Brenner, Charles

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Bieganowski, P., & Brenner, C. (2004) · Cell

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 750

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD + Precursor Vitamins in Human Nutrition

Bogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 707

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 697

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., et al. (2019) · Cell Reports

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 448

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., et al. (2020) · Nature Metabolism

Sirtuins and Resveratrol in MedicineTelomeres, Telomerase, and Senescence

Cited by 420

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

Belenky, P., Racette, F. G., Bogan, K. L., McClure, J. M., Smith, J. S., & Brenner, C. (2007) · Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 411

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Ratajczak, J., Joffraud, M., Trammell, S. A. J., Ras, R., Canela, N., Boutant, M., Kulkarni, S. S., Rodrigues, M., Redpath, P., Migaud, M. E., et al. (2016) · Nature Communications

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 378

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

Diguet, N., Trammell, S. A. J., Tannous, C., Deloux, R., Piquereau, J., Mougenot, N., Gouge, A., Gressette, M., Manoury, B., Blanc, J., et al. (2018) · Circulation

Sirtuins and Resveratrol in MedicineCardiomyopathy and Myosin Studies

Cited by 358

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

Mitchell, S. J., Bernier, M., Aon, M. A., Cortassa, S., Kim, E. Y., Fang, E. F., Palacios, H. H., Ali, A., Navas-Enamorado, I., Di Francesco, A., et al. (2018) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 338

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

Trammell, S. A. J., Weidemann, B. J., Chadda, A., Yorek, M. S., Holmes, A., Coppey, L. J., Obrosov, A., Kardon, R. H., Yorek, M. A., & Brenner, C. (2016) · Scientific Reports

Sirtuins and Resveratrol in MedicineNatural Antidiabetic Agents Studies

Cited by 301

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

Dollerup, O. L., Christensen, B., Svart, M., Schmidt, M. S., Sulek, K., Ringgaard, S., Stødkilde-Jørgensen, H., Møller, N., Brenner, C., Treebak, J. T., et al. (2018) · The American Journal of Clinical Nutrition

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 282

Microbial NAD Metabolism: Lessons from Comparative Genomics

Gazzaniga, F., Stebbins, R., Chang, S. Z., McPeek, M. A., & Brenner, C. (2009) · Microbiology and Molecular Biology Reviews

Biochemical and Molecular ResearchSirtuins and Resveratrol in Medicine

Cited by 230

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

Conze, D., Brenner, C., & Kruger, C. L. (2019) · Scientific Reports

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 210

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Heer, C. D., Sanderson, D. J., Voth, L. S., Alhammad, Y. M. O., Schmidt, M. S., Trammell, S. A. J., Perlman, S., Cohen, M. S., Fehr, A. R., & Brenner, C. (2020) · Journal of Biological Chemistry

Sirtuins and Resveratrol in Medicineinterferon and immune responses

Cited by 192

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk

Trammell, S. A., Yu, L., Redpath, P., Migaud, M. E., & Brenner, C. (2016) · The Journal of Nutrition

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 112

Pharmacological bypass of NAD + salvage pathway protects neurons from chemotherapy-induced degeneration

Liu, H.-W., Smith, C. B., Schmidt, M. S., Cambronne, X. A., Cohen, M. S., Migaud, M. E., Brenner, C., & Goodman, R. H. (2018) · Proceedings of the National Academy of Sciences

Cancer Treatment and PharmacologySirtuins and Resveratrol in Medicine

Cited by 105

Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals

Belenky, P., Christensen, K. C., Gazzaniga, F., Pletnev, A. A., & Brenner, C. (2009) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 95

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

Evans, C., Bogan, K. L., Song, P., Burant, C. F., Kennedy, R. T., & Brenner, C. (2010) · BMC Chemical Biology

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Saccharomyces cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter Nrt1

Belenky, P. A., Moga, T. G., & Brenner, C. (2008) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineFungal and yeast genetics research

Cited by 78

Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring

Ear, P. H., Chadda, A., Gumusoglu, S. B., Schmidt, M. S., Vogeler, S., Malicoat, J., Kadel, J., Moore, M. M., Migaud, M. E., Stevens, H. E., et al. (2019) · Cell Reports

Sirtuins and Resveratrol in MedicineBirth, Development, and Health

Cited by 72

Identification of Isn1 and Sdt1 as Glucose- and Vitamin-regulated Nicotinamide Mononucleotide and Nicotinic Acid Mononucleotide 5′-Nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside

Bogan, K. L., Evans, C., Belenky, P., Song, P., Burant, C. F., Kennedy, R., & Brenner, C. (2009) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 63

Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease

Feng, S., Liu, Y., Zhou, Y., Shu, Z., Cheng, Z., Brenner, C., & Feng, P. (2023) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsHerpesvirus Infections and Treatments

Cited by 36

Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model

Takaso, Y., Noda, M., Hattori, T., Roboon, J., Hatano, M., Sugimoto, H., Brenner, C., Yamamoto, Y., Okamoto, H., Higashida, H., et al. (2020) · Scientific Reports

Nerve injury and regenerationFacial Nerve Paralysis Treatment and Research

Cited by 17