Probiotic mixture containing lactobacillus helveticus, bifidobacterium longum and lactiplantibacillus plantarum affects brain responses to an arithmetic stress task in healthy subjects: a randomised clinical trial and proof-of-Concept study
Open accessAbstract
Probiotics are suggested to impact physiological and psychological stress responses by acting on the gut-brain axis. We investigated if a probiotic product containing Bifidobacterium longum R0175, Lactobacillus helveticus R0052 and Lactiplantibacillus plantarum R1012 affected stress processing in a double-blinded, randomised, placebo-controlled, crossover proof-of-concept study (NCT03615651). Twenty-two healthy subjects (24.2 ± 3.4 years, 6 men/16 women) underwent a probiotic and placebo intervention for 4 weeks each, separated by a 4-week washout period. Subjects were examined by functional magnetic resonance imaging while performing the Montreal Imaging Stress Task (MIST) as well as an autonomic nervous system function assessment during the Stroop task. Reduced activation in regions of the lateral orbital and ventral cingulate gyri was observed after probiotic intervention compared to placebo. Significantly increased functional connectivity was found between the upper limbic region and medioventral area. Interestingly, probiotic intervention seemed to predominantly affect the initial stress response. Salivary cortisol secretion during the task was not altered. Probiotic intervention did not affect cognitive performance and autonomic nervous system function during Stroop. The probiotic intervention was able to subtly alter brain activity and functional connectivity in regions known to regulate emotion and stress responses. These findings support the potential of probiotics as a non-pharmaceutical treatment modality for stress-related disorders.
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Rosell®-52 and Rosell®-175 interventions were able to alter functional connectivity in brain regions that are active and regulate emotional and stress responses.
“This suggests that the Rosell®-52 and Rosell®-175 interventions were able to alter functional connectivity in regions of the brain that are active and regulate emotional and stress responses.”
From Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial (2023) · cites this paper as [27]
The Abstract reports that the probiotic intervention altered functional connectivity in regions known to regulate emotion and stress responses. But the Study Intervention section describes one product containing R0052 and R0175 alongside a third strain, R1012; it does not establish an effect of the two named strains separately. (LLM, conf=0.87)
Experimental — accuracy not yet measuredIn a clinical study, after four weeks of Rosell®-52 and Rosell®-175 probiotic consumption, functional magnetic resonance imaging registered a reduction in activation of the lateral orbital and ventral cingulate regions and a significant increase in functional connectivity between the superior limbic and mid-ventral regions compared with placebo.
“In clinical study which examined the efficacy of Rosell®-52 and Rosell®-175 (3×109 CFU of probiotics daily), after four weeks of probiotic consumption, functional magnetic resonant imaging registered a reduction in the activation of the lateral orbital and ventral cingulate regions and a significant increase in functional connectivity between the superior limbic and mid-ventral regions were”
From Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial (2023) · cites this paper as [27]
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Experimental — accuracy not yet measuredStudies have identified compositional and functional changes in the intestine and brain, along with distinct changes in brain morphology, resting-state brain function, brain activity, and functional connectivity in regions known to regulate stress.
“These studies have identified compositional and functional changes in the intestine and brain, along with distinct changes in brain morphology, resting-state brain function, brain activity and functional connectivity in regions known to regulate stress (472, 473).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [473]
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- Authors
- Edebol Carlman, H. M. T., Rode, J., König, J., Repsilber, D., Hutchinson, A. N., Thunberg, P., Persson, J., Kiselev, A., Pruessner, J. C., & Brummer, R. J.
- Affiliations
- Nutrition-Gut-Brain Interactions Research Centre, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, 70182 Örebro, Sweden
- Örebro University (SE)
- University of Konstanz (DE)
- Corresponding author
- Rode, Julia
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-03-22
- Volume
- 14
- Issue
- 7
- Pages
- 1329
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9002567
- OpenAlex
- W4223543456
- Cited by
- 37
- References
- 40
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 4
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion, cc-by)
- Funders
- Swedish Knowledge Foundation (20150081)
- Global Medical Innovation, Pfizer Consumer Healthcare (2018)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, Lactobacillus helveticus, Bifidobacterium longum, Lactobacillus plantarum, gut-brain axis, psychological stress, Montreal Imaging Stress Task, functional connectivity, salivary cortisol, autonomic nervous system, Stroop task, cognitive performance, stress-related disorders
- MeSH terms
- Bifidobacterium longum, Brain, Double-Blind Method, Female, Humans, Male, Probiotics, Lactobacillus helveticus, Healthy Volunteers
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