The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Metabolic division of labor in microbial systems
Open accessAbstract
Significance: If contained in a single population a complex metabolic pathway can impose a burden on the host, decreasing the system’s overall productivity. This limitation can be overcome by division of labor (DOL), where distinct populations perform different steps of the pathway, thus reducing the burden on each population. By compartmentalizing reactions, however, DOL reduces their efficiency by introducing a transport barrier for metabolites and enzymes. It remains unclear how the trade-off between reducing burden and decreasing reaction efficiency dictates the potential benefit of DOL. Through the analysis of different metabolic pathways we derive a general criterion establishing when DOL outperforms a single population. Our results can guide rational engineering of metabolic pathways and provide insights into operation of natural pathways.
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High-level semi-synthetic production of the potent antimalarial artemisinin
Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature · doi:10.1038/nature12051 · Cited by 2,060
Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
Atsumi, S., Hanai, T., & Liao, J. C. (2008) · Nature · doi:10.1038/nature06450 · Cited by 1,945
Constraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods
Lewis, N. E., Nagarajan, H., & Palsson, B. O. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2737 · Cited by 779
Optimality and evolutionary tuning of the expression level of a protein
Dekel, E., & Alon, U. (2005) · Nature · doi:10.1038/nature03842 · Cited by 766
Growth Rate-Dependent Global Effects on Gene Expression in Bacteria
Klumpp, S., Zhang, Z., & Hwa, T. (2009) · Cell · doi:10.1016/j.cell.2009.12.001 · Cited by 703
Bacterial Adaptation through Loss of Function
Hottes, A. K., Freddolino, L., Khare, A., Donnell, Z. N., Liu, J. C., & Tavazoie, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003617 · Cited by 270
Cited by
Saleem, M., Hu, J., & Jousset, A. (2019) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-110617-062605 · Cited by 437
Engineered microbial consortia: strategies and applications
Duncker, K. E., Holmes, Z. A., & You, L. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01699-9 · Cited by 196
Self-citationBacteria-driven phthalic acid ester biodegradation: Current status and emerging opportunities
Hu, R., Zhao, H., Xu, X., Wang, Z., Yu, K., Shu, L., Yan, Q., Wu, B., Mo, C., He, Z., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106560 · Cited by 176
Liang, Y., Ma, A., & Zhuang, G. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.829717 · Cited by 146
Defining Division of Labor in Microbial Communities
Giri, S., Waschina, S., Kaleta, C., & Kost, C. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.06.023 · Cited by 89
Metadata
- Authors
- Tsoi, R., Wu, F., Zhang, C., Bewick, S., Karig, D., & You, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-02-20
- Volume
- 115
- Issue
- 10
- Pages
- 2526-2531
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2793358513
- Cited by
- 295
- References
- 6
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- green
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