The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome
Open accessAbstract
Significance: Night shift work is associated with adverse health effects, including diabetes, cardiovascular disease, and cancer. Understanding the molecular mechanisms that underlie this association is instrumental in advancing the diagnosis, prevention, and treatment of shift work-related health concerns. We characterized the effect on genome-wide gene expression levels of a 4-day protocol simulating night shifts in healthy human subjects under highly controlled laboratory conditions. We demonstrate that this night shift protocol leads to a dampening of gene expression rhythms and a desynchrony between rhythmic transcripts and the shifted sleep/wake cycle. Moreover, we uncovered key biological processes and regulatory molecules that are altered during this night shift protocol and that may contribute to the development of health problems on the long term.
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“A recent study could link night shift work with a loss in temporal coordination between the human circadian transcriptome and its environment, most notably by affecting the natural killer cell‐mediated immune response and Jun/AP1 and STAT pathways 98.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [98]
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Citations
Cites
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,786
Health consequences of shift work and insufficient sleep
Kecklund, G., & Axelsson, J. (2016) · BMJ · doi:10.1136/bmj.i5210 · Cited by 1,195
Cornélissen, G. (2014) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-11-16 · Cited by 822
Detecting Rhythms in Time Series with RAIN
Thaben, P. F., & Westermark, P. O. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414553029 · Cited by 709
The circadian clock: pacemaker and tumour suppressor
Fu, L., & Lee, C. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1072 · Cited by 678
Impacts of shift work on sleep and circadian rhythms
Boivin, D. B., & Boudreau, P. (2014) · Pathologie Biologie · doi:10.1016/j.patbio.2014.08.001 · Cited by 639
Self-citationNatural killer cell memory in infection, inflammation and cancer
Cerwenka, A., & Lanier, L. L. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2015.9 · Cited by 593
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576
MetaCycle: an integrated R package to evaluate periodicity in large scale data
Wu, G., Anafi, R. C., Hughes, M. E., Kornacker, K., & Hogenesch, J. B. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw405 · Cited by 560
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The Global Problem of Insufficient Sleep and Its Serious Public Health Implications
Chattu, V. K., Manzar, M. D., Kumary, S., Burman, D., Spence, D. W., & Pandi-Perumal, S. R. (2018) · Healthcare · doi:10.3390/healthcare7010001 · Cited by 1,028
The role of insufficient sleep and circadian misalignment in obesity
Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 733
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 580
Self-citationCircadian disruption: what do we actually mean?
Vetter, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14255 · Cited by 333
Navigating Challenges and Opportunities in Multi-Omics Integration for Personalized Healthcare
Mohr, A. E., Ortega-Santos, C. P., Whisner, C. M., Klein-Seetharaman, J., & Jasbi, P. (2024) · Biomedicines · doi:10.3390/biomedicines12071496 · Cited by 311
Metadata
- Authors
- Kervezee, L., Cuesta, M., Cermakian, N., & Boivin, D. B.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-05-07
- Volume
- 115
- Issue
- 21
- Pages
- 5540-5545
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6003514
- OpenAlex
- W2802571577
- Cited by
- 136
- References
- 37
- Citations by year
- 2026: 14 · 2025: 12 · 2024: 24 · 2023: 15 · 2022: 16 · 2021: 22 · 2020: 7 · 2019: 18 · 2018: 8
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Gouvernement du Canada | Canadian Institutes of Health Research (MOP-102724)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- night shift work, circadian misalignment, circadian rhythm, peripheral blood mononuclear cells, transcriptome, rhythmic gene expression, natural killer cells, immune response, STAT pathway
- MeSH terms
- Shift Work Schedule, Adolescent, Adult, Circadian Rhythm, Computer Simulation, Female, Humans, Leukocytes, Mononuclear, Male, Sleep, Sleep Disorders, Circadian Rhythm, Young Adult, Transcriptome
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