Cited by 678Circadian rhythm and melatoninCancer-related Molecular PathwaysSleep and Work-Related Fatigue

The circadian clock: pacemaker and tumour suppressor

Fu, Loning, Lee, Cheng Chi·2003·Nature reviews. Cancer

Abstract

The circadian rhythms are daily oscillations in various biological processes that are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer in humans. One of the cellular processes that is regulated by circadian rhythm is cell proliferation, which often shows asynchrony between normal and malignant tissues. This asynchrony highlights the importance of the circadian clock in tumour suppression in vivo and is one of the theoretical foundations for cancer chronotherapy. Investigation of the mechanisms by which the circadian clock controls cell proliferation and other cellular functions might lead to new therapeutic targets.

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Crossref · 10.1038/nrc1072

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  • The circadian system and its prime marker, melatonin, are considered to have antitumor effects through multiple pathways, including antioxidant activity, anti-inflammatory effects, and immune enhancement.

    “The circadian system and its prime marker, melatonin, are considered to have antitumor effects through multiple pathways, including antioxidant activity, anti-inflammatory effects, and immune enhancement.33-37”

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Authors
Fu, L., & Lee, C. C.
Affiliations
Baylor College of Medicine (US)
Corresponding author
Lee, Cheng Chi
Venue
Nature reviews. Cancer
Published
2003-05-01
Volume
3
Issue
5
Pages
350-361
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W1997364930
Cited by
678
References
200
Citations by year
2026: 7 · 2025: 14 · 2024: 16 · 2023: 25 · 2022: 25 · 2021: 21 · 2020: 26 · 2019: 33 · 2018: 42 · 2017: 36 · 2016: 29 · 2015: 37 · 2014: 34 · 2013: 44 · 2012: 42
FWCI
3.06
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian clock, circadian rhythm, tumor suppression, cell proliferation, cancer chronotherapy, circadian rhythm disruption, cancer, therapeutic target
MeSH terms
Animals, Biological Clocks, Circadian Rhythm, Eye Proteins, Humans, Neoplasms, Suprachiasmatic Nucleus, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-myc

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