Cited by 393Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

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Definition of the hypothalamic GnRH pulse generator in mice

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Clarkson, Jenny, Han, Su Young, Piet, Richard, McLennan, Timothy, Kane, Grace M., Ng, Jamie, Porteous, Robert W., Kim, Joon S., Colledge, William H., Iremonger, Karl J., Herbison, Allan E.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1713897114PMC PMC5703322

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Abstract

Significance Neural networks located in the hypothalamus are responsible for generating ultradian patterns of hormone secretion that control a wide variety of functions. How these neural networks generate pulsatile hormone secretion remains unknown. We report here that a population of hypothalamic kisspeptin neurons represents the gonadotropin-releasing hormone (GnRH) pulse generator. These cells have the remarkable ability to generate synchronized GnRH secretion every 9 min to drive pulsatile gonadotropin hormone secretion in the blood. These observations indicate the arcuate kisspeptin neurons as the origin of reproductive hormone pulsatility in mice and offer the prospect of better understanding and manipulating fertility in the clinic.

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Authors: Clarkson, J., Han, S. Y., Piet, R., McLennan, T., Kane, G. M., Ng, J., Porteous, R. W., Kim, J. S., Colledge, W. H., Iremonger, K. J., & Herbison, A. E.
Affiliations: University of Otago (NZ)
University of Cambridge (GB)
Corresponding author: Herbison, Allan E.
ORCID: Clarkson, Jenny
Han, Su Young
Piet, Richard
McLennan, Timothy
Kim, Joon S.
Colledge, William H.
Iremonger, Karl J.
Herbison, Allan E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-11-06
Volume: 114
Issue: 47
Pages: E10216-E10223
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1713897114
PMC: PMC5703322
OpenAlex: W2767899680
Cited by: 392
References: 42
Citations by year: 2026: 28 · 2025: 33 · 2024: 51 · 2023: 52 · 2022: 55 · 2021: 51 · 2020: 39 · 2019: 48 · 2018: 33 · 2017: 2
FWCI: 38.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 181 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
Apollo
Funders: New Zealand Health Research Council (12-670, 16-148)
Royal Society of New Zealand (none)
RCUK | Biotechnology and Biological Sciences Research Council ((BB/K003178)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: kisspeptin neurons, gonadotropin-releasing hormone, GnRH pulse generator, hypothalamus, arcuate nucleus, pulsatile hormone secretion, ultradian rhythms, gonadotropin secretion, fertility
MeSH terms: Action Potentials, Animals, Arcuate Nucleus of Hypothalamus, Female, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Periodicity, Photometry, Mice, Voltage-Sensitive Dye Imaging, Kisspeptins, Optogenetics

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