The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
Open accessAbstract
Significance: This paper describes the finding that mitochondria synthesize and release melatonin and have their selective G protein-coupled receptor (GPCR) in the outer membrane. We further demonstrate that mitochondrial melatonin type 1 receptors respond to melatonin by activating heterotrimeric G proteins located in the intermembrane space and inhibit stress-mediated cytochrome c release. This remarkable insight changes our classical understanding of biological GPCR function by showing that a cellular organelle both synthesizes and has a signaling receptor for a specific ligand. Implicit with our original work is the existence of an automitocrine signaling pathway by which melatonin prevents neurodegeneration associated with mitochondrial cytochrome c release and downstream caspase activation.
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Cites
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Self-citationConformational biosensors reveal GPCR signalling from endosomes
Irannejad, R., Tomshine, J. C., Tomshine, J. R., Chevalier, M., Mahoney, J. P., Steyaert, J., Rasmussen, S. G. F., Sunahara, R. K., El-Samad, H., Huang, B., et al. (2013) · Nature · doi:10.1038/nature12000 · Cited by 819
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Cited by
Melatonin Synthesis and Function: Evolutionary History in Animals and Plants
Zhao, D., Yu, Y., Shen, Y., Liu, Q., Zhao, Z., Sharma, R., & Reiter, R. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00249 · Cited by 689
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
Monzel, A. S., Enríquez, J. A., & Picard, M. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00783-1 · Cited by 606
Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., & Xu, B. (2018) · Molecules · doi:10.3390/molecules23020509 · Cited by 393
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
Galano, A., & Reiter, R. J. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12514 · Cited by 353
Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
Slominski, A. T., Hardeland, R., Zmijewski, M. A., Slominski, R. M., Reiter, R. J., & Paus, R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.10.025 · Cited by 286
Metadata
- Authors
- Suofu, Y., Li, W., Jean-Alphonse, F. G., Jia, J., Khattar, N. K., Li, J., Baranov, S. V., Leronni, D., Mihalik, A. C., He, Y., Cecon, E., Wehbi, V. L., Kim, J., Heath, B. E., Baranova, O. V., Wang, X., Gable, M. J., Kretz, E. S., Di Benedetto, G., Lezon, T. R., Ferrando, L. M., Larkin, T. M., Sullivan, M., Yablonska, S., Wang, J., Minnigh, M. B., Guillaumet, G., Suzenet, F., Richardson, R. M., Poloyac, S. M., Stolz, D. B., Jockers, R., Witt-Enderby, P. A., Carlisle, D. L., Vilardaga, J.-P., & Friedlander, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-09-05
- Volume
- 114
- Issue
- 38
- Pages
- E7997-E8006
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2750856430
- Cited by
- 414
- References
- 51
- FWCI
- 18.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Suofu, Y., Li, W., Jean-Alphonse, F. G., Jia, J., Khattar, N. K., Li, J., Baranov, S. V., Leronni, D., Mihalik, A. C., He, Y., Cecon, E., Wehbi, V. L., Kim, J., Heath, B. E., Baranova, O. V., Wang, X., Gable, M. J., Kretz, E. S., Di Benedetto, G., . . . Friedlander, R. M. (2017). Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1705768114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
