The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis
Open accessAbstract
Significance: Necroptosis is a programmed form of necrotic cell death which is implicated in a wide range of human pathological conditions. It is controlled by receptor-interacting protein kinase 3 (RIPK3) and its substrate mixed-lineage kinase domain-like protein (MLKL). Phosphorylated MLKL forms tetramers and translocates to membrane fractions to induce cell death. Here we report that MLKL tetramers further polymerize to form disulfide bond-dependent amyloid-like fibers, which are required for necroptosis. Furthermore, induced polymerization of the MLKL N-terminal domain is sufficient to activate necroptosis without RIPK3. This work reveals a mechanism for MLKL activation and generates exciting directions for necroptosis regulation.
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Cited by
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
Frank, D., & Vince, J. E. (2019) · Cell Death & Differentiation · doi:10.1038/s41418-018-0212-6 · Cited by 1,062
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 961
Necroptosis and tumor progression
Yan, J., Wan, P., Choksi, S., & Liu, Z.-G. (2022) · Trends in Cancer · doi:10.1016/j.trecan.2021.09.003 · Cited by 445
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.
Samson, A. L., Garnish, S. E., Hildebrand, J. M., & Murphy, J. M. (2021) · Science Signaling · doi:10.1126/scisignal.abc6178 · Cited by 82
Metadata
- Authors
- Liu, S., Liu, H., Johnston, A., Hanna-Addams, S., Reynoso, E., Xiang, Y., & Wang, Z.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-08-21
- Volume
- 114
- Issue
- 36
- Pages
- E7450-E7459
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2749909301
- Cited by
- 169
- References
- 11
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, S., Liu, H., Johnston, A., Hanna-Addams, S., Reynoso, E., Xiang, Y., & Wang, Z. (2017). MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1707531114
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