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Cited by 333Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

Circadian disruption: what do we actually mean?

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Vetter, Céline·2020·European Journal of Neuroscience
DOI 10.1111/ejn.14255PMC PMC6504624
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Abstract

The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re‐synchronization to local environmental time cues, but this re‐synchronization is oftentimes accompanied by adverse short‐term consequences. When such challenges are experienced chronically, adaptation may not be achieved, as for example in the case of rotating night shift workers. The transient and chronic disturbance of the circadian system is most frequently referred to as “circadian disruption”, but many other terms have been proposed and used to refer to similar situations. It is now beyond doubt that the circadian system contributes to health and disease, emphasizing the need for clear terminology when describing challenges to the circadian system and their consequences. The goal of this review is to provide an overview of the terms used to describe disruption of the circadian system, discuss proposed quantifications of disruption in experimental and observational settings with a focus on human research, and highlight limitations and challenges of currently available tools. For circadian research to advance as a translational science, clear, operationalizable, and scalable quantifications of circadian disruption are key, as they will enable improved assessment and reproducibility of results, ideally ranging from mechanistic settings, including animal research, to large‐scale randomized clinical trials.

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  • Behaviors misaligned with the central clock may contribute to chronodisruption, as observed in night shift workers and, to a lesser extent, in natural late-night eaters.

    “Behaviors misaligned with the central clock may contribute to chronodisruption, as observed in night shift workers and, to a lesser extent, in natural late-night eaters (4).”

    From Interplay of Dinner Timing and <i>MTNR1B</i> Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [4]

    The Observational, Field, and Ecological Studies section describes night shift work as a common proxy for circadian disruption and links it to nighttime eating and activity. The paper also defines behavioral misalignment as feeding or sleep cycles misaligned with the central clock. It does not establish that natural late-night eaters experience chronodisruption, or that they do so to a lesser extent than night shift workers; page numbers were not provided in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Vetter, C.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Vetter, Céline
ORCID
Vetter, Céline
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2018-12-05
Volume
51
Issue
1
Pages
531-550
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/ejn.14255
PMC
PMC6504624
OpenAlex
W2900001604
Cited by
333
References
29
Citations by year
2026: 41 · 2025: 65 · 2024: 43 · 2023: 40 · 2022: 49 · 2021: 42 · 2020: 43 · 2019: 10
FWCI
3.32
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R01 DK105072, 5R21OH011052)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian rhythm disruption, circadian system, circadian rhythm, jet lag, shift work, rotating night shifts, circadian misalignment, terminology, chronobiology, health and disease
MeSH terms
Animals, Circadian Rhythm, Humans, Reproducibility of Results

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