., Świrski, F. K., Thackeray, J. T., Heusch, G., & Vilahur, G. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01165-8 · Cited by 69 · see citing works

Functional diversity of cardiac macrophages in health and disease

Yang, S. H., Penna, V. R., & Lavine, K. J. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01109-8 · Cited by 63 · see citing works

Atrial fibrillation in COVID‐19: A review of possible mechanisms

Stone, E., Kiat, H., & McLachlan, C. S. (2020) · The FASEB Journal · doi:10.1096/fj.202001613 · Cited by 61 · see citing works

Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function

Ciccarelli, M., Dawson, D. K., Falcão‐Pires, I., Giacca, M., Hamdani, N., Heymans, S. R. B., Hooghiemstra, A. M., Leeuwis, A. E., Hermkens, D. M. A., Tocchetti, C. G., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab009 · Cited by 61 · see citing works

Early Protective Role of Inflammation in Cardiac Remodeling and Heart Failure: Focus on TNFα and Resident Macrophages

BESSE, S., Nadaud, S., Balse, E., & Pavoine, C. (2022) · Cells · doi:10.3390/cells11071249 · Cited by 60 · see citing works

The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism

Heinrichs, M., Ashour, D., Siegel, J., Büchner, L., Wedekind, G., Heinze, K. G., Arampatzi, P., Saliba, A., Cochain, C., Hofmann, U., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab181 · Cited by 58 · see citing works

Adult T-cells impair neonatal cardiac regeneration

Dolejsi, T., Delgobo, M., Schuetz, T., Tortola, L., Heinze, K. G., Hofmann, U., Frantz, S., Bauer, A., Ruschitzka, F., Penninger, J. M., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac153 · Cited by 53 · see citing works

Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure

Smart, C. D., Fehrenbach, D. J., Wassenaar, J. W., Agrawal, V., Fortune, N. L., Dixon, D., Cottam, M. A., Hasty, A. H., Hemnes, A. R., Doran, A. C., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad093 · Cited by 52 · see citing works

Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure

Gergely, T. G., Drobni, Z. D., Kallikourdis, M., Zhu, H., Meijers, W. C., Neilan, T. G., Rassaf, T., Ferdinandy, P., & Varga, Z. V. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00986-9 · Cited by 52 · see citing works

Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling

Liu, X., Shi, G., & Guo, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.659666 · Cited by 51 · see citing works

Global Characteristics and Dynamics of Single Immune Cells After Myocardial Infarction

Zhuang, L., Wang, Y., Chen, Z., Li, Z., Wang, Z., Jia, K., Zhao, J., Zhang, H., Xie, H., Lu, L., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.027228 · Cited by 51 · see citing works

Multi-omics profiling visualizes dynamics of cardiac development and functions

Gu, Y., Zhou, Y., Ju, S., Liu, X., Zhang, Z., Guo, J., Gao, J., Zang, J., Sun, H., Chen, Q., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111891 · Cited by 49 · see citing works

Mast cells: a novel therapeutic avenue for cardiovascular diseases?

Poto, R., Marone, G., Galli, S. J., & Varricchi, G. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae066 · Cited by 54 · see citing works

Fibroblasts and immune cells: at the crossroad of organ inflammation and fibrosis

Smolgovsky, S. A., Theall, B. P., Wagner, N., & Alcaide, P. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00545.2023 · Cited by 49 · see citing works

The complexity of neutrophils in health and disease: Focus on cancer

Carnevale, S., Ghasemi, S., Rigatelli, A., & Jaillon, S. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101409 · Cited by 49 · see citing works

Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart

Forte, E., Panahi, M., Baxan, N., Ng, F. S., Boyle, J. J., Branca, J. A., Bedard, O., Hasham, M. G., Benson, L., Harding, S. E., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15937 · Cited by 49 · see citing works

Heart failure promotes multimorbidity through innate immune memory

Nakayama, Y., Fujiu, K., Oshima, T., Matsuda, J., Sugita, J., Matsubara, T. J., Liu, Y., Goto, K., Kani, K., Uchida, R., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.ade3814 · Cited by 48 · see citing works

Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics

Palmer, J. A., Rosenthal, N. A., Teichmann, S. A., & Litviňuková, M. (2024) · Circulation Research · doi:10.1161/circresaha.124.323672 · Cited by 48 · see citing works

Understanding mast cell heterogeneity at single cell resolution

Cildir, G., Yip, K. H., Pant, H., Tergaonkar, V., Lopez, A. F., & Tumes, D. J. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.04.004 · Cited by 46 · see citing works

Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling

Ye, S., Huang, H., Han, X., Luo, W., Wu, L., Ye, Y., Gong, Y., Zhao, X., Huang, W., Wang, Y., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322259 · Cited by 46 · see citing works

Single-cell genomics to understand disease pathogenesis

Nomura, S. (2020) · Journal of Human Genetics · doi:10.1038/s10038-020-00844-3 · Cited by 44 · see citing works

Dissecting the cellular landscape and transcriptome network in viral myocarditis by single-cell RNA sequencing

(2022) · doi:10.1016/j.isci.2022.103865 · Cited by 43 · see citing works

Dissecting the transcriptome in cardiovascular disease

Robinson, E. L., Baker, A. H., Brittan, M., McCracken, I. R., Condorelli, G., Emanueli, C., Srivastava, P. K., Gaetano, C., Thum, T., Vanhaverbeke, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab117 · Cited by 43 · see citing works

Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure

Yerra, V. G., Batchu, S. N., Kaur, H., Kabir, M. G., Liu, Y., Advani, S. L., Tran, D. T., Sadeghian, S., Sedrak, P., Billia, F., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci161453 · Cited by 42 · see citing works

Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing

Chen, B., Zhu, L., Yang, S., & Su, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.711329 · Cited by 41 · see citing works

Phenylacetylglutamine as a Risk Factor and Prognostic Indicator of Heart Failure

Zong, X., Fan, Q., Yang, Q., Pan, R., Zhuang, L., & Tao, R. (2022) · ESC Heart Failure · doi:10.1002/ehf2.13989 · Cited by 42 · see citing works

CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure

Zhang, Y., Ye, Y., Tang, X., Wang, H., Tanaka, T., Tian, R., Yang, X., Wang, L., Xiao, Y., Hu, X., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20200418 · Cited by 41 · see citing works

Distinctive patterns of inflammation across the heart failure syndrome

Schiattarella, G. G., Sequeira, V., & Ameri, P. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-09949-5 · Cited by 43 · see citing works

Immune cell β2-adrenergic receptors contribute to the development of heart failure

Tanner, M. A., Maitz, C. A., & Grisanti, L. A. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00243.2021 · Cited by 39 · see citing works

Single-cell technologies to decipher cardiovascular diseases

Abplanalp, W. T., Tucker, N. R., & Dimmeler, S. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac095 · Cited by 40 · see citing works

Targeting regulatory T cells for cardiovascular diseases

Wang, X., Zhou, H., Liu, Q., Cheng, P., Zhao, T., Yang, T., Zhao, Y., Sha, W., Zhao, Y., & Qu, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126761 · Cited by 37 · see citing works

Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside

Xu, X., Hua, X., Han, M., Hu, S., & Song, J. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-022-00972-1 · Cited by 37 · see citing works

Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity

Liu, Y., Zou, L., Tang, H., Li, J., Liu, H., Jiang, X., Jiang, B., Dong, Z., & Fu, W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.791875 · Cited by 36 · see citing works

Single-cell and spatial transcriptomics: Advances in heart development and disease applications

Long, X., Yuan, X., & Du, J. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.04.007 · Cited by 37 · see citing works

GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism

Ji, T., Liu, Q., Yu, L., Lei, W., Lu, C., Chen, J., Xie, X., Zhang, Z., Liang, Z., Deng, C., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.007 · Cited by 34 · see citing works

The Roles of Macrophages in Heart Regeneration and Repair After Injury

Gao, Y., Qian, N., Xu, J., & Wang, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.744615 · Cited by 33 · see citing works

Cellular Heterogeneity of the Heart

Michel, N. A., Ljubojević-Holzer, S., Bugger, H., & Zirlik, A. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.868466 · Cited by 40 · see citing works

Cardiac Macrophages and Their Effects on Arrhythmogenesis

Xia, R., Tomsits, P., Loy, S., Zhang, Z., Pauly, V., Schüttler, D., & Clauß, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.900094 · Cited by 31 · see citing works

T-Cell MyD88 Is a Novel Regulator of Cardiac Fibrosis Through Modulation of T-Cell Activation

Bayer, A. L., Smolgovsky, S. A., Ngwenyama, N., Hernández-Martínez, A., Kaur, K., Sulka, K. B., Amrute, J., Aronovitz, M. J., Lavine, K. J., Sharma, S., et al. (2023) · Circulation Research · doi:10.1161/circresaha.123.323030 · Cited by 33 · see citing works

Early microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin

Efentakis, P., Choustoulaki, A., Kwiatkowski, G., Varela, A., Kostopoulos, I. V., Tsekenis, G., Ntanasis‐Stathopoulos, I., Georgoulis, A., Vorgias, C. E., Gakiopoulou, H., et al. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01046-0 · Cited by 32 · see citing works

Aberrant branched-chain amino acid catabolism in cardiovascular diseases

Xiong, Y., Jiang, L., & Li, T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.965899 · Cited by 32 · see citing works

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Boyett, M. R., Yanni, J., Tellez, J. O., Bucchi, A., Mesirca, P., Cai, X., Logantha, S. J. R. J., Wilson, C., Anderson, C., Ariyaratnam, J., et al. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.06.008 · Cited by 31 · see citing works

Single-Cell RNA Sequencing Reveals the Immunological Profiles of Renal Allograft Rejection in Mice

Shen, Q., Wang, Y., Chen, J., Ma, L., Huang, X., Tang, S. C. W., Lan, H., Jiang, H., & Chen, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.693608 · Cited by 31 · see citing works

Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling

Yerra, V. G., & Advani, A. (2022) · Biomedicines · doi:10.3390/biomedicines10030661 · Cited by 32 · see citing works

Single-cell RNA Sequencing (scRNA-seq): Advances and Challenges for Cardiovascular Diseases (CVDs)

Khan, S. U., Huang, Y., Ali, H., Ali, I., Ahmad, S., Khan, S. U., Hussain, T., Ullah, M., & Lu, K. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102202 · Cited by 31 · see citing works

Comprehensive Integration of Single-Cell Transcriptional Profiling Reveals the Heterogeneities of Non-cardiomyocytes in Healthy and Ischemic Hearts

Zhuang, L., Lu, L., Zhang, R., Chen, K., & Yan, X. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.615161 · Cited by 29 · see citing works

Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure

Sasset, L., Manzo, O. L., Zhang, Y., Marino, A., Rubinelli, L., Riemma, M. A., Chalasani, M. L. S., Dasoveanu, D., Roviezzo, F., Jankauskas, S. S., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac108 · Cited by 30 · see citing works

Large animal models of pressure overload-induced cardiac left ventricular hypertrophy to study remodelling of the human heart with aortic stenosis

Beslika, E., Leite-Moreira, A. F., Windt, L. J. D., & Martins, P. A. D. C. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae045 · Cited by 30 · see citing works

Integrative Analysis of Bulk and Single-Cell RNA Sequencing Data Reveals Cell Types Involved in Heart Failure

Shi, X., Zhang, L., Li, Y., Xue, J., Liang, F., Ni, H.-W., Wang, X., Cai, Z., Shen, L.-H., Huang, T., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.779225 · Cited by 29 · see citing works

Single-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repair

Fu, M., Jia, S., Xu, L., Li, X., Lv, Y., Zhong, Y., & Ai, S. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175297 · Cited by 30 · see citing works

Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure

Du, L., Sun, X., Gong, H., Wang, T. Z., Jiang, L., Huang, C., Xu, X., Li, Z., Xu, H., Ma, L., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03256-0 · Cited by 28 · see citing works

Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction

Zelko, I. N., Dassanayaka, S., Malovichko, M. V., Howard, C. M., Garrett, L. F., Uchida, S., Brittian, K. R., Conklin, D. J., Jones, S. P., & Srivastava, S. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab125 · Cited by 27 · see citing works

A cardioimmunologist’s toolkit: genetic tools to dissect immune cells in cardiac disease

Wong, A., Hamidzada, H., & Epelman, S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00701-0 · Cited by 26 · see citing works

Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling

Liu, X., Shi, G., & Guo, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.659666 · Cited by 51 · see citing works

Abstract 171: T Cell Mediated Immune Responses Regulate Cardiac Remodeling and Survival in Pressure Overload Induced Heart Failure

Alcaide, P., Nevers, T. A., Salvador, A. M., Grodecki‐Pena, A., Knapp, A., Aronovitz, M. J., Velazquez, F., Kershaw, T., Kapur, N. K., Blanton, R. M., et al. (2014) · Circulation Research · doi:10.1161/res.115.suppl_1.171

Human, mouse scRNA-seq and flow cytometry data in ischemic heart failure models predict immune cell activation signatures with altered endothelial cell cross talk

Merten, M., Rasper, T., Cremer, S., Schuhmacher, B., Tombor, L., Zeiher, A. M., Hoffmann, J., Abplanalp, W. T., & Dimmeler, S. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac544.2965

T Cells Control Cardiac Remodeling in Pressure Overload Induced Heart Failure

Nevers, T. A., Salvador, A. M., Grodecki‐Pena, A., Knapp, A., Velazquez, F., Aronovitz, M. J., Kershaw, T., Blanton, R. M., Kapur, N. K., Karas, R. H., et al. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.46.5

Abstract 18244: Macrophages Infiltrate the Heart With Activation of Adaptive Immunity During Compensated Pressure Overload Hypertrophy

Patel, B., Ismahil, M. A., Bansal, S. S., Michaud, A. M., & Prabhu, S. D. (2015) · Circulation · doi:10.1161/circ.132.suppl_3.18244