The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mechanism of H 2 S-mediated protection against oxidative stress in Escherichia coli
Open accessAbstract
Significance: Hydrogen sulfide (H 2 S) is a highly toxic gas that interferes with cellular respiration; however, at low physiological amounts, it plays an important role in cell signaling. Remarkably, in bacteria, endogenously produced H 2 S has been recently recognized as a general protective molecule, which renders multiple bacterial species highly resistant to oxidative stress and various classes of antibiotics. The mechanism of this phenomenon remains poorly understood. In this paper, we use Escherichia coli as a model system to elucidate its major enzymatic source of H 2 S and establish the principle biochemical pathways that account for H 2 S-mediated protection against reactive oxygen species. Understanding those mechanisms has far-reaching implications in preventing bacterial resistance and designing effective antimicrobial therapies.
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Cites
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science · doi:10.1126/science.2834821 · Cited by 1,555 · cited 1×
“These DSBs are the result of the toxic effects of the hydroxyl radical generated by the Fenton reaction (24).”
BackgroundIron and metal regulation in bacteria
Hantke, K. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00184-3 · Cited by 755
Cited by
Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace
Chinemerem Nwobodo, D., Ugwu, M. C., Oliseloke Anie, C., Al‐Ouqaili, M. T. S., Chinedu Ikem, J., Victor Chigozie, U., & Saki, M. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24655 · Cited by 985
Post-stress bacterial cell death mediated by reactive oxygen species
Hong, Y., Zeng, J., Wang, X., Drlica, K., & Zhao, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901730116 · Cited by 513
Pedre, B., Barayeu, U., Ezeriņa, D., & Dick, T. P. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107916 · Cited by 470
Hydrogen sulfide: An endogenous regulator of the immune system
Dilek, N., Papapetropoulos, A., Toliver-Kinsky, T., & Szabo, C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105119 · Cited by 292
Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance
Shatalin, K., Nuthanakanti, A., Kaushik, A., Shishov, D., Peselis, A., Shamovsky, I., Pani, B., Lechpammer, M., Vasilyev, N., Shatalina, E., et al. (2021) · Science · doi:10.1126/science.abd8377 · Cited by 259
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Metadata
- Authors
- Mironov, A., Seregina, T., Nagornykh, M., Luhachack, L. G., Korolkova, N., Lopes, L. E., Kotova, V., Zavilgelsky, G., Shakulov, R., Shatalin, K., & Nudler, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-05-22
- Volume
- 114
- Issue
- 23
- Pages
- 6022-6027
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2619253163
- Cited by
- 224
- References
- 3
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mironov, A., Seregina, T., Nagornykh, M., Luhachack, L. G., Korolkova, N., Lopes, L. E., Kotova, V., Zavilgelsky, G., Shakulov, R., Shatalin, K., & Nudler, E. (2017). Mechanism of H 2 S-mediated protection against oxidative stress in Escherichia coli. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1703576114
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