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Cited by 280

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Nuclear import of hepatitis B virus capsids and release of the viral genome

Open access
Rabe, Birgit, Vlachou, Angelika, Panté, Nelly, Helenius, Ari, Kann, Michael·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1730940100
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Abstract

While studying the import of the hepatitis B virus genome into the nucleus of permeabilized tissue culture cells, we found that viral capsids were imported in intact form through the nuclear pore into the nuclear basket. Import depended on phosphorylation of the capsid protein and was mediated by the cellular transport receptors importin α and β. Virus-derived capsids that contained the mature viral genome were able to release the viral DNA and capsid protein into the nucleoplasm. The uncoating reaction was independent of Ran, a GTP-binding enzyme responsible for dissociating other imported cargoes from the inner face of the nuclear pore. Immature capsids that did not contain the mature viral genome reached the basket but did not release capsid proteins nor immature genomes into the nucleoplasm. The different fate of mature and immature capsids after passing the nuclear pore indicates that the outcome of a nuclear import event may be regulated within the nuclear basket.

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Metadata

Authors
Rabe, B., Vlachou, A., Panté, N., Helenius, A., & Kann, M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2003-08-08
Volume
100
Issue
17
Pages
9849-9854
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1730940100
OpenAlex
W1979009813
Cited by
280
References
26
FWCI
4.07
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Nuclear import of hepatitis B virus capsids and release of the viral genome. https://app.cochat.ai/papers/10.1073/pnas.1730940100
The paper
Rabe, B., Vlachou, A., Panté, N., Helenius, A., & Kann, M. (2003). Nuclear import of hepatitis B virus capsids and release of the viral genome. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1730940100

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.