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A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice
Open accessAbstract
In female mammals, up-regulation of Xist triggers X-chromosome inactivation in cis. Up-regulation is inhibited by sequences 3′ to Xist contained within the antisense locus, Tsix . Inhibition could depend on transcription of Tsix and/or on DNA elements therein. Here we test the role of Tsix transcription by augmenting the duration and strength of Tsix expression. We find that Tsix hypertranscription is sufficient to block Xist RNA accumulation in a cis-limited manner. We propose that Tsix transcription is necessary to restrict Xist activity on the future active X and, conversely, that Tsix repression is required for Xist RNA accumulation on the future inactive X. We also find that Tsix hypertranscription does not affect X-chromosome choice. Thus, choice is mediated by elements within Tsix that are independent of promoter activity.
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Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Cited by
Chromatin modification and epigenetic reprogramming in mammalian development
Li, E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg887 · Cited by 1,900
The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation
Tian, D., Sun, S., & Lee, J. T. (2010) · Cell · doi:10.1016/j.cell.2010.09.049 · Cited by 522
Self-citationX Chromosome Dosage Compensation: How Mammals Keep the Balance
Payer, B., & Lee, J. T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091711 · Cited by 521
Self-citationXist RNA and the Mechanism of X Chromosome Inactivation
Plath, K., Mlynarczyk-Evans, S., Nusinow, D. A., & Panning, B. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.042902.092433 · Cited by 450
From telomere to telomere: The transcriptional and epigenetic state of human repeat elements
Hoyt, S. J., Storer, J. M., Hartley, G. A., Grady, P. G. S., Gershman, A., de Lima, L. G., Limouse, C., Halabian, R., Wojenski, L., Rodriguez, M., et al. (2022) · Science · doi:10.1126/science.abk3112 · Cited by 411
Metadata
- Authors
- Stavropoulos, N., Lu, N., & Lee, J. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-07-31
- Volume
- 98
- Issue
- 18
- Pages
- 10232-10237
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2129578444
- Cited by
- 178
- References
- 1
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Stavropoulos, N., Lu, N., & Lee, J. T. (2001). A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.171243598
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