The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Pharmacological bypass of NAD + salvage pathway protects neurons from chemotherapy-induced degeneration
Open accessAbstract
Significance: Axon degeneration is caused by multiple chemotherapeutic agents and is a hallmark of chemotherapy-induced peripheral neuropathy (CIPN). CIPN is associated with the loss of the essential metabolite nicotinamide adenine dinucleotide (NAD + ), a vital metabolite involved in energy homeostasis, but whether NAD + loss or the accumulation of an NAD + precursor, nicotinamide mononucleotide (NMN), is responsible for axon degeneration is controversial. We found that axon degeneration caused by vincristine, a widely used chemotherapeutic agent, could be ameliorated by forcing peripheral neurons to use an NAD + biosynthetic pathway that bypasses NMN formation. This strategy provides an approach for preventing CIPN.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“NMN may exacerbate axon degeneration in vitro induced by the chemotherapeutic agent vincristine”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Liu et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
Bieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750
Self-citationChemotherapy‐induced peripheral neurotoxicity: A critical analysis
Park, S. B., Goldstein, D., Krishnan, A. V., Lin, C. S.-Y., Friedlander, M. L., Cassidy, J., Koltzenburg, M., & Kiernan, M. C. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21204 · Cited by 745
dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Osterloh, J. M., Yang, J. H., Rooney, T. M., Fox, A. N., Adalbert, R., Powell, E. H., Sheehan, A. E., Avery, M. A., Hackett, R., Logan, M. A., et al. (2012) · Science · doi:10.1126/science.1223899 · Cited by 688
Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve
Lunn, E. R., Perry, V. H., Brown, M. C., Rosen, H., & Gordon, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00771.x · Cited by 646
Wallerian degeneration: an emerging axon death pathway linking injury and disease
Conforti, L., Gilley, J., & Coleman, M. P. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3680 · Cited by 630
Essuman, K., Summers, D. W., Sasaki, Y., Mao, X., DiAntonio, A., & Milbrandt, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.022 · Cited by 619
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene
Mack, T. G. A., Reiner, M., Beirowski, B., Mi, W., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., et al. (2001) · Nature Neuroscience · doi:10.1038/nn770 · Cited by 611
SARM1 activation triggers axon degeneration locally via NAD + destruction
Gerdts, J., Brace, E. J., Sasaki, Y., DiAntonio, A., & Milbrandt, J. (2015) · Science · doi:10.1126/science.1258366 · Cited by 593
REVERSIBLE ENZYMATIC SYNTHESIS OF DIPHOSPHOPYRIDINE NUCLEOTIDE AND INORGANIC PYROPHOSPHATE
Kornberg, A. (1950) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56513-3 · Cited by 503
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–105 of 105
Yang, T., Wang, Y., Liao, W., Zhang, S., Wang, S., Xu, N., Xie, W., Luo, C., Wang, Y., Wang, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986592
Yang, T., Wang, Y., Liao, W., Zhang, S., Wang, S., Xu, N., Xie, W., Luo, C., Wang, Y., Wang, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986589
Yang, T., Wang, Y., Liao, W., Zhang, S., Wang, S., Xu, N., 谢伟东, Luo, C., Wang, Y., Wang, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986586
Yang, T., Wang, Y., Liao, W., Zhang, S., Wang, S., Xu, N., Xie, W., Luo, C., Wang, Y., Wang, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986583
Asimakopoulos, T., Kokkinou, E., Faze, T., Labuz, A., Pearce, E. L., Koliatsos, V. E., & Alexandris, A. S. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116047
Metadata
- Authors
- Liu, H.-W., Smith, C. B., Schmidt, M. S., Cambronne, X. A., Cohen, M. S., Migaud, M. E., Brenner, C., & Goodman, R. H.
- Affiliations
- Oregon Health & Science University (US)
- University of Iowa (US)
- University of South Alabama (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-09-26
- Volume
- 115
- Issue
- 42
- Pages
- 10654-10659
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6196523
- OpenAlex
- W2894340007
- Cited by
- 105
- References
- 29
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 16 · 2021: 23 · 2020: 23 · 2019: 15
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | National Institutes of Health (1R01AG055431-01, DP2GM126897)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- chemotherapy-induced peripheral neuropathy, NAD+ salvage pathway, nicotinamide mononucleotide, NAD biosynthesis, axonal degeneration, vincristine, peripheral neurons, neuroprotection
- MeSH terms
- Acrylamides, Animals, Antineoplastic Agents, Phytogenic, Drug Combinations, Francisella tularensis, Ganglia, Spinal, NAD, Nerve Degeneration, Neurons, Niacinamide, Nicotinamide Mononucleotide, Piperidines, Pyridinium Compounds, Vincristine, Nicotinamide Phosphoribosyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
