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Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome
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Significance: Night shift work is associated with adverse health effects, including diabetes, cardiovascular disease, and cancer. Understanding the molecular mechanisms that underlie this association is instrumental in advancing the diagnosis, prevention, and treatment of shift work-related health concerns. We characterized the effect on genome-wide gene expression levels of a 4-day protocol simulating night shifts in healthy human subjects under highly controlled laboratory conditions. We demonstrate that this night shift protocol leads to a dampening of gene expression rhythms and a desynchrony between rhythmic transcripts and the shifted sleep/wake cycle. Moreover, we uncovered key biological processes and regulatory molecules that are altered during this night shift protocol and that may contribute to the development of health problems on the long term.
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“A recent study could link night shift work with a loss in temporal coordination between the human circadian transcriptome and its environment, most notably by affecting the natural killer cell‐mediated immune response and Jun/AP1 and STAT pathways 98.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [98]
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Moretti, C., Cisterna, F., & Pérez, F. (2021) · Revista Chilena de Salud Pública · doi:10.5354/0719-5281.2021.65201 · Cited by 5
Kervezee, L., Koshy, A., Cermakian, N., & Boivin, D. B. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221132088 · Cited by 4
Self-citationBrain structural correlates of subjective sleepiness and insomnia symptoms in shift workers
Jeong, H., Yeo, H., Lee, K. H., Kim, N., Shin, J., Seo, M. C., Jeon, S., Lee, Y. J., & Kim, S. J. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1330695 · Cited by 4
Cabral, P. C., Weinerman, J., Olivier, M., & Cermakian, N. (2024) · iScience · doi:10.1016/j.isci.2024.109684 · Cited by 6
Self-citationKoritala, B. S. C., Dakup, P., Porter, K. I., & Gaddameedhi, S. (2023) · F1000Research · doi:10.12688/f1000research.136998.2 · Cited by 4
Boivin, D. B., & Boudreau, P. (2023) · Sleep Health · doi:10.1016/j.sleh.2023.09.005 · Cited by 4
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Metadata
- Authors
- Kervezee, L., Cuesta, M., Cermakian, N., & Boivin, D. B.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-05-07
- Volume
- 115
- Issue
- 21
- Pages
- 5540-5545
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6003514
- OpenAlex
- W2802571577
- Cited by
- 136
- References
- 37
- Citations by year
- 2026: 14 · 2025: 12 · 2024: 24 · 2023: 15 · 2022: 16 · 2021: 22 · 2020: 7 · 2019: 18 · 2018: 8
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Gouvernement du Canada | Canadian Institutes of Health Research (MOP-102724)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- night shift work, circadian misalignment, circadian rhythm, peripheral blood mononuclear cells, transcriptome, rhythmic gene expression, natural killer cells, immune response, STAT pathway
- MeSH terms
- Shift Work Schedule, Adolescent, Adult, Circadian Rhythm, Computer Simulation, Female, Humans, Leukocytes, Mononuclear, Male, Sleep, Sleep Disorders, Circadian Rhythm, Young Adult, Transcriptome
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