Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,773

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686

Inflammasomes: mechanism of assembly, regulation and signalling

Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,263

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., & Lieberman, J. (2016) · Nature · doi:10.1038/nature18629 · Cited by 3,202

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698

Non-canonical inflammasome activation targets caspase-11

Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530

Inflammatory caspases are innate immune receptors for intracellular LPS

Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,985

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

Wang, H., Sun, L., Su, L., Rizo, J., Liu, L., Wang, L., Wang, F., & Wang, X. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.003 · Cited by 1,601

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Rogers, C., Fernandes-Alnemri, T., Mayes, L., Alnemri, D., Cingolani, G., & Alnemri, E. S. (2017) · Nature Communications · doi:10.1038/ncomms14128 · Cited by 1,510

Pro-inflammatory programmed cell death

Cookson, B. T., & Brennan, M. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01936-3 · Cited by 1,422

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

Kaczmarek, A., Vandenabeele, P., & Krysko, D. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.003 · Cited by 1,411

Functions of S100 Proteins

Donato, R., Cannon, B. R., Sorci, G., Riuzzi, F., Hsu, K., Weber, D. J., & Geczy, C. L. (2012) · Current Molecular Medicine · doi:10.2174/156652413804486214 · Cited by 1,354

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Miao, E. A., Leaf, I. A., Treuting, P. M., Mao, D. P., Dors, M., Sarkar, A., Warren, S. E., Wewers, M. D., & Aderem, A. (2010) · Nature Immunology · doi:10.1038/ni.1960 · Cited by 1,336

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chiang, H.-C., Choksi, S., Liu, J., Ward, Y., Wu, L.-G., & Liu, Z.-G. (2014) · Nature Cell Biology · doi:10.1038/ncb2883 · Cited by 1,322

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

He, Y., Zeng, M. Y., Yang, D., Motro, B., & Núñez, G. (2016) · Nature · doi:10.1038/nature16959 · Cited by 1,295

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature · doi:10.1038/nature09852 · Cited by 1,278

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267

Shigella flexneri induces apoptosis in infected macrophages

Zychlinsky, A., Prévost, M., & Sansonetti, P. (1992) · Nature · doi:10.1038/358167a0 · Cited by 1,259

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

Doitsh, G., Galloway, N. L. K., Geng, X., Yang, Z., Monroe, K. M., Zepeda, O., Hunt, P. W., Hatano, H., Sowinski, S., Muñoz-Arias, I., et al. (2013) · Nature · doi:10.1038/nature12940 · Cited by 1,216

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Sborgi, L., Rühl, S., Mulvihill, E., Pipercevic, J., Heilig, R., Stahlberg, H., Farady, C. J., Müller, D. J., Broz, P., & Hiller, S. (2016) · The EMBO Journal · doi:10.15252/embj.201694696 · Cited by 1,152

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

Evavold, C. L., Ruan, J., Tan, Y., Xia, S., Wu, H., & Kagan, J. C. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.013 · Cited by 1,115

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S. (2011) · Nature · doi:10.1038/nature09857 · Cited by 1,057

Necroptosis in development, inflammation and disease

Weinlich, R., Oberst, A., Beere, H. M., & Green, D. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.149 · Cited by 1,016

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

White, M. J., McArthur, K., Metcalf, D., Lane, R. M., Cambier, J. C., Herold, M. J., van Delft, M. F., Bedoui, S., Lessene, G., Ritchie, M. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.036 · Cited by 983

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

Zhao, J., Jitkaew, S., Cai, Z., Choksi, S., Li, Q., Luo, J., & Liu, Z.-G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200012109 · Cited by 925

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Aglietti, R. A., Estevez, A., Gupta, A., Ramirez, M. G., Liu, P. S., Kayagaki, N., Ciferri, C., Dixit, V. M., & Dueber, E. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607769113 · Cited by 898

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine · doi:10.1038/nm1603 · Cited by 876

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.037 · Cited by 847

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

Dondelinger, Y., Declercq, W., Montessuit, S., Roelandt, R., Gonçalves, A. C., Bruggeman, I., Hulpiau, P., Weber, K., Sehon, C. A., Marquis, R. W., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.026 · Cited by 840

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

Chen, X., He, W.-T., Hu, L., Li, J., Fang, Y., Wang, X., Xu, X., Wang, Z., Huang, K., & Han, J. (2016) · Cell Research · doi:10.1038/cr.2016.100 · Cited by 831

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

Chen, X., Li, W., Ren, J., Huang, D., He, W., Song, Y., Yang, C., Li, W., Zheng, X., Chen, P., et al. (2013) · Cell Research · doi:10.1038/cr.2013.171 · Cited by 803

Human Monocytes Engage an Alternative Inflammasome Pathway

Gaidt, M. M., Ebert, T. S., Chauhan, D., Schmidt, T., Schmid-Burgk, J. L., Rapino, F. A., Robertson, A. A. B., Cooper, M. A., Graf, T., & Hornung, V. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.012 · Cited by 803

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I., Martínez, C. M., Amores-Iniesta, J., Compan, V., Barberà-Cremades, M., Yagüe, J., Ruiz-Ortiz, E., Antón, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2919 · Cited by 790

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

Segawa, K., & Nagata, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.08.003 · Cited by 778

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin, B. S., Bossaller, L., De Nardo, D., Ratter, J. M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S. R., Al-Amoudi, A., et al. (2014) · Nature Immunology · doi:10.1038/ni.2913 · Cited by 773

Characterization of tumor necrosis factor-deficient mice

Marino, M. W., Dunn, A. R., Grail, D., Inglese, M., Noguchi, Y., Richards, E. A., Jungbluth, A., Wada, H., Moore, M. A. S., Williamson, B., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8093 · Cited by 767

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

Cayrol, C., & Girard, J.-P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812690106 · Cited by 707

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

Gong, Y.-N., Guy, C., Olauson, H., Becker, J. U., Yang, M., Fitzgerald, P., Linkermann, A., & Green, D. R. (2017) · Cell · doi:10.1016/j.cell.2017.03.020 · Cited by 689

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

Newton, K., Dugger, D. L., Wickliffe, K. E., Kapoor, N., de Almagro, M. C., Vucic, D., Komuves, L., Ferrando, R. E., French, D. M., Webster, J., et al. (2014) · Science · doi:10.1126/science.1249361 · Cited by 687

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Lüthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G., Taylor, R. C., Kersse, K., Vandenabeele, P., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.007 · Cited by 677

IL-33 is a crucial amplifier of innate rather than acquired immunity

Oboki, K., Ohno, T., Kajiwara, N., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T., Kiyonari, H., Matsumoto, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003059107 · Cited by 670

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Lawlor, K. E., Khan, N. R., Mildenhall, A., Gerlic, M., Croker, B. A., D’Cruz, A. A., Hall, C. M., Spall, S. K., Anderton, H., Masters, S. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7282 · Cited by 660

RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells

Yatim, N., Jusforgues-Saklani, H., Orozco, S. L., Schulz, O., da Silva, R. B., Sousa, C. R. E., Green, D. R., Oberst, A., & Albert, M. L. (2015) · Science · doi:10.1126/science.aad0395 · Cited by 643

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Berghe, T. V., Vanlangenakker, N., Parthoens, E., Deckers, W., Devos, M., Festjens, N., Guerin, C. J., Brunk, U. T., Declercq, W., & Vandenabeele, P. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.184 · Cited by 639

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

Duprez, L., Takahashi, N., Hauwermeiren, F. V., Vandendriessche, B., Goossens, V., Berghe, T. V., Declercq, W., Libert, C., Cauwels, A., & Vandenabeele, P. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.020 · Cited by 607

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408987111 · Cited by 598

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

Rickard, J. A., O’Donnell, J. A., Evans, J. M., Lalaoui, N., Poh, A. R., Rogers, T., Vince, J. E., Lawlor, K. E., Ninnis, R. L., Anderton, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.019 · Cited by 597

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Boucher, D., Monteleone, M. M., Coll, R. C., Chen, K. W., Ross, C. M., Teo, J. L., Gomez, G. A., Holley, C. L., Bierschenk, D., Stacey, K. J., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172222 · Cited by 578

Interleukin 1α and the inflammatory process

Di Paolo, N. C., & Shayakhmetov, D. M. (2016) · Nature Immunology · doi:10.1038/ni.3503 · Cited by 568

Initiation and execution mechanisms of necroptosis: an overview

Grootjans, S., Vanden Berghe, T., & Vandenabeele, P. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.65 · Cited by 566

Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K + efflux

Rühl, S., & Brož, P. (2015) · European Journal of Immunology · doi:10.1002/eji.201545772 · Cited by 546

Caspase-11 Protects Against Bacteria That Escape the Vacuole

Aachoui, Y., Leaf, I. A., Hagar, J. A., Fontana, M. F., Campos, C. G., Zak, D. E., Tan, M. H., Cotter, P. A., Vance, R. E., Aderem, A. A., et al. (2013) · Science · doi:10.1126/science.1230751 · Cited by 544

The diverse role of RIP kinases in necroptosis and inflammation

Silke, J., Rickard, J. A., & Gerlic, M. (2015) · Nature Immunology · doi:10.1038/ni.3206 · Cited by 530

Programmed cell death—I. Cytology of degeneration in the intersegmental muscles of the Pernyi silkmoth

Lockshin, R. A., & Williams, C. M. (1965) · Journal of Insect Physiology · doi:10.1016/0022-1910(65)90099-5 · Cited by 492

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

Vince, J. E., Wong, W. W.-L., Gentle, I., Lawlor, K. E., Allam, R., O'Reilly, L., Mason, K., Gross, O., Ma, S., Guarda, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.012 · Cited by 491

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Conos, S. A., Chen, K. W., De Nardo, D., Hara, H., Whitehead, L., Núñez, G., Masters, S. L., Murphy, J. M., Schroder, K., Vaux, D. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613305114 · Cited by 485

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

Lamkanfi, M., Sarkar, A., Walle, L. V., Vitari, A. C., Amer, A. O., Wewers, M. D., Tracey, K. J., Kanneganti, T., & Dixit, V. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000803 · Cited by 482

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

Groß, O., Yazdi, A. S., Thomas, C. J., Masin, M., Heinz, L. X., Guarda, G., Quadroni, M., Drexler, S. K., & Tschopp, J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.018 · Cited by 479

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

Linkermann, A., Bräsen, J. H., Himmerkus, N., Liu, S., Huber, T. B., Kunzendorf, U., & Krautwald, S. (2012) · Kidney International · doi:10.1038/ki.2011.450 · Cited by 462

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

Wu, J., Huang, Z., Ren, J., Zhang, Z., He, P., Li, Y., Ma, J., Chen, W., Zhang, Y., Zhou, X., et al. (2013) · Cell Research · doi:10.1038/cr.2013.91 · Cited by 462

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way

Piccini, A., Carta, S., Tassi, S., Lasigliè, D., Fossati, G., & Rubartelli, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709684105 · Cited by 460

Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

Yu, J.-J., Nagasu, H., Murakami, T., Hoang, H., Broderick, L., Hoffman, H., & Horng, T. (2014) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1414859111 · Cited by 449

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

Newton, K., Dugger, D. L., Maltzman, A., Greve, J. M., Hedehus, M., Martin-McNulty, B., Carano, R. A. D., Cao, T. C., van Bruggen, N., Bernstein, L., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.46 · Cited by 447

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

Mayor, A., Martinon, F., Smedt, T. D., Pétrilli, V., & Tschopp, J. (2007) · Nature Immunology · doi:10.1038/ni1459 · Cited by 438

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Kambara, H., Liu, F., Zhang, X., Liu, P., Bajrami, B., Teng, Y., Zhao, L., Zhou, S., Yu, H., Zhou, W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.067 · Cited by 424

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

Lin, J., Kumari, S., Kim, C., Van, T.-M., Wachsmuth, L., Polykratis, A., & Pasparakis, M. (2016) · Nature · doi:10.1038/nature20558 · Cited by 421

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

Kang, T.-B., Yang, S.-H., Toth, B., Kovalenko, A., & Wallach, D. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.015 · Cited by 419

Cryo-EM structure of the gasdermin A3 membrane pore

Ruan, J., Xia, S., Liu, X., Lieberman, J., & Wu, H. (2018) · Nature · doi:10.1038/s41586-018-0058-6 · Cited by 414

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

Jorgensen, I., Zhang, Y., Krantz, B. A., & Miao, E. A. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151613 · Cited by 403

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

Chen, K. W., Groß, C. J., Sotomayor, F. V., Stacey, K. J., Tschopp, J., Sweet, M. J., & Schroder, K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.028 · Cited by 400

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

Menu, P., & Vince, J. E. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04440.x · Cited by 397

The Gasdermin‐D pore acts as a conduit for IL‐1β secretion in mice

Heilig, R., Dick, M. S., Sborgi, L., Meunier, É., Hiller, S., & Brož, P. (2017) · European Journal of Immunology · doi:10.1002/eji.201747404 · Cited by 397

RIPK1 inhibits ZBP1-driven necroptosis during development

Newton, K., Wickliffe, K. E., Maltzman, A., Dugger, D. L., Strasser, A., Pham, V. C., Lill, J. R., Roose-Girma, M., Warming, S., Solon, M., et al. (2016) · Nature · doi:10.1038/nature20559 · Cited by 390

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

de Vasconcelos, N. M., Opdenbosch, N. V., Gorp, H. V., Parthoens, E., & Lamkanfi, M. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0106-7 · Cited by 380

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5

Baker, P. J., Boucher, D., Bierschenk, D., Tebartz, C., Whitney, P. G., D’Silva, D. B., Tanzer, M. C., Monteleone, M. M., Robertson, A. A. B., Cooper, M. A., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545655 · Cited by 370

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

Yoon, S., Kovalenko, A., Bogdanov, K., & Wallach, D. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.001 · Cited by 368

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

Wu, H., Ma, J., Wang, P., Corpuz, T. M., Panchapakesan, U., Wyburn, K., & Chadban, S. J. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009101048 · Cited by 359

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76887 · Cited by 355

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Dang, E. V., McDonald, J. G., Russell, D. W., & Cyster, J. G. (2017) · Cell · doi:10.1016/j.cell.2017.09.029 · Cited by 348

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

Mompeán, M., Li, W., Li, J., Laage, S., Siemer, A. B., Bozkurt, G., Wu, H., & McDermott, A. E. (2018) · Cell · doi:10.1016/j.cell.2018.03.032 · Cited by 342

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

Maelfait, J., Vercammen, E., Janssens, S., Schotte, P., Haegman, M., Magez, S., & Beyaert, R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071632 · Cited by 335

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

Masters, S. L., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O’Donnell, J. A., McArthur, K., Baldwin, T. M., Chevrier, S., Nowell, C. J., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.027 · Cited by 313

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Monteleone, M. M., Stanley, A. C., Chen, K. W., Brown, D. L., Bezbradica, J. S., von Pein, J. B., Holley, C. L., Boucher, D., Shakespear, M. R., Kapétanovic, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.027 · Cited by 309

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126975 · Cited by 301

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Schneider, K. S., Groß, C. J., Dreier, R. F., Saller, B. S., Mishra, R., Gorka, O., Heilig, R., Meunier, É., Dick, M. S., Ćiković, T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.12.018 · Cited by 295

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Yang, Z., Wang, Y., Zhang, Y., He, X., Zhong, C., Ni, H., Chen, X., Liang, Y., Wu, J., Zhao, S., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0022-y · Cited by 292

Role of NLRP3 Inflammasomes in Atherosclerosis

Karasawa, T., & Takahashi, M. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17001 · Cited by 283

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

Duong, B. H., Onizawa, M., Osés-Prieto, J. A., Advincula, R., Burlingame, A. L., Malynn, B. A., & Ma, A. I. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.031 · Cited by 275

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

Kitur, K., Parker, D., Nieto, P. A., Ahn, D. S., Cohen, T. S., Chung, S., Wachtel, S., Bueno, S. M., & Prince, A. S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004820 · Cited by 272

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

Lin, J., Li, H., Yang, M. H., Ren, J., Huang, Z., Han, F., Huang, J., Ma, J., Zhang, D., Zhang, Z., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.12.012 · Cited by 266

Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage

Talabot‐Ayer, D., Lamacchia, C., Gabay, C., & Palmer, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901744200 · Cited by 258

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.008 · Cited by 255

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

Quarato, G., Guy, C. S., Grace, C. R., Llambi, F., Nourse, A., Rodríguez, D. A., Wakefield, R., Frase, S., Moldoveanu, T., & Green, D. R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.011 · Cited by 244

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Alvarez-Diaz, S., Dillon, C. P., Lalaoui, N., Tanzer, M. C., Rodriguez, D. A., Lin, A., Lebois, M., Hakem, R., Josefsson, E. C., O’Reilly, L. A., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.016 · Cited by 242

Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection

Orzalli, M. H., & Kagan, J. C. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.05.007 · Cited by 241

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α

Berda‐Haddad, Y., Robert, S., Salers, P., Zekraoui, L., Farnarier, C., Dinarello, C. A., Dignat‐George, F., & Kaplanski, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116848108 · Cited by 240

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

Xu, J., Jiang, Y., Wang, J., Shi, X., Liu, Q., Liu, Z., Li, Y., Scott, M. J., Xiao, G., Li, S., et al. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2014.40 · Cited by 239

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming

Allam, R., Lawlor, K. E., Yu, E. C.-W., Mildenhall, A., Moujalled, D. M., Lewis, R. S., Ke, F., Mason, K. D., White, M. J., Stacey, K. J., et al. (2014) · EMBO Reports · doi:10.15252/embr.201438463 · Cited by 238

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

Gutierrez, K. D., Davis, M. A., Daniels, B. P., Olsen, T. M., Ralli-Jain, P., Tait, S. W. G., Gale, M., & Oberst, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601757 · Cited by 237

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

Cullen, S. P., Kearney, C. J., Clancy, D. M., & Martin, S. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.003 · Cited by 234

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

Brydges, S. D., Broderick, L., McGeough, M. D., Peña, C. A., Mueller, J. L., & Hoffman, H. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71543 · Cited by 234

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

Shigeoka, A. A., Mueller, J. L., Kambo, A., Mathison, J. C., King, A. J., Hall, W. F., Correia, J. D. S., Ulevitch, R. J., Hoffman, H. M., & McKay, D. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002330 · Cited by 229

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

Kovalenko, A., Kim, J., Kang, T., Rajput, A., Bogdanov, K., Dittrich‐Breiholz, O., Kracht, M., Brenner, O. J., & Wallach, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090616 · Cited by 214

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

Zheng, Y., Humphry, M., Maguire, J. J., Bennett, M. R., & Clarke, M. C. H. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.008 · Cited by 205

RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival

Lau, A. N., Wang, S., Jiang, J., Haig, A. R., Pavlosky, A., Linkermann, A., Zhang, Z.-X., & Jevnikar, A. M. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12447 · Cited by 204

MLKL forms cation channels

Xia, B., Fang, S., Chen, X., Hu, H., Chen, P., Wang, H., & Gao, Z. (2016) · Cell Research · doi:10.1038/cr.2016.26 · Cited by 202

Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals

Maeda, A., & Fadeel, B. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.277 · Cited by 201

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

Russo, H. M., Rathkey, J. K., Tressler, A. B., Katsnelson, M. A., Abbott, D. W., & Dubyak, G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600699 · Cited by 194

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

Zargarian, S., Shlomovitz, I., Erlich, Z., Hourizadeh, A., Ofir‐Birin, Y., Croker, B. A., Regev‐Rudzki, N., Edry‐Botzer, L., & Gerlic, M. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002711 · Cited by 194

HSP70 Protects against TNF-Induced Lethal Inflammatory Shock

Molle, W. V., Wielockx, B., Mahieu, T., Takada, M., Taniguchi, T., Sekikawa, K., & Libert, C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00310-2 · Cited by 191

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

Yang, H., Ma, Y., Chen, G., Zhou, H., Yamazaki, T., Klein, C., Pietrocola, F., Vacchelli, E., Souquère, S., Sauvat, A., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1149673 · Cited by 188

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Kanneganti, A., Malireddi, R. K. S., Saavedra, P. H. V., Walle, L. V., Gorp, H. V., Kambara, H., Sheppard, H., Vogel, P., Luo, H. R., Xavier, R. J., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172060 · Cited by 182

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling

Kitur, K., Wachtel, S., Brown, A. O., Wickersham, M., Paulino, F. E., Peñaloza, H. F., Soong, G., Bueno, S. M., Parker, D., & Prince, A. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.039 · Cited by 181

Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin

Elmezayen, R., Gazzar, M. E., Seeds, M. C., McCall, C. E., Dreskin, S. C., & Nicolls, M. R. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.04.011 · Cited by 178

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti, G., Ma, C.-Y., Lalaoui, N., Nguyen, N.-Y. N., Navarro, M., Tanzer, M., Richmond, J., Ghisi, M., Salmon, J., Silke, N., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3099 · Cited by 176

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

Liu, S., Liu, H., Johnston, A. N., Hanna-Addams, S., Reynoso, E., Xiang, Y., & Wang, Z. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707531114 · Cited by 175

Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock

Berghe, T. V., Demon, D., Bogaert, P., Vandendriessche, B., Goethals, A., Depuydt, B., Vuylsteke, M., Roelandt, R., Van Wonterghem, E., Vandenbroecke, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201308-1535oc · Cited by 173

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

Weber, K., Roelandt, R., Bruggeman, I., Estornes, Y., & Vandenabeele, P. (2018) · Communications Biology · doi:10.1038/s42003-017-0007-1 · Cited by 170

A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection

Liu, X., & Lieberman, J. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.02.002 · Cited by 167

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

Maltez, V. I., Tubbs, A. L., Cook, K. D., Aachoui, Y., Falcone, E. L., Holland, S. M., Whitmire, J. K., & Miao, E. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.010 · Cited by 165

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

Jacobsen, A. V., Lowes, K. N., Tanzer, M. C., Lucet, I. S., Hildebrand, J. M., Petrie, E. J., van Delft, M. F., Liu, Z., Conos, S. A., Zhang, J.-G., et al. (2016) · Cell Death & Disease · doi:10.1038/cddis.2015.386 · Cited by 160

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it

Yoon, S., Bogdanov, K., Kovalenko, A., & Wallach, D. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.92 · Cited by 151

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

Ros, U., Peña‐Blanco, A., Hänggi, K., Kunzendorf, U., Krautwald, S., Wong, W. W.-L., & García‐Sáez, A. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.024 · Cited by 141

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation

Lawlor, K. E., Feltham, R., Yabal, M., Conos, S. A., Chen, K. W., Ziehe, S., Graß, C., Zhan, Y., Nguyen, T. A., Hall, C. M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.073 · Cited by 139

TLR activation regulates damage‐associated molecular pattern isoforms released during pyroptosis

Nyström, S., Antoine, D. J., Lundbäck, P., Lock, J. G., Niță, A. F., Högstrand, K., Grandien, A., Erlandsson-Harris, H., Andersson, U., & Applequist, S. E. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.328 · Cited by 138

Dichotomy between RIP1- and RIP3-Mediated Necroptosis in Tumor Necrosis Factor-α-Induced Shock

Linkermann, A., Bräsen, J. H., Zen, F. D., Weinlich, R., Schwendener, R. A., Green, D. R., Kunzendorf, U., & Krautwald, S. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00423 · Cited by 137

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

Kearney, C. J., Cullen, S. P., Tynan, G. A., Henry, C. M., Clancy, D. M., Lavelle, E. C., & Martin, S. J. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.222 · Cited by 135

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

Aachoui, Y., Kajiwara, Y., Leaf, I. A., Mao, D., Ting, J. P.-Y., Coers, J., Aderem, A., Buxbaum, J. D., & Miao, E. A. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.016 · Cited by 125

Alternative inflammasome activation enables IL-1β release from living cells

Gaidt, M. M., & Hornung, V. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.10.007 · Cited by 124

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL

McComb, S., Aguadé-Gorgorió, J., Behrmann, L., Marovca, B., Cario, G., Eckert, C., Schrappe, M., Stanulla, M., von Stackelberg, A., Bourquin, J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad2986 · Cited by 117

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages

Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S., & Suda, T. (2013) · International Immunology · doi:10.1093/intimm/dxs161 · Cited by 108

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

Madouri, F., Guillou, N., Fauconnier, L., Marchiol, T., Rouxel, N., Chenuet, P., Ledru, A., Apétoh, L., Ghiringhelli, F., Chamaillard, M., et al. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv012 · Cited by 106

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes

Stevens, N. E., Chapman, M. J., Fraser, C. K., Kuchel, T. R., Hayball, J. D., & Diener, K. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-06205-z · Cited by 105

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion

Conos, S. A., Lawlor, K. E., Vaux, D. L., Vince, J. E., & Lindqvist, L. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.69 · Cited by 102

Tissue damage negatively regulates LPS-induced macrophage necroptosis

Li, Z. A., Scott, M. J., Fan, E., Li, Y., Liu, J., Xiao, G., Li, S., Billiar, T. R., Wilson, M. A., Jiang, Y., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.21 · Cited by 98

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

Ramirez, M. L. G., Poręba, M., Snipas, S. J., Groborz, K. M., Drąg, M., & Salvesen, G. S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001329 · Cited by 97

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

Khan, N. R., Lawlor, K. E., Murphy, J. M., & Vince, J. E. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.10.017 · Cited by 93

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion

Lindqvist, L., Frank, D. O., McArthur, K., Dite, T. A., Lazarou, M., Oakhill, J. S., Kile, B. T., & Vaux, D. L. (2017) · Cell Death and Differentiation · doi:10.1038/s41418-017-0017-z · Cited by 82

A Tissue-Specific Role for Nlrp3 in Tubular Epithelial Repair after Renal Ischemia/Reperfusion

Bakker, P. J., Butter, L. M., Claessen, N., Teske, G. J. D., Sutterwala, F. S., Florquin, S., & Leemans, J. C. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.04.005 · Cited by 76

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Speir, M., Lawlor, K. E., Glaser, S. P., Abraham, G., Chow, S. H., Vogrin, A. J., Schulze, K. E., Schuelein, R., O’Reilly, L. A., Mason, K. D., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2015.34 · Cited by 75

Targeting apoptosis pathways in infections

Naderer, T., & Fulcher, M. C. (2018) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0717-286r · Cited by 62

Controlled detonation: evolution of necroptosis in pathogen defense

Brault, M., & Oberst, A. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.117 · Cited by 57

Heat shock proteins and high mobility group box 1 protein lack cytokine function

Tsan, M. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810471 · Cited by 55

Post-translational control of RIPK3 and MLKL mediated necroptotic cell death

Murphy, J. M., & Vince, J. E. (2015) · F1000Research · doi:10.12688/f1000research.7046.1 · Cited by 55

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3

Kang, T., Jeong, J.-S., Yang, S., Kovalenko, A., & Wallach, D. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0104-9 · Cited by 39

Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

Yu, S.-X., Chen, W., Liu, Z., Zhou, F., Yan, S.-Q., Hu, G., Qin, X., Zhang, J., Ma, K., Du, C., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00119 · Cited by 31

Masters, marionettes and modulators: intersection of pathogen virulence factors and mammalian death receptor signaling

Silke, J., & Hartland, E. L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.011 · Cited by 28

Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model

Menzel, M., Akbarshahi, H., Persson, I. M., Puthia, M., Bjermer, L. H., & Uller, L. (2017) · ERJ Open Research · doi:10.1183/23120541.00047-2017 · Cited by 20

Intracellular il-1 receptor 2 binding prevents cleavage and activity of IL-1ALPHA, controlling necrosis-induced sterile inflammation

Zheng, Y., Humphry, M., Maguire, J. J., Bennett, M. R., & Clarke, M. C. H. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.10.023 · Cited by 18

Outcome Measures for Gout Clinical Trials: a Summary of Progress

de Lautour, H., Dalbeth, N., & Taylor, W. J. (2015) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-015-0014-7 · Cited by 9

Chronic inflammation in the etiology of disease across the life span

Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915

Cytokine storm

Fajgenbaum, D. C., & June, C. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2026131 · Cited by 3,196

Pyroptosis: Mechanisms and Diseases

Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00507-5 · Cited by 2,353

NLRP3 inflammasome activation and cell death

Huang, Y., Xu, W., & Zhou, R. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00740-6 · Cited by 1,527

Reactive Oxygen Species: Drivers of Physiological and Pathological Processes

Checa, J., & Aran, J. M. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s275595 · Cited by 1,060

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 1,000

Role of pyroptosis in inflammation and cancer

Xiang, W. D., Xie, F., Zhou, X., Wu, Y., Yan, H., Liu, T., Huang, J. S., Wang, F., Zhou, F., & Zhang, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00905-x · Cited by 728

Cell death due to electroporation – A review

Napotnik, T. B., Polajžer, T., & Miklavčič, D. (2021) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2021.107871 · Cited by 585

Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

Hsu, S., Li, C., Lin, I., Syue, W.-J., Chen, Y., Cheng, K., Teng, Y., Lin, Y., Yen, C., & Chiu, C. (2021) · Theranostics · doi:10.7150/thno.62521 · Cited by 502

A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Ye, Y., Dai, Q., & Qi, H. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00451-x · Cited by 454

Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases

Wicherska‐Pawłowska, K., Wróbel, T., & Rybka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413397 · Cited by 451

Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

Meier, P., Legrand, A. J., Adam, D., & Silke, J. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00674-x · Cited by 435

Necroptosis: a crucial pathogenic mediator of human disease

Choi, M. E., Price, D. R., Ryter, S. W., & Choi, A. M. K. (2019) · JCI Insight · doi:10.1172/jci.insight.128834 · Cited by 425

Targeting RIPK1 for the treatment of human diseases

Degterev, A., Ofengeim, D., & Yuan, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901179116 · Cited by 415

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

Wajant, H., & Siegmund, D. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00091 · Cited by 415

Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

Flerlage, T., Boyd, D. F., Meliopoulos, V., Thomas, P. G., & Schultz‐Cherry, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00542-7 · Cited by 415

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective

Liu, Y., Pan, R., Ouyang, Y., Gu, W., Xiao, T., Yang, H., Tang, L. Y., Wang, H., Xiang, B., & Chen, P. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01958-2 · Cited by 391

Signaling pathways and intervention therapies in sepsis

Zhang, Y., & Ning, B. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00816-9 · Cited by 369

Nanoparticle Toxicology

Yang, W., Wang, L., Mettenbrink, E. M., DeAngelis, P. L., & Wilhelm, S. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-032320-110338 · Cited by 366

The therapeutic potential of targeting regulated non-apoptotic cell death

Hadian, K., & Stockwell, B. R. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00749-8 · Cited by 349

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

Pedrera, L., Espiritu, R. A., Ros, U., Weber, J., Schmitt, A. M., Stroh, J., Hailfinger, S., von Karstedt, S., & García‐Sáez, A. J. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00691-x · Cited by 322

Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke

Mao, R., Zong, N., Hu, Y., Chen, Y., & Xu, Y. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00859-0 · Cited by 296

Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management (Review)

He, J., Liu, D., Zhao, L., Zhou, D., Rong, J., Zhang, L., & Xia, Z. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11357 · Cited by 287

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

Ferreira, A. C., Soares, V. C., de Azevedo-Quintanilha, I. G., Dias, S. D. S. G., Rodrigues, N. F., Sacramento, C. Q., Mattos, M., de Freitas, C. S., Temerozo, J. R., Teixeira, L., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00428-w · Cited by 283

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Beckwith, K. S., Beckwith, M. S., Ullmann, S., Sætra, R. S., Kim, H., Marstad, A., Åsberg, S. E., Strand, T. A., Haug, M., Niederweis, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16143-6 · Cited by 282

Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway

Zhang, J., Huang, L., Shi, X., Yang, L., Hua, F., Ma, J., Zhu, W., Liu, X., Xuan, R., Shen, Y., et al. (2020) · Aging · doi:10.18632/aging.202143 · Cited by 272

Caspase-8: The double-edged sword

Mandal, R., Compte, J., Kostova, I., Becker, S., & Strebhardt, K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188357 · Cited by 261

Guidelines for evaluating myocardial cell death

Mishra, P. K., Adameová, A., Hill, J. A., Baines, C. P., Kang, P. M., Downey, J. M., Narula, J., Takahashi, M., Abbate, A., Piristine, H. C., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00259.2019 · Cited by 245

Programmed cell death in atherosclerosis and vascular calcification

Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 243

Insights into N6-methyladenosine and programmed cell death in cancer

Liu, L., Li, H., Hu, D., Wang, Y., Shao, W., Zhong, J., Yang, S., Liu, J., & Zhang, J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01508-w · Cited by 241

Immunological mechanisms and therapeutic targets of fatty liver diseases

Wang, H., Mehal, W. Z., Nagy, L. E., & Rotman, Y. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00579-3 · Cited by 234

Lytic cell death in metabolic liver disease

Gautheron, J., Gores, G. J., & Rodrigues, C. M. P. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.001 · Cited by 225

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

Wang, J., Zhu, P., Li, R., Ren, J. T., & Zhou, H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101415 · Cited by 223

Ferroptosis as a potential target for cancer therapy

Chen, Z., Wang, W., Razak, S. R. A., Han, T., Ahmad, N. H., & Li, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05930-w · Cited by 223

Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway

Shen, S., He, F., Cheng, C., Xu, B., & Sheng, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110990 · Cited by 221

PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

Shi, C., Cao, P., Wang, Y., Zhang, Q., Zhang, D., Wang, Y., Wang, L., & Gong, Z. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s403819 · Cited by 217

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy

Li, Y., Yuan, Y., Huang, Z., Chen, H., Lan, R., Wang, Z., Lai, K., Chen, H., Chen, Z., Zou, Z., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00755-6 · Cited by 212

Fighting age-related orthopedic diseases: focusing on ferroptosis

Ru, Q., Li, Y., Xie, W., Ding, Y., Chen, L., Xu, G., Wu, Y., & Wang, F. (2023) · Bone Research · doi:10.1038/s41413-023-00247-y · Cited by 211

Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control

Zhu, H., Tan, Y., Du, W., Li, Y., Toan, S., Mui, D., Tian, F., & Zhou, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101777 · Cited by 188

PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment

Gao, J., Xiong, A., Liu, J., Li, X., Wang, J., Zhang, L., Liu, Y., Xiong, Y., Li, G., & He, X. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00765-9 · Cited by 188

Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials

Wang, J., Toan, S., & Zhou, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104771 · Cited by 187

Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond

Dho, S. H., Cho, M., Woo, W., Jeong, S., & Kim, L. K. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01470-9 · Cited by 175

Pyroptosis in inflammation-related respiratory disease

Feng, Y., Li, M., Yangzhong, X., Zhang, X., Zu, A., Hou, Y., Li, L., & Sun, S. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00909-1 · Cited by 171

TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses

Rienzo, M. D., Romagnoli, A., Antonioli, M., Piacentini, M., & Fimia, G. M. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0495-2 · Cited by 169

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

Kalinski, A. L., Yoon, C., Huffman, L. D., Duncker, P. C., Kohen, R., Passino, R., Hafner, H., Johnson, C. N., Kawaguchi, R., Carbajal, K. S., et al. (2020) · eLife · doi:10.7554/elife.60223 · Cited by 168

The hidden power of secondary metabolites in plant-fungi interactions and sustainable phytoremediation

Elhamouly, N. A., Hewedy, O. A., Zaitoon, A., Miraples, A., Elshorbagy, O. T., Hussien, S. M., El-Tahan, A. M., & Peng, D. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1044896 · Cited by 164

Roles of NLRP3 inflammasome in intervertebral disc degeneration

Chao-yang, G., Peng, C., & Hai-hong, Z. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.02.204 · Cited by 162

Targeting pyroptosis as a preventive and therapeutic approach for stroke

Long, J., Sun, Y., Liu, S., Yang, S., Chen, C., Zhang, Z., Chu, S., Yang, Y., Pei, G., Lin, M., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01440-y · Cited by 158

Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life

Stringer, J. M., Alesi, L. R., Winship, A., & Hutt, K. J. (2023) · Human Reproduction Update · doi:10.1093/humupd/dmad005 · Cited by 157

Human and environmental safety of carbon nanotubes across their life cycle

Kim, M., Goerzen, D., Jena, P. V., Zeng, E., Pasquali, M., Meidl, R. A., & Heller, D. A. (2023) · Nature Reviews Materials · doi:10.1038/s41578-023-00611-8 · Cited by 154

Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

Zhou, Y., Liao, J., Mei, Z., Liu, X., & Ge, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9991001 · Cited by 151

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

Anderton, H., Wicks, I. P., & Silke, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0455-8 · Cited by 150

Innate Immune Responses to Acute Viral Infection During Pregnancy

Cornish, E. F., Filipovic, I., Åsenius, F., Williams, D. J., & McDonnell, T. C. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572567 · Cited by 149

GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma

Liu, M., Li, H., Yang, R., Ji, D., & Xia, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02626-4 · Cited by 147

The gasdermin family: emerging therapeutic targets in diseases

Zhu, C., Xu, S., Jiang, R., Yu, Y., Bian, J., & Zou, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01801-8 · Cited by 149

Mitochondrial quality surveillance as a therapeutic target in myocardial infarction

Zhu, H., Toan, S., Mui, D., & Zhou, H. (2020) · Acta Physiologica · doi:10.1111/apha.13590 · Cited by 142

Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

Guo, Z., Zhang, Z., Prajapati, M., & Li, Y. (2021) · Viruses · doi:10.3390/v13091876 · Cited by 142

Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy

Luo, T., Jia, X., Feng, W.-D., Wang, J., Xie, F., Kong, L., Wang, X., Lian, R., Liu, X., Chu, Y.-J., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01094-7 · Cited by 140

The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles

Hu, Y., Liu, Y., Zong, L., Zhang, W., Liu, R., Xing, Q., Liu, Z., Yan, Q., Li, W., Lei, H., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06382-y · Cited by 140

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

Fan, R., Sui, J., Dong, X., Jing, B., & Gao, Z. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.009 · Cited by 139

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis

Chen, H., Li, Y., Wu, J., Li, G., Tao, X., Lai, K., Yuan, Y., Zhang, X., Zou, Z., & Xu, Y. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0524-1 · Cited by 138

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy

Lin, H., Xiong, W. G., Fu, L., Yi, J., & Yang, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00305-3 · Cited by 137

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

Russo, A. J., Vasudevan, S. O., Méndez‐Huergo, S. P., Kumari, P. H., Ménoret, A., Duduskar, S. N., Wang, C., Sáez, J. M. P., Fettis, M. M., Li, C., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00844-7 · Cited by 132

Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?

Sena-dos-Santos, C., Braga-da-Silva, C., Marques, D., Pinheiro, J. A. D. S., Ribeiro‐dos‐Santos, Â., & Cavalcante, G. C. (2021) · Cells · doi:10.3390/cells10020479 · Cited by 132

Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion

Chen, W., Chen, S., Yan, C., Zhang, Y., Zhang, R., Chen, M., Zhong, S., Fan, W., Zhu, S., Zhang, D., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01255-6 · Cited by 132

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review

Ohnishi, T., Iwasaki, N., & Sudo, H. (2022) · Cells · doi:10.3390/cells11030394 · Cited by 130

Uptake and toxicity of polystyrene micro/nanoplastics in gastric cells: Effects of particle size and surface functionalization

Banerjee, A., Billey, L. O., & Shelver, W. L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260803 · Cited by 128

Significance of the cGAS-STING Pathway in Health and Disease

Zhou, J., Zhuang, Z., Li, J., & Feng, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713316 · Cited by 126

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis

Wu, J., Lin, S., Chen, W., Lian, G., Wu, W., Chen, A., Sagor, M. I. H., Luo, L., Wang, H., & Xie, L. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01365-6 · Cited by 122

Oxidants, Antioxidants and Thiol Redox Switches in the Control of Regulated Cell Death Pathways

Benhar, M. (2020) · Antioxidants · doi:10.3390/antiox9040309 · Cited by 121

DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis

Le, X., Mu, J., Peng, W., Tang, J., Xiang, Q., Tian, S., Feng, Y., He, S., Qiu, Z., Ren, G., et al. (2020) · Theranostics · doi:10.7150/thno.45631 · Cited by 121

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release

Rashidi, M., Simpson, D. S., Hempel, A., Frank, D. O., Petrie, E. J., Vince, A. J., Feltham, R., Murphy, J., Chatfield, S. M., Salvesen, G. S., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900228 · Cited by 120

Targeting regulated cell death in tumor nanomedicines

Zeng, Q., Ma, X., Song, Y., Chen, Q., Jiao, Q., & Zhou, L. (2021) · Theranostics · doi:10.7150/thno.67932 · Cited by 120

Protective Effects of Remimazolam on Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting of NLRP3 Inflammasome-Dependent Pyroptosis

Shi, M., Chen, J., Liu, T., Dai, W., Zhou, Z., Chen, L., & Xie, Y. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s344240 · Cited by 124

Roles of Macrophages in Atherogenesis

Farahi, L., Sinha, S. K., & Lusis, A. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.785220 · Cited by 117

Different types of cell death in diabetic endothelial dysfunction

Shen, J., San, W., Zheng, Y., Zhang, S., Cao, D., Chen, Y., & Meng, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115802 · Cited by 117

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Mata, R., Yao, Y., Cao, W., Ding, J., Zhou, T., Zhai, Z., & Gao, C. (2021) · Research · doi:10.34133/2021/4189516 · Cited by 116

Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling

Chai, S., Yang, Y., Wei, L., Cao, Y., Ma, J., Zheng, X., Teng, J., & Qin, N. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155516 · Cited by 116

Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication

Wang, H., Wang, T., Yan, S., Tang, J., Zhang, Y., Wang, L., Xu, H., & Tu, C. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02183-9 · Cited by 122

Current evidence and therapeutic implication of PANoptosis in cancer

Ocansey, D. K. W., Qian, F., Cai, P., Ocansey, S., Amoah, S., Qian, Y.-C., & Mao, F. (2023) · Theranostics · doi:10.7150/thno.91814 · Cited by 114

Pathobiology of Myocardial Ischemia and Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, and Clinical Applications

Buja, L. M. (2022) · Cardiology in Review · doi:10.1097/crd.0000000000000440 · Cited by 108

Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases

Lawlor, K. E., Murphy, J. M., & Vince, J. E. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.011 · Cited by 108

Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity

Guo, Z., Liu, Y., Chen, D., Sun, Y., Li, D., Meng, Y., Zhou, Q., Zeng, F., Deng, G., & Chen, X. (2025) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2025-0004 · Cited by 111

Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy

Wei, J., Zhao, Y., Liang, H., Du, W., & Wang, L. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.026 · Cited by 106

ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host Immunity

Yu, H., Yang, B., Yang, J., Shi, X., Yang, X., Zhang, D., Zhao, D., Yan, W., Chen, L., Zheng, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810224 · Cited by 106

Sirt3 modulate renal ischemia‐reperfusion injury through enhancing mitochondrial fusion and activating the ERK‐OPA1 signaling pathway

Wang, Q., Xu, J., Li, X., Liu, Z., Han, Y., Xu, X., Li, X., Tang, Y., Liu, Y., Tao, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28918 · Cited by 105

Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus

Yang, F., He, Y., Zhai, Z., & Sun, E. (2019) · Journal of Immunology Research · doi:10.1155/2019/3638562 · Cited by 105

Induction of Pyroptosis: A Promising Strategy for Cancer Treatment

Wang, L., Qin, X., Liang, J., & Ge, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.635774 · Cited by 105

Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases

Okude, H., Ori, D., & Kawai, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.625833 · Cited by 104

Research progress on gut health of farmers teleost fish: a viewpoint concerning the intestinal mucosal barrier and the impact of its damage

Zhang, H., Ran, C., Teame, T., Ding, Q., Hoseinifar, S. H., Xie, M., Zhang, Z., Yang, Y., Olsen, R. E., Gatlin, D. M., et al. (2020) · Reviews in Fish Biology and Fisheries · doi:10.1007/s11160-020-09614-y · Cited by 102

Different types of cell death and their interactions in myocardial ischemia–reperfusion injury

Du, B., Fu, Q., Yang, Q., Yang, Y., Li, R. Q., Yang, X., Yang, Q., Li, S., Tian, J., & Liu, H. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02372-5 · Cited by 102

3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury

Zhang, H., Ni, W., Yu, G., Geng, Y., Lou, J., Qi, J., Chen, Y., Li, F., Ye, H., Ma, H., et al. (2023) · Theranostics · doi:10.7150/thno.78370 · Cited by 101

Role of pyroptosis in the pathogenesis of various neurological diseases

Oladapo, A., Jackson, T., Menolascino, J., & Periyasamy, P. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.001 · Cited by 101

Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

Xin, T., & Lu, C. (2020) · Aging · doi:10.18632/aging.102899 · Cited by 99

Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage

Gu, L., Sun, M., Li, R., Zhang, X., Tao, Y., Yuan, Y., Xu, L., & Xie, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.810582 · Cited by 99

Curcumin Activates ROS Signaling to Promote Pyroptosis in Hepatocellular Carcinoma HepG2 Cells

Liang, W., Gong, Y.-X., Li, H., Sun, F., LI, W.-L., Chen, D., XIE, D.-P., Ren, C., Guo, X., Wang, Z., et al. (2021) · In Vivo · doi:10.21873/invivo.12253 · Cited by 97

Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury

Liu, B., He, R., Zhang, L., Hao, B., Jiang, W., Wang, W., & Geng, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.631256 · Cited by 97

Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway

Cai, M., Zhuang, W., Lv, E., Liu, Z., Wang, Y., Zhang, W., & Fu, W. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105221 · Cited by 97

Mechanisms of immune response and cell death in ischemic stroke and their regulation by natural compounds

Gong, Z., Guo, J., Liu, B., Guo, Y., Cheng, C., Jiang, Y., Liang, N., Hu, M., Song, T., Yang, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1287857 · Cited by 97

Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging

Barbu, E., Popescu, M.-R., Popescu, A.-C., & Balanescu, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020963 · Cited by 96

Plasma Membrane Pores Drive Inflammatory Cell Death

Kolbrink, B., Riebeling, T., Kunzendorf, U., & Krautwald, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00817 · Cited by 49

Cell death–mediated cytokine release and its therapeutic implications

Place, D. E., & Kanneganti, T. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181892 · Cited by 84

Overview of necroptosis and pyroptosis signaling pathways

Chen, L., Li, S., & Zhou, X. (2020) · Zhonghua weishengwuxue he mianyixue zazhi · doi:10.3760/cma.j.cn112309-20190605-00176

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

Boaru, D. L., Castro-Martinez, P. D., García-Montero, C., Fraile‐Μartinez, O., Alhaddadin, M. N. M., Barrena-Blázquez, S., López-González, L., Tasende, C., Hurtado, R. A., Giménez, T. R., et al. (2026) · MedComm · doi:10.1002/mco2.70844 · Cited by 2

What Is the Pathobiology of Inflammation to Cell Death? Apoptosis, Necrosis, Necroptosis, Autophagic Cell Death, Pyroptosis, and NETosis

Kang, R., & Tang, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-30079-5_5 · Cited by 6